ICD-10-CM Excludes1 Notes · Chapter 4 · FY 2027 E00-E89

Excludes1 Notes in Chapter 4: Endocrine, nutritional and metabolic diseases ICD-10-CM

An Excludes1 note means "NOT CODED HERE": the excluded code should never be reported together with the code above the note. In Chapter 4 (E00-E89), notes printed in the chapter name other codes 295 times, and Excludes1 Notes anywhere in the Tabular List name the chapter’s codes 322 times, covering 177 distinct codes, categories and ranges. Switch views to read the list either way.

✓ From the official FY 2027 ICD-10-CM Tabular ListDefinitions follow the Official Guidelines, Section I.A

295

References in Its Notes

322

References to Its Codes

177

Chapter Codes Named

E00-E89

Chapter 4

Excludes1 Notes by the code that carries the note

119 of 119 shown

Chapter note Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
- transitory endocrine and metabolic disorders specific to newborn (P70-P74)
E00 Congenital iodine-deficiency syndrome applies to 4 codes
- subclinical iodine-deficiency hypothyroidism (E02)
E01 Iodine-deficiency related thyroid disorders and allied conditions applies to 4 codes
- congenital iodine-deficiency syndrome (E00.-)
- subclinical iodine-deficiency hypothyroidism (E02)
E03 Other hypothyroidism applies to 8 codes
- iodine-deficiency related hypothyroidism (E00-E02)
- postprocedural hypothyroidism (E89.0)
E03.0 Congenital hypothyroidism with diffuse goiter
- transitory congenital goiter with normal function (P72.0)
E03.4 Atrophy of thyroid (acquired)
- congenital atrophy of thyroid (E03.1)
E04 Other nontoxic goiter applies to 5 codes
- congenital goiter (NOS) (diffuse) (parenchymatous) (E03.0)
- iodine-deficiency related goiter (E00-E02)
E05 Thyrotoxicosis [hyperthyroidism] applies to 14 codes
- chronic thyroiditis with transient thyrotoxicosis (E06.2)
- neonatal thyrotoxicosis (P72.1)
E06 Thyroiditis applies to 7 codes
- postpartum thyroiditis (O90.5)
E06.1 Subacute thyroiditis
- autoimmune thyroiditis (E06.3)
E06.2 Chronic thyroiditis with transient thyrotoxicosis
- autoimmune thyroiditis (E06.3)
E07.1 Dyshormogenetic goiter
- transitory congenital goiter with normal function (P72.0)
E08 Diabetes mellitus due to underlying condition applies to 86 codes
- drug or chemical induced diabetes mellitus (E09.-)
- gestational diabetes (O24.4-)
- neonatal diabetes mellitus (P70.2)
- postpancreatectomy diabetes mellitus (E13.-)
- postprocedural diabetes mellitus (E13.-)
- secondary diabetes mellitus NEC (E13.-)
- type 1 diabetes mellitus (E10.-)
- type 2 diabetes mellitus (E11.-)
E09 Drug or chemical induced diabetes mellitus applies to 86 codes
- diabetes mellitus due to underlying condition (E08.-)
- gestational diabetes (O24.4-)
- neonatal diabetes mellitus (P70.2)
- postpancreatectomy diabetes mellitus (E13.-)
- postprocedural diabetes mellitus (E13.-)
- secondary diabetes mellitus NEC (E13.-)
- type 1 diabetes mellitus (E10.-)
- type 2 diabetes mellitus (E11.-)
E10 Type 1 diabetes mellitus applies to 87 codes
- diabetes mellitus due to underlying condition (E08.-)
- drug or chemical induced diabetes mellitus (E09.-)
- gestational diabetes (O24.4-)
- hyperglycemia NOS (R73.9)
- neonatal diabetes mellitus (P70.2)
- postpancreatectomy diabetes mellitus (E13.-)
- postprocedural diabetes mellitus (E13.-)
- secondary diabetes mellitus NEC (E13.-)
