2024 ICD-10-CM Diagnosis Code E88

Other and unspecified metabolic disorders

ICD-10-CM Code:
Short Description:
Other and unspecified metabolic disorders
Is Billable?
Not Valid for Submission
Code Navigator:

Code Classification

  • Endocrine, nutritional and metabolic diseases
    • Metabolic disorders
      • Other and unspecified metabolic disorders

E88 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of other and unspecified metabolic disorders. The code is not specific and is NOT valid for the year 2024 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Unspecified diagnosis codes like E88 are acceptable when clinical information is unknown or not available about a particular condition. Although a more specific code is preferable, unspecified codes should be used when such codes most accurately reflect what is known about a patient's condition. Specific diagnosis codes should not be used if not supported by the patient's medical record.

Specific Coding Applicable to Other and unspecified metabolic disorders

Non-specific codes like E88 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for other and unspecified metabolic disorders:

  • E88.0 for Disorders of plasma-protein metabolism, not elsewhere classified - NON-BILLABLE CODE

  • Use E88.01 for Alpha-1-antitrypsin deficiency - BILLABLE CODE

  • Use E88.02 for Plasminogen deficiency - BILLABLE CODE

  • Use E88.09 for Other disorders of plasma-protein metabolism, not elsewhere classified - BILLABLE CODE

  • Use E88.1 for Lipodystrophy, not elsewhere classified - BILLABLE CODE

  • Use E88.2 for Lipomatosis, not elsewhere classified - BILLABLE CODE

  • Use E88.3 for Tumor lysis syndrome - BILLABLE CODE

  • E88.4 for Mitochondrial metabolism disorders - NON-BILLABLE CODE

  • Use E88.40 for Mitochondrial metabolism disorder, unspecified - BILLABLE CODE

  • Use E88.41 for MELAS syndrome - BILLABLE CODE

  • Use E88.42 for MERRF syndrome - BILLABLE CODE

  • Use E88.43 for Disorders of mitochondrial tRNA synthetases - BILLABLE CODE

  • Use E88.49 for Other mitochondrial metabolism disorders - BILLABLE CODE

  • E88.8 for Other specified metabolic disorders - NON-BILLABLE CODE

  • E88.81 for Metabolic syndrome and other insulin resistance - NON-BILLABLE CODE

  • Use E88.89 for Other specified metabolic disorders - BILLABLE CODE

  • Use E88.9 for Metabolic disorder, unspecified - BILLABLE CODE

  • Use E88.A for Wasting disease (syndrome) due to underlying condition - BILLABLE CODE

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.

Use Additional Code

Use Additional Code
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
  • codes for associated conditions

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • histiocytosis X chronic C96.6

Patient Education

Metabolic Disorders

Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues, such as your liver, muscles, and body fat.

A metabolic disorder occurs when abnormal chemical reactions in your body disrupt this process. When this happens, you might have too much of some substances or too little of other ones that you need to stay healthy. There are different groups of disorders. Some affect the breakdown of amino acids, carbohydrates, or lipids. Another group, mitochondrial diseases, affects the parts of the cells that produce the energy.

You can develop a metabolic disorder when some organs, such as your liver or pancreas, become diseased or do not function normally. Diabetes is an example.

[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.