ICD-10-CM Excludes1 Notes · Chapter 3 · FY 2027 D50-D89

Excludes1 Notes in Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism ICD-10-CM

An Excludes1 note means "NOT CODED HERE": the excluded code should never be reported together with the code above the note. In Chapter 3 (D50-D89), notes printed in the chapter name other codes 194 times, and Excludes1 Notes anywhere in the Tabular List name the chapter’s codes 145 times, covering 80 distinct codes, categories and ranges. Switch views to read the list either way.

✓ From the official FY 2027 ICD-10-CM Tabular ListDefinitions follow the Official Guidelines, Section I.A

194

References in Its Notes

145

References to Its Codes

Chapter Codes Named

D50-D89

Chapter 3

Excludes1 Notes by the code that carries the note

71 of 71 shown

D50.0 Iron deficiency anemia secondary to blood loss (chronic)
- acute posthemorrhagic anemia (D62)
- congenital anemia from fetal blood loss (P61.3)
D52 Folate deficiency anemia applies to 4 codes
- folate deficiency without anemia (E53.8)
D53.0 Protein deficiency anemia
- Lesch-Nyhan syndrome (E79.1)
D53.1 Other megaloblastic anemias, not elsewhere classified
- Di Guglielmo's disease (C94.0)
D53.2 Scorbutic anemia
- scurvy (E54)
D53.9 Nutritional anemia, unspecified
- anemia NOS (D64.9)
D55 Anemia due to enzyme disorders applies to 7 codes
- drug-induced enzyme deficiency anemia (D59.2)
D55.0 Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
- glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia (D75.A)
D55.2 Anemia due to disorders of glycolytic enzymes applies to 2 codes
- disorders of glycolysis not associated with anemia (E74.81-)
D56 Thalassemia applies to 8 codes
- sickle-cell thalassemia (D57.4-)
D56.0 Alpha thalassemia
- alpha thalassemia trait or minor (D56.3)
- asymptomatic alpha thalassemia (D56.3)
- hydrops fetalis due to isoimmunization (P56.0)
- hydrops fetalis not due to immune hemolysis (P83.2)
D56.1 Beta thalassemia
- beta thalassemia minor (D56.3)
- beta thalassemia trait (D56.3)
- delta-beta thalassemia (D56.2)
- hemoglobin E-beta thalassemia (D56.5)
- sickle-cell beta thalassemia (D57.4-)
D56.2 Delta-beta thalassemia
- delta-beta thalassemia minor (D56.3)
- delta-beta thalassemia trait (D56.3)
D56.3 Thalassemia minor
- alpha thalassemia (D56.0)
- beta thalassemia (D56.1)
- delta-beta thalassemia (D56.2)
- hemoglobin E-beta thalassemia (D56.5)
- sickle-cell trait (D57.3)
D56.5 Hemoglobin E-beta thalassemia
- beta thalassemia (D56.1)
- beta thalassemia minor (D56.3)
- beta thalassemia trait (D56.3)
- delta-beta thalassemia (D56.2)
- delta-beta thalassemia trait (D56.3)
- hemoglobin E disease (D58.2)
- other hemoglobinopathies (D58.2)
- sickle-cell beta thalassemia (D57.4-)
D56.8 Other thalassemias
- hemoglobin C disease (D58.2)
- hemoglobin E disease (D58.2)
- other hemoglobinopathies (D58.2)
- sickle-cell anemia (D57.-)
- sickle-cell thalassemia (D57.4-)
D57 Sickle-cell disorders applies to 43 codes
- other hemoglobinopathies (D58.-)
D58 Other hereditary hemolytic anemias applies to 5 codes
- hemolytic anemia of the newborn (P55.-)
D58.2 Other hemoglobinopathies
- familial polycythemia (D75.0)
- Hb-M disease (D74.0)
- hemoglobin E-beta thalassemia (D56.5)
- hereditary persistence of fetal hemoglobin [HPFH] (D56.4)
- high-altitude polycythemia (D75.1)
- methemoglobinemia (D74.-)
- other hemoglobinopathies with thalassemia (D56.8)
D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
- hemoglobinuria NOS (R82.3)
D59.6 Hemoglobinuria due to hemolysis from other external causes
- hemoglobinuria NOS (R82.3)
D60 Acquired pure red cell aplasia [erythroblastopenia] applies to 4 codes
- congenital red cell aplasia (D61.01)
D61.01 Constitutional (pure) red blood cell aplasia
- acquired red cell aplasia (D60.9)
D61.03 Fanconi anemia
- Fanconi syndrome (E72.0-)
D61.81 Pancytopenia applies to 3 codes
- pancytopenia (due to) (with) aplastic anemia (D61.9)
- pancytopenia (due to) (with) bone marrow infiltration (D61.82)
- pancytopenia (due to) (with) congenital (pure) red cell aplasia (D61.01)
- pancytopenia (due to) (with) hairy cell leukemia (C91.4-)