- type 2 diabetes mellitus (E11.-)
E11 Type 2 diabetes mellitus applies to 87 codes
- diabetes mellitus due to underlying condition (E08.-)
- drug or chemical induced diabetes mellitus (E09.-)
- gestational diabetes (O24.4-)
- neonatal diabetes mellitus (P70.2)
- postpancreatectomy diabetes mellitus (E13.-)
- postprocedural diabetes mellitus (E13.-)
- secondary diabetes mellitus NEC (E13.-)
- type 1 diabetes mellitus (E10.-)
E11.9 Type 2 diabetes mellitus without complications
- type 2 diabetes mellitus, without complications in remission (E11.A)
E11.A Type 2 diabetes mellitus without complications in remission
- type 2 diabetes mellitus, with complications (E11.0-E11.8)
- type 2 diabetes mellitus, without complications not in remission (E11.9)
E13 Other specified diabetes mellitus applies to 86 codes
- diabetes (mellitus) due to autoimmune process (E10.-)
- diabetes (mellitus) due to immune mediated pancreatic islet beta-cell destruction (E10.-)
- diabetes mellitus due to underlying condition (E08.-)
- drug or chemical induced diabetes mellitus (E09.-)
- gestational diabetes (O24.4-)
- neonatal diabetes mellitus (P70.2)
- type 1 diabetes mellitus (E10.-)
E16.0 Drug-induced hypoglycemia without coma
- diabetes with hypoglycemia without coma (E09.649)
E16.1 Other hypoglycemia
- diabetes with hypoglycemia (E08.649, E10.649, E11.649, E13.649)
- hypoglycemia in infant of diabetic mother (P70.1)
- neonatal hypoglycemia (P70.4)
E16.2 Hypoglycemia, unspecified
- diabetes with hypoglycemia (E08.649, E10.649, E11.649, E13.649)
Block note Block E20-E35 Disorders of other endocrine glands applies to 99 codes
- galactorrhea (N64.3)
- gynecomastia (N62)
E20 Hypoparathyroidism applies to 9 codes
- Di George's syndrome (D82.1)
- postprocedural hypoparathyroidism (E89.2)
- tetany NOS (R29.0)
- transitory neonatal hypoparathyroidism (P71.4)
E21 Hyperparathyroidism and other disorders of parathyroid gland applies to 6 codes
- adult osteomalacia (M83.-)
- ectopic hyperparathyroidism (E34.2)
- hungry bone syndrome (E83.81)
- infantile and juvenile osteomalacia (E55.0)
E21.1 Secondary hyperparathyroidism, not elsewhere classified
- secondary hyperparathyroidism of renal origin (N25.81)
E22 Hyperfunction of pituitary gland applies to 5 codes
- Cushing's syndrome (E24.-)
- Nelson's syndrome (E24.1)
- overproduction of ACTH not associated with Cushing's disease (E27.0)
- overproduction of pituitary ACTH (E24.0)
- overproduction of thyroid-stimulating hormone (E05.8-)
E22.0 Acromegaly and pituitary gigantism
- constitutional gigantism (E34.4)
- constitutional tall stature (E34.4)
- increased secretion from endocrine pancreas of growth hormone-releasing hormone (E16.8)
E23 Hypofunction and other disorders of the pituitary gland applies to 6 codes
- postprocedural hypopituitarism (E89.3)
- short stature due to endocrine disorder (E34.3-)
E23.2 Diabetes insipidus
- nephrogenic diabetes insipidus (N25.1)
E23.3 Hypothalamic dysfunction, not elsewhere classified
- Prader-Willi syndrome (Q87.11)
- Russell-Silver syndrome (Q87.19)
E24 Cushing's syndrome applies to 7 codes
- congenital adrenal hyperplasia (E25.0)
E25 Adrenogenital disorders applies to 3 codes
- indeterminate sex and pseudohermaphroditism (Q56)
- chromosomal abnormalities (Q90-Q99)
E27.0 Other adrenocortical overactivity
- Cushing's syndrome (E24.-)
