2027 ICD-10-CM Diagnosis Code E88Other and unspecified metabolic disorders

ICD-10-CM Codes›E00–E89›E70-E88›E88

ICD-10-CM E88
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E88 is a non-billable ICD-10-CM category code for other and unspecified metabolic disorders, so it cannot be submitted on claims. Use a more specific code from this category instead, such as E88.01, E88.02, E88.09, and E88.10.

Code Identity

ICD-10-CM Code
E88
Billable Status
No — Non-Billable Category
Code Describes
Other and unspecified metabolic disorders
Short Description
Other and unspecified metabolic disorders
Same as the full description in the CMS dataset.
Chapter
E70-E88
Metabolic disorders

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE88Other and unspecified metabolic disorders
This CodeE88Other and unspecified metabolic disorders

Specific Coding for Other and unspecified metabolic disordersOverview

Non-specific codes like E88 require more characters. Use one of these billable codes instead:

  • E88.0 for Disorders of plasma-protein metabolism, not elsewhere classified

  • Use E88.01 for Alpha-1-antitrypsin deficiency

  • Use E88.02 for Plasminogen deficiency

  • Use E88.09 for Other disorders of plasma-protein metabolism, not elsewhere classified

  • E88.1 for Lipodystrophy, not elsewhere classified

  • Use E88.10 for Lipodystrophy, unspecified

  • Use E88.11 for Partial lipodystrophy

  • Use E88.12 for Generalized lipodystrophy

  • Use E88.13 for Localized lipodystrophy

  • Use E88.14 for HIV-associated lipodystrophy

  • Use E88.19 for Other lipodystrophy, not elsewhere classified

  • Use E88.2 for Lipomatosis, not elsewhere classified

  • Use E88.3 for Tumor lysis syndrome

  • E88.4 for Mitochondrial metabolism disorders

  • Use E88.40 for Mitochondrial metabolism disorder, unspecified

  • Use E88.41 for MELAS syndrome

  • Use E88.42 for MERRF syndrome

  • Use E88.43 for Disorders of mitochondrial tRNA synthetases

  • Use E88.49 for Other mitochondrial metabolism disorders

  • E88.8 for Other specified metabolic disorders

  • E88.81 for Metabolic syndrome and other insulin resistance

  • Use E88.82 for Obesity due to disruption of MC4R pathway

  • Use E88.89 for Other specified metabolic disorders

  • Use E88.9 for Metabolic disorder, unspecified

  • Use E88.A for Wasting disease (syndrome) due to underlying condition

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E88: its own notes plus those printed at block E70-E88 and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

On E88 itself
  • histiocytosis X (chronic) (C96.6)
From Block E70-E88 Metabolic disorders applies to 286 codes
  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block E70-E88 Metabolic disorders applies to 286 codes
  • Ehlers-Danlos syndromes (Q79.6-)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

  • codes for associated conditions

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Patient EducationClinical

Metabolic Disorders

Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E88Overview

What is the ICD-10 code for other and unspecified metabolic disorders?

E88 is the ICD-10-CM category for other and unspecified metabolic disorders, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is E88 (Other and unspecified metabolic disorders) a billable code?

No. This is a category header that groups the codes for other and unspecified metabolic disorders, and headers cannot be submitted on claims. Claims for other and unspecified metabolic disorders need a more specific code from this category, such as E88.01, E88.02, and E88.09.

Can E88 be reported with C96.6?

Not as a rule. The Excludes1 note on E88 lists "histiocytosis X (chronic) (C96.6)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does E88 need an additional code?

When the condition applies, yes. The Use Additional Code note reads: codes for associated conditions. The additional code is reported after E88.