2026 ICD-10-CM Diagnosis Code E88Other and unspecified metabolic disorders

ICD-10-CM Codes›E00–E89›E70-E88›E88

ICD-10-CM E88
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E88 is a non-billable ICD-10-CM category code for other and unspecified metabolic disorders, so it cannot be submitted on claims. Use a more specific code from this category instead, such as E88.01, E88.02, E88.09, and E88.10.

Code Identity

ICD-10-CM Code
E88
Billable Status
No — Non-Billable Category
Code Describes
Other and unspecified metabolic disorders
Chapter
E70-E88
Metabolic disorders

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE88Other and unspecified metabolic disorders
This CodeE88Other and unspecified metabolic disorders

Specific Coding for Other and unspecified metabolic disordersOverview

Non-specific codes like E88 require more characters. Use one of these billable codes instead:

  • E88.0 for Disorders of plasma-protein metabolism, not elsewhere classified

  • Use E88.01 for Alpha-1-antitrypsin deficiency

  • Use E88.02 for Plasminogen deficiency

  • Use E88.09 for Other disorders of plasma-protein metabolism, not elsewhere classified

  • E88.1 for Lipodystrophy, not elsewhere classified

  • Use E88.10 for Lipodystrophy, unspecified

  • Use E88.11 for Partial lipodystrophy

  • Use E88.12 for Generalized lipodystrophy

  • Use E88.13 for Localized lipodystrophy

  • Use E88.14 for HIV-associated lipodystrophy

  • Use E88.19 for Other lipodystrophy, not elsewhere classified

  • Use E88.2 for Lipomatosis, not elsewhere classified

  • Use E88.3 for Tumor lysis syndrome

  • E88.4 for Mitochondrial metabolism disorders

  • Use E88.40 for Mitochondrial metabolism disorder, unspecified

  • Use E88.41 for MELAS syndrome

  • Use E88.42 for MERRF syndrome

  • Use E88.43 for Disorders of mitochondrial tRNA synthetases

  • Use E88.49 for Other mitochondrial metabolism disorders

  • E88.8 for Other specified metabolic disorders

  • E88.81 for Metabolic syndrome and other insulin resistance

  • Use E88.82 for Obesity due to disruption of MC4R pathway

  • Use E88.89 for Other specified metabolic disorders

  • Use E88.9 for Metabolic disorder, unspecified

  • Use E88.A for Wasting disease (syndrome) due to underlying condition

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Use Additional Code

  • codes for associated conditions

Type 1 Excludes

  • histiocytosis X chronic C96.6

Patient EducationClinical

Metabolic Disorders

Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E88Overview

Is E88 (Other and unspecified metabolic disorders) a billable code?

No. This is a category header that groups the codes for other and unspecified metabolic disorders, and headers cannot be submitted on claims. Claims for other and unspecified metabolic disorders need a more specific code from this category, such as E88.01, E88.02, and E88.09.