E27.1 Primary adrenocortical insufficiency
- Addison only phenotype adrenoleukodystrophy (E71.528)
- amyloidosis (E85.-)
- tuberculous Addison's disease (A18.7)
- Waterhouse-Friderichsen syndrome (A39.1)
E27.4 Other and unspecified adrenocortical insufficiency applies to 2 codes
- adrenoleukodystrophy [Addison-Schilder] (E71.528)
- Waterhouse-Friderichsen syndrome (A39.1)
E28 Ovarian dysfunction applies to 8 codes
- isolated gonadotropin deficiency (E23.0)
- postprocedural ovarian failure (E89.4-)
E28.3 Primary ovarian failure applies to 3 codes
- pure gonadal dysgenesis (Q99.1)
- Turner's syndrome (Q96.-)
E28.8 Other ovarian dysfunction
- postprocedural ovarian failure (E89.4-)
E29 Testicular dysfunction applies to 4 codes
- androgen insensitivity syndrome (E34.5-)
- azoospermia or oligospermia NOS (N46.0-N46.1)
- isolated gonadotropin deficiency (E23.0)
- Klinefelter's syndrome (Q98.0-Q98.1, Q98.4)
E29.1 Testicular hypofunction
- postprocedural testicular hypofunction (E89.5)
E30.1 Precocious puberty
- Albright (-McCune) (-Sternberg) syndrome (Q78.1)
- central precocious puberty (E22.8)
- congenital adrenal hyperplasia (E25.0)
- female heterosexual precocious pseudopuberty (E25.-)
- male isosexual precocious pseudopuberty (E25.-)
E31 Polyglandular dysfunction applies to 8 codes
- ataxia telangiectasia [Louis-Bar] (G11.3)
- dystrophia myotonica [Steinert] (G71.11)
- pseudohypoparathyroidism (E20.1)
E31.1 Polyglandular hyperfunction
- multiple endocrine adenomatosis (E31.2-)
- multiple endocrine neoplasia (E31.2-)
E32 Diseases of thymus applies to 4 codes
- aplasia or hypoplasia of thymus with immunodeficiency (D82.1)
- myasthenia gravis (G70.0)
E32.8 Other diseases of thymus
- aplasia or hypoplasia with immunodeficiency (D82.1)
- thymoma (D15.0)
E34 Other endocrine disorders applies to 18 codes
- pseudohypoparathyroidism (E20.1)
E34.2 Ectopic hormone secretion, not elsewhere classified
- ectopic ACTH syndrome (E24.3)
E34.3 Short stature due to endocrine disorder applies to 7 codes
- achondroplastic short stature (Q77.4)
- hypochondroplastic short stature (Q77.4)
- nutritional short stature (E45)
- pituitary short stature (E23.0)
- progeria (E34.8)
- renal short stature (N25.0)
- Russell-Silver syndrome (Q87.19)
- short-limbed stature with immunodeficiency (D82.2)
- short stature (child) (R62.52)
- short stature NOS (R62.52)
E35 Disorders of endocrine glands in diseases classified elsewhere
- Echinococcus granulosus infection of thyroid gland (B67.3)
- meningococcal hemorrhagic adrenalitis (A39.1)
- syphilis of endocrine gland (A52.79)
- tuberculosis of adrenal gland, except calcification (A18.7)
- tuberculosis of endocrine gland NEC (A18.82)
- tuberculosis of thyroid gland (A18.81)
- Waterhouse-Friderichsen syndrome (A39.1)
E36.0 Intraoperative hemorrhage and hematoma of an endocrine system organ or structure complicating a procedure applies to 2 codes
- intraoperative hemorrhage and hematoma of an endocrine system organ or structure due to accidental puncture or laceration during a procedure (E36.1-)
Block note Block E40-E46 Malnutrition applies to 8 codes
- intestinal malabsorption (K90.-)
- sequelae of protein-calorie malnutrition (E64.0)
E40 Kwashiorkor
- marasmic kwashiorkor (E42)
E41 Nutritional marasmus
- marasmic kwashiorkor (E42)
E46 Unspecified protein-calorie malnutrition
