2026 ICD-10-CM Diagnosis Code E65Localized adiposity

ICD-10-CM Codes›E00–E89›E65-E68›E65

ICD-10-CM E65
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E65 is a billable ICD-10-CM diagnosis code for localized adiposity. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 640 through 641. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
E65
Billable Status
Yes — Valid for Submission
Code Describes
Localized adiposity
Chapter
E65-E68
Overweight, obesity and other hyperalimentation

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE65-E68Overweight, obesity and other hyperalimentation
CategoryE65Localized adiposity
This CodeE65Localized adiposity

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Adverse reaction following injection of substance
  • Excess panniculus of abdomen
  • Excess subcutaneous fat
  • Excess subcutaneous fat of back
  • Excess subcutaneous fat of breast
  • Excess subcutaneous fat of lower limb
  • Excess subcutaneous fat of upper limb
  • Fat hypertrophy
  • Fat hypertrophy due to injection of drug or medicament
  • Fat pad syndrome
  • Insulin adverse reaction
  • Insulin lipohypertrophy
  • Localized adiposity
  • Steatopygia

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Fat pad

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Adiposity
      • localized
    • Excess, excessive, excessively
      • fat
        • localized
    • Fat
      • localized (pad)
    • Fat
      • pad
    • Fatty
      • apron
    • Hypertrophy, hypertrophic
      • fat pad
    • Panniculus adiposus(abdominal)
    • Pannus(allergic) (cornea) (degenerativus) (keratic)
      • abdominal (symptomatic)
    • Redundant, redundancy
      • panniculus (abdominal)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Obesity

Obesity is a disease that means having too much body fat. It is different from being overweight, which means weighing too much. Both terms mean that your weight is greater than what's considered healthy for your height.

The full article covers:

  • What is obesity?
  • What raises your risk of obesity?
  • How is obesity diagnosed?
  • What health problems can obesity cause?
  • What are the treatments for obesity?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E65 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
278.1 Localized adiposity
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E65Overview

Is E65 (Localized adiposity) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report localized adiposity on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E65 group to?

When localized adiposity is the principal diagnosis on an inpatient stay, it groups to MS-DRG 640, 641, with relative weights from 0.7782 to 1.3356 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E65?

Under the General Equivalence Mappings, localized adiposity converts to ICD-9-CM 278.1 (localized adiposity). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.