2022 ICD-10-CM Code E22

Hyperfunction of pituitary gland

Version 2021

Not Valid for Submission

ICD-10:E22
Short Description:Hyperfunction of pituitary gland
Long Description:Hyperfunction of pituitary gland

Code Classification

  • Endocrine, nutritional and metabolic diseases (E00–E90)
    • Disorders of other endocrine glands (E20-E35)
      • Hyperfunction of pituitary gland (E22)

E22 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of hyperfunction of pituitary gland. The code is not specific and is NOT valid for the year 2022 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding for Hyperfunction of pituitary gland

Non-specific codes like E22 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10 codes with a higher level of specificity when coding for hyperfunction of pituitary gland:

  • BILLABLE CODE - Use E22.0 for Acromegaly and pituitary gigantism
  • BILLABLE CODE - Use E22.1 for Hyperprolactinemia
  • BILLABLE CODE - Use E22.2 for Syndrome of inappropriate secretion of antidiuretic hormone
  • BILLABLE CODE - Use E22.8 for Other hyperfunction of pituitary gland
  • BILLABLE CODE - Use E22.9 for Hyperfunction of pituitary gland, unspecified

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code E22:


Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

Information for Patients


Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

With pituitary disorders, you often have too much or too little of one of your hormones. Injuries can cause pituitary disorders, but the most common cause is a pituitary tumor.


[Learn More in MedlinePlus]

Code History

  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016 (First year ICD-10-CM implemented into the HIPAA code set)