- nutritional deficiency NOS (E63.9)
E50 Vitamin A deficiency applies to 10 codes
- sequelae of vitamin A deficiency (E64.1)
E51 Thiamine deficiency applies to 5 codes
- sequelae of thiamine deficiency (E64.8)
E52 Niacin deficiency [pellagra]
- sequelae of niacin deficiency (E64.8)
E53 Deficiency of other B group vitamins applies to 4 codes
- sequelae of vitamin B deficiency (E64.8)
E53.1 Pyridoxine deficiency
- pyridoxine-responsive sideroblastic anemia (D64.3)
E53.8 Deficiency of other specified B group vitamins
- folate deficiency anemia (D52.-)
E54 Ascorbic acid deficiency
- scorbutic anemia (D53.2)
- sequelae of vitamin C deficiency (E64.2)
E55 Vitamin D deficiency applies to 2 codes
- adult osteomalacia (M83.-)
- osteoporosis (M80.-)
- sequelae of rickets (E64.3)
E55.0 Rickets, active
- celiac rickets (K90.0)
- Crohn's rickets (K50.-)
- hereditary vitamin D-dependent rickets (E83.32)
- inactive rickets (E64.3)
- renal rickets (N25.0)
- sequelae of rickets (E64.3)
- vitamin D-resistant rickets (E83.31)
E56 Other vitamin deficiencies applies to 4 codes
- sequelae of other vitamin deficiencies (E64.8)
E56.1 Deficiency of vitamin K
- deficiency of coagulation factor due to vitamin K deficiency (D68.4)
- vitamin K deficiency of newborn (P53)
E58 Dietary calcium deficiency
- disorders of calcium metabolism (E83.5-)
- sequelae of calcium deficiency (E64.8)
E59 Dietary selenium deficiency
- sequelae of selenium deficiency (E64.8)
E61 Deficiency of other nutrient elements applies to 10 codes
- disorders of mineral metabolism (E83.-)
- iodine deficiency related thyroid disorders (E00-E02)
- sequelae of malnutrition and other nutritional deficiencies (E64.-)
E61.1 Iron deficiency
- iron deficiency anemia (D50.-)
E66.01 Morbid (severe) obesity due to excess calories
- morbid (severe) obesity with alveolar hypoventilation (E66.2)
E67 Other hyperalimentation applies to 5 codes
- hyperalimentation NOS (R63.2)
- sequelae of hyperalimentation (E68)
Block note Block E70-E88 Metabolic disorders applies to 286 codes
- androgen insensitivity syndrome (E34.5-)
- congenital adrenal hyperplasia (E25.0)
- hemolytic anemias attributable to enzyme disorders (D55.-)
- Marfan syndrome (Q87.4-)
- 5-alpha-reductase deficiency (E29.1)
E70.2 Disorders of tyrosine metabolism applies to 3 codes
- transitory tyrosinemia of newborn (P74.5)
E70.32 Oculocutaneous albinism applies to 4 codes
- Chediak-Higashi syndrome (E70.330)
- Hermansky-Pudlak syndrome (E70.331)
E71.3 Disorders of fatty-acid metabolism applies to 9 codes
- peroxisomal disorders (E71.5)
- Refsum's disease (G60.1)
- Schilder's disease (G37.0)
E71.313 Glutaric aciduria type II
- glutaric aciduria (type 1) NOS (E72.3)
E71.4 Disorders of carnitine metabolism applies to 6 codes
- Muscle carnitine palmitoyltransferase deficiency (E71.314)
E71.5 Peroxisomal disorders applies to 14 codes
- Schilder's disease (G37.0)
E71.51 Disorders of peroxisome biogenesis applies to 3 codes
- Refsum's disease (G60.1)
E71.511 Neonatal adrenoleukodystrophy
- X-linked adrenoleukodystrophy (E71.42-)
E72 Other disorders of amino-acid metabolism applies to 31 codes
- aromatic amino-acid metabolism (E70.-)
- branched-chain amino-acid metabolism (E71.0-E71.2)
- fatty-acid metabolism (E71.3)
- purine and pyrimidine metabolism (E79.-)
- gout (M1A.-, M10.-)
E72.0 Disorders of amino-acid transport applies to 6 codes
