2027 ICD-10-CM Diagnosis Code E22Hyperfunction of pituitary gland

ICD-10-CM Codes›E00–E89›E20-E35›E22

ICD-10-CM E22
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E22 is a non-billable ICD-10-CM category code for hyperfunction of pituitary gland, so it cannot be submitted on claims. Use a more specific code from this category instead, such as E22.0, E22.1, E22.2, and E22.8.

Code Identity

ICD-10-CM Code
E22
Billable Status
No — Non-Billable Category
Code Describes
Hyperfunction of pituitary gland
Short Description
Hyperfunction of pituitary gland
Same as the full description in the CMS dataset.
Chapter
E20-E35
Disorders of other endocrine glands

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE22Hyperfunction of pituitary gland
This CodeE22Hyperfunction of pituitary gland

Specific Coding for Hyperfunction of pituitary glandOverview

Non-specific codes like E22 require more characters. Use one of these billable codes instead:

  • Use E22.0 for Acromegaly and pituitary gigantism

  • Use E22.1 for Hyperprolactinemia

  • Use E22.2 for Syndrome of inappropriate secretion of antidiuretic hormone

  • Use E22.8 for Other hyperfunction of pituitary gland

  • Use E22.9 for Hyperfunction of pituitary gland, unspecified

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E22: its own notes plus those printed at block E20-E35 and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

On E22 itself
  • Cushing's syndrome (E24.-)
  • Nelson's syndrome (E24.1)
  • overproduction of ACTH not associated with Cushing's disease (E27.0)
  • overproduction of pituitary ACTH (E24.0)
  • overproduction of thyroid-stimulating hormone (E05.8-)
From Block E20-E35 Disorders of other endocrine glands applies to 99 codes
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E22, its category, or a range that includes it.

Code First 1

These codes say to code first a condition named in the note, and E22 is one of the conditions named.

  • G63 Polyneuropathy in diseases classified elsewhere
    endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34) names E20-E34, which includes this code

Notes 1

These notes mention E22.

  • Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases
    All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code

Patient EducationClinical

Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E22Overview

What is the ICD-10 code for hyperfunction of pituitary gland?

E22 is the ICD-10-CM category for hyperfunction of pituitary gland, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is E22 (Hyperfunction of pituitary gland) a billable code?

No. This is a category header that groups the codes for hyperfunction of pituitary gland, and headers cannot be submitted on claims. Claims for hyperfunction of pituitary gland need a more specific code from this category, such as E22.0, E22.1, and E22.2.

Can E22 be reported with a code from E24?

Not as a rule. The Excludes1 note on E22 lists "Cushing's syndrome (E24.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).