ICD-10-CM Code E22

Hyperfunction of pituitary gland

Version 2021 Non-Billable Code

Not Valid for Submission

E22 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of hyperfunction of pituitary gland. The code is NOT valid for the year 2021 for the submission of HIPAA-covered transactions.

ICD-10:E22
Short Description:Hyperfunction of pituitary gland
Long Description:Hyperfunction of pituitary gland

Consider the following ICD-10 codes with a higher level of specificity:

  • E22.0 - Acromegaly and pituitary gigantism
  • E22.1 - Hyperprolactinemia
  • E22.2 - Syndrome of inappropriate secretion of antidiuretic hormone
  • E22.8 - Other hyperfunction of pituitary gland
  • E22.9 - ... unspecified

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code E22:

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Cushing's syndrome E24
  • Nelson's syndrome E24.1
  • overproduction of ACTH not associated with Cushing's disease E27.0
  • overproduction of pituitary ACTH E24.0
  • overproduction of thyroid-stimulating hormone E05.8

Code Classification

  • Endocrine, nutritional and metabolic diseases (E00–E90)
    • Disorders of other endocrine glands (E20-E35)
      • Hyperfunction of pituitary gland (E22)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients


Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

With pituitary disorders, you often have too much or too little of one of your hormones. Injuries can cause pituitary disorders, but the most common cause is a pituitary tumor.

  • ACTH (cosyntropin) stimulation test (Medical Encyclopedia)
  • ACTH blood test (Medical Encyclopedia)
  • Empty sella syndrome (Medical Encyclopedia)
  • Follicle-stimulating hormone (FSH) blood test (Medical Encyclopedia)
  • Gigantism (Medical Encyclopedia)
  • Growth hormone stimulation test (Medical Encyclopedia)
  • Hypopituitarism (Medical Encyclopedia)
  • Luteinizing hormone (LH) blood test (Medical Encyclopedia)
  • Pituitary infarction (Medical Encyclopedia)

[Learn More]