- disorders of tryptophan metabolism (E70.5)
E72.04 Cystinosis
- Fanconi (-de Toni) (-Debré) syndrome without cystinosis (E72.09)
E72.1 Disorders of sulfur-bearing amino-acid metabolism applies to 4 codes
- cystinosis (E72.04)
- cystinuria (E72.01)
- transcobalamin II deficiency (D51.2)
E72.2 Disorders of urea cycle metabolism applies to 5 codes
- disorders of ornithine metabolism (E72.4)
E72.20 Disorder of urea cycle metabolism, unspecified
- hyperammonemia-hyperornithinemia-homocitrullinemia syndrome E72.4
- transient hyperammonemia of newborn (P74.6)
E72.3 Disorders of lysine and hydroxylysine metabolism
- glutaric aciduria type II (E71.313)
- Refsum's disease (G60.1)
- Zellweger syndrome (E71.510)
E72.4 Disorders of ornithine metabolism
- hereditary choroidal dystrophy (H31.2-)
E72.53 Primary hyperoxaluria applies to 3 codes
- secondary hyperoxaluria (E72.54-)
E72.54 Secondary hyperoxaluria applies to 4 codes
- primary hyperoxaluria (E72.53-)
E74 Other disorders of carbohydrate metabolism applies to 24 codes
- diabetes mellitus (E08-E13)
- hypoglycemia NOS (E16.2)
- increased secretion of glucagon (E16.3)
- mucopolysaccharidosis (E76.0-E76.3)
E74.1 Disorders of fructose metabolism applies to 4 codes
- muscle phosphofructokinase deficiency (E74.09)
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
- disorders of pyruvate metabolism and gluconeogenesis with anemia (D55.-)
- Leigh's syndrome (G31.82)
E75 Disorders of sphingolipid metabolism and other lipid storage disorders applies to 26 codes
- mucolipidosis, types I-III (E77.0-E77.1)
- Refsum's disease (G60.1)
E75.2 Other sphingolipidosis applies to 15 codes
- adrenoleukodystrophy [Addison-Schilder] (E71.528)
E78 Disorders of lipoprotein metabolism and other lipidemias applies to 18 codes
- sphingolipidosis (E75.0-E75.3)
E78.2 Mixed hyperlipidemia
- cerebrotendinous cholesterosis [van Bogaert-Scherer- Epstein] (E75.5)
- familial combined hyperlipidemia (E78.49)
E78.7 Disorders of bile acid and cholesterol metabolism applies to 4 codes
- Niemann-Pick disease type C (E75.242)
E79 Disorders of purine and pyrimidine metabolism applies to 7 codes
- Ataxia-telangiectasia (Q87.19)
- Bloom's syndrome (Q82.8)
- Cockayne's syndrome (Q87.19)
- calculus of kidney (N20.0)
- combined immunodeficiency disorders (D81.-)
- Fanconi's anemia (D61.09)
- gout (M1A.-, M10.-)
- orotaciduric anemia (D53.0)
- progeria (E34.8)
- Werner's syndrome (E34.8)
- xeroderma pigmentosum (Q82.1)
E83 Disorders of mineral metabolism applies to 31 codes
- dietary mineral deficiency (E58-E61)
- parathyroid disorders (E20-E21)
- vitamin D deficiency (E55.-)
E83.1 Disorders of iron metabolism applies to 6 codes
- iron deficiency anemia (D50.-)
- sideroblastic anemia (D64.0-D64.3)
E83.11 Hemochromatosis applies to 4 codes
- GALD (P78.84)
- Gestational alloimmune liver disease (P78.84)
- Neonatal hemochromatosis (P78.84)
E83.3 Disorders of phosphorus metabolism and phosphatases applies to 4 codes
- adult osteomalacia (M83.-)
- osteoporosis (M80.-)
E83.31 Familial hypophosphatemia
- vitamin D-deficiency rickets (E55.0)
E83.5 Disorders of calcium metabolism applies to 4 codes
- autoimmune hypoparathyroidism (E20.812)
- autosomal dominant hypocalcemia (E20.810)
- chondrocalcinosis (M11.1-M11.2)
- hungry bone syndrome (E83.81)
- hyperparathyroidism (E21.0-E21.3)