- pancytopenia (due to) (with) human immunodeficiency virus disease (B20.-)
- pancytopenia (due to) (with) leukoerythroblastic anemia (D61.82)
- pancytopenia (due to) (with) myeloproliferative disease (D47.1)
D61.82 Myelophthisis
- idiopathic myelofibrosis (D47.1)
- myelofibrosis NOS (D75.81)
- myelofibrosis with myeloid metaplasia (D47.4)
- primary myelofibrosis (D47.1)
- secondary myelofibrosis (D75.81)
D62 Acute posthemorrhagic anemia
- anemia due to chronic blood loss (D50.0)
- blood loss anemia NOS (D50.0)
- congenital anemia from fetal blood loss (P61.3)
D63.0 Anemia in neoplastic disease
- aplastic anemia due to antineoplastic chemotherapy (D61.1)
D64 Other anemias applies to 8 codes
- refractory anemia (D46.-)
- refractory anemia with excess blasts in transformation [RAEB T] (C92.0-)
D64.4 Congenital dyserythropoietic anemia
- Blackfan-Diamond syndrome (D61.01)
- Di Guglielmo's disease (C94.0)
D65 Disseminated intravascular coagulation [defibrination syndrome]
- in newborn (P60)
- pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)
D66 Hereditary factor VIII deficiency
- factor VIII deficiency with vascular defect (D68.0-)
D68 Other coagulation defects applies to 25 codes
- abnormal coagulation profile NOS (R79.1)
D68.0 Von Willebrand disease applies to 10 codes
- capillary fragility (hereditary) (D69.8)
- factor VIII deficiency NOS (D66)
- factor VIII deficiency with functional defect (D66)
D68.312 Antiphospholipid antibody with hemorrhagic disorder
- antiphospholipid antibody, finding without diagnosis (R76.0)
- lupus anticoagulant (LAC) finding without diagnosis (R76.0)
- systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
D68.4 Acquired coagulation factor deficiency
- vitamin K deficiency of newborn (P53)
D68.5 Primary thrombophilia applies to 3 codes
- antiphospholipid syndrome (D68.61)
- lupus anticoagulant (D68.62)
- secondary activated protein C resistance (D68.69)
- secondary antiphospholipid antibody syndrome (D68.69)
- secondary lupus anticoagulant with hypercoagulable state (D68.69)
- secondary systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.69)
- systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
- systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder (D68.312)
- thrombotic thrombocytopenic purpura (M31.19)
D68.6 Other thrombophilia applies to 3 codes
- diffuse or disseminated intravascular coagulation [DIC] (D65)
- heparin induced thrombocytopenia (HIT) (D75.82-)
- hyperhomocysteinemia (E72.11)
D68.61 Antiphospholipid syndrome
- anti-phospholipid antibody, finding without diagnosis (R76.0)
D68.62 Lupus anticoagulant syndrome
- lupus anticoagulant (LAC) finding without diagnosis (R76.0)
D68.8 Other specified coagulation defects
- hemorrhagic disease of newborn (P53)
D69 Purpura and other hemorrhagic conditions applies to 13 codes
- benign hypergammaglobulinemic purpura (D89.0)
- cryoglobulinemic purpura (D89.1)
- essential (hemorrhagic) thrombocythemia (D47.3)
- hemorrhagic thrombocythemia (D47.3)
- purpura fulminans (D65)
- thrombotic thrombocytopenic purpura (M31.19)
- Waldenström hypergammaglobulinemic purpura (D89.0)
D69.0 Allergic purpura
- thrombocytopenic hemorrhagic purpura (D69.3)
D69.1 Qualitative platelet defects applies to 2 codes
- hemolytic-uremic syndrome (D59.3-)
D69.4 Other primary thrombocytopenia applies to 3 codes
- transient neonatal thrombocytopenia (P61.0)
- Wiskott-Aldrich syndrome (D82.0)
D69.5 Secondary thrombocytopenia applies to 2 codes
- heparin induced thrombocytopenia (HIT) (D75.82-)
- transient thrombocytopenia of newborn (P61.0)
D70 Neutropenia applies to 7 codes
- neutropenic splenomegaly (D73.81)
- transient neonatal neutropenia (P61.5)
D72 Other disorders of white blood cells applies to 22 codes
- basophilia (D72.824)
- immunity disorders (D80-D89)
- preleukemia (syndrome) (D46.9)
D72.0 Genetic anomalies of leukocytes
- Chédiak (-Steinbrinck)-Higashi syndrome (E70.330)
D72.8 Other specified disorders of white blood cells applies to 12 codes
- leukemia (C91-C95)
D72.82 Elevated white blood cell count applies to 8 codes
- eosinophilia (D72.1)
