2026 ICD-10-CM Diagnosis Code E22Hyperfunction of pituitary gland

ICD-10-CM Codes›E00–E89›E20-E35›E22

ICD-10-CM E22
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E22 is a non-billable ICD-10-CM category code for hyperfunction of pituitary gland, so it cannot be submitted on claims. Use a more specific code from this category instead, such as E22.0, E22.1, E22.2, and E22.8.

Code Identity

ICD-10-CM Code
E22
Billable Status
No — Non-Billable Category
Code Describes
Hyperfunction of pituitary gland
Chapter
E20-E35
Disorders of other endocrine glands

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE22Hyperfunction of pituitary gland
This CodeE22Hyperfunction of pituitary gland

Specific Coding for Hyperfunction of pituitary glandOverview

Non-specific codes like E22 require more characters. Use one of these billable codes instead:

  • Use E22.0 for Acromegaly and pituitary gigantism

  • Use E22.1 for Hyperprolactinemia

  • Use E22.2 for Syndrome of inappropriate secretion of antidiuretic hormone

  • Use E22.8 for Other hyperfunction of pituitary gland

  • Use E22.9 for Hyperfunction of pituitary gland, unspecified

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Type 1 Excludes

  • Cushing's syndrome E24
  • Nelson's syndrome E24.1
  • overproduction of ACTH not associated with Cushing's disease E27.0
  • overproduction of pituitary ACTH E24.0
  • overproduction of thyroid-stimulating hormone E05.8

Patient EducationClinical

Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E22Overview

Is E22 (Hyperfunction of pituitary gland) a billable code?

No. This is a category header that groups the codes for hyperfunction of pituitary gland, and headers cannot be submitted on claims. Claims for hyperfunction of pituitary gland need a more specific code from this category, such as E22.0, E22.1, and E22.2.