- secondary hypoparathyroidism in diseases classified elsewhere (E20.811)
E84.11 Meconium ileus in cystic fibrosis
- meconium ileus not due to cystic fibrosis (P76.0)
E86 Volume depletion applies to 3 codes
- dehydration of newborn (P74.1)
- postprocedural hypovolemic shock (T81.19)
- traumatic hypovolemic shock (T79.4)
E87 Other disorders of fluid, electrolyte and acid-base balance applies to 14 codes
- diabetes insipidus (E23.2)
- electrolyte imbalance associated with hyperemesis gravidarum (O21.1)
- electrolyte imbalance following ectopic or molar pregnancy (O08.5)
- familial periodic paralysis (G72.3)
- metabolic acidemia in newborn, unspecified (P19.9)
E87.1 Hypo-osmolality and hyponatremia
- syndrome of inappropriate secretion of antidiuretic hormone (E22.2)
E87.2 Acidosis applies to 4 codes
- diabetic acidosis - see categories E08-E10, E11, E13 with ketoacidosis
E87.7 Fluid overload applies to 3 codes
- edema NOS (R60.9)
- fluid retention (R60.9)
E88 Other and unspecified metabolic disorders applies to 24 codes
- histiocytosis X (chronic) (C96.6)
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified applies to 3 codes
- monoclonal gammopathy (of undetermined significance) (D47.2)
- polyclonal hypergammaglobulinemia (D89.0)
- Waldenström macroglobulinemia (C88.00)
E88.1 Lipodystrophy, not elsewhere classified applies to 6 codes
- Whipple's disease (K90.81)
E88.4 Mitochondrial metabolism disorders applies to 5 codes
- disorders of pyruvate metabolism (E74.4)
- Kearns-Sayre syndrome (H49.81)
- Leber's disease (H47.22)
- Leigh's encephalopathy (G31.82)
- Mitochondrial myopathy, NEC (G71.3)
- Reye's syndrome (G93.7)
E88.89 Other specified metabolic disorders
- adult pulmonary Langerhans cell histiocytosis (J84.82)
E88.A Wasting disease (syndrome) due to underlying condition
- cachexia NOS (R64)
- nutritional marasmus (E41)
E89.1 Postprocedural hypoinsulinemia
- transient postprocedural hyperglycemia (R73.9)
- transient postprocedural hypoglycemia (E16.2)

The first view lists notes printed in this chapter (a note on a category or block applies to every code beneath it). The second lists codes of this chapter named by Excludes1 Notes anywhere in the Tabular List, including notes in other chapters.

Questions About Excludes1 Notes

What does an Excludes1 note mean?

An Excludes1 note means “NOT CODED HERE!”: the excluded code should never be used at the same time as the code above the note. It is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition (Section I.A.12.a). The FY 2027 Tabular List has 5,411 of them; 5,284 name other codes, with 5,710 references to 3,528 distinct codes, categories and ranges.

Is there any exception to an Excludes1 note?

Yes: when the two conditions are unrelated to each other. The Guidelines’ example is F45.8, whose Excludes1 note names sleep related teeth grinding (G47.63). A patient with psychogenic dysmenorrhea (an inclusion term of F45.8) and teeth grinding may have both codes reported. If it is not clear whether the conditions are related, query the provider.

Related References

ICD-10-CM Official Guidelines ICD-10-CM Code Lookup ICD-10-CM Codes List Code Lists by Tag

Source: FY 2027 ICD-10-CM Tabular List (CMS and NCHS) and the ICD-10-CM Official Guidelines for Coding and Reporting FY 2027, Section I.A. ICD List is not affiliated with CMS or NCHS.