D72.821 Monocytosis (symptomatic)
- infectious mononucleosis (B27.-)
D72.825 Bandemia
- leukemia (C91.-, C92.-, C93.-, C94.-, C95.-)
D73.0 Hyposplenism
- asplenia (congenital) (Q89.01)
- postsurgical absence of spleen (Z90.81)
D73.1 Hypersplenism
- neutropenic splenomegaly (D73.81)
- primary splenic neutropenia (D73.81)
- splenitis, splenomegaly in late syphilis (A52.79)
- splenitis, splenomegaly in tuberculosis (A18.85)
- splenomegaly NOS (R16.1)
- splenomegaly congenital (Q89.0)
D73.5 Infarction of spleen
- rupture of spleen due to Plasmodium vivax malaria (B51.0)
- traumatic rupture of spleen (S36.03-)
D75.0 Familial erythrocytosis
- hereditary ovalocytosis (D58.1)
D75.1 Secondary polycythemia
- polycythemia neonatorum (P61.1)
- polycythemia vera (D45)
D75.81 Myelofibrosis
- acute myelofibrosis (C94.4-)
- idiopathic myelofibrosis (D47.1)
- leukoerythroblastic anemia (D61.82)
- myelofibrosis with myeloid metaplasia (D47.4)
- myelophthisic anemia (D61.82)
- myelophthisis (D61.82)
- primary myelofibrosis (D47.1)
D75.A Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia
- glucose-6-phosphate dehydrogenase (G6PD) deficiency with anemia (D55.0)
D76 Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue applies to 3 codes
- (Abt-) Letterer-Siwe disease (C96.0)
- eosinophilic granuloma (C96.6)
- Hand-Schüller-Christian disease (C96.5)
- histiocytic medullary reticulosis (C96.9)
- histiocytic sarcoma (C96.A)
- histiocytosis X, multifocal (C96.5)
- histiocytosis X, unifocal (C96.6)
- Langerhans-cell histiocytosis, multifocal (C96.5)
- Langerhans-cell histiocytosis NOS (C96.6)
- Langerhans-cell histiocytosis, unifocal (C96.6)
- leukemic reticuloendotheliosis (C91.4-)
- lipomelanotic reticulosis (I89.8)
- malignant histiocytosis (C96.A)
- malignant reticulosis (C86.0)
- nonlipid reticuloendotheliosis (C96.0)
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
- rupture of spleen due to Plasmodium vivax malaria (B51.0)
- splenitis, splenomegaly in late syphilis (A52.79)
- splenitis, splenomegaly in tuberculosis (A18.85)
D78.0 Intraoperative hemorrhage and hematoma of the spleen complicating a procedure applies to 2 codes
- intraoperative hemorrhage and hematoma of the spleen due to accidental puncture or laceration during a procedure (D78.1-)
Block note Block D80-D89 Certain disorders involving the immune mechanism applies to 83 codes
- autoimmune disease (systemic) NOS (M35.9)
- functional disorders of polymorphonuclear neutrophils (D71-)
D81 Combined immunodeficiencies applies to 17 codes
- autosomal recessive agammaglobulinemia (Swiss type) (D80.0)
D81.81 Biotin-dependent carboxylase deficiency applies to 3 codes
- biotin-dependent carboxylase deficiency due to dietary deficiency of biotin (E53.8)
D82 Immunodeficiency associated with other major defects applies to 7 codes
- ataxia telangiectasia [Louis-Bar] (G11.3)
D84.81 Immunodeficiency due to conditions classified elsewhere
- certain disorders involving the immune mechanism (D80-D83, D84.0, D84.1, D84.9)
- human immunodeficiency virus [HIV] disease (B20)
D89 Other disorders involving the immune mechanism, not elsewhere classified applies to 24 codes
- hyperglobulinemia NOS (R77.1)
- monoclonal gammopathy (of undetermined significance) (D47.2)
D89.4 Mast cell activation syndrome and related disorders applies to 6 codes
- aggressive systemic mastocytosis (C96.21)
- congenital cutaneous mastocytosis (Q82.2)
- (non-congenital) cutaneous mastocytosis (D47.01)
- (indolent) systemic mastocytosis (D47.02)
- malignant mast cell neoplasm (C96.2-)
- malignant mastocytoma (C96.29)
- mast cell leukemia (C94.3-)
- mast cell sarcoma (C96.22)
- mastocytoma NOS (D47.09)
- other mast cell neoplasms of uncertain behavior (D47.09)
- systemic mastocytosis associated with a clonal hematologic non-mast cell lineage disease (SM-AHNMD) (D47.02)
D89.89 Other specified disorders involving the immune mechanism, not elsewhere classified
- human immunodeficiency virus disease (B20)

The first view lists notes printed in this chapter (a note on a category or block applies to every code beneath it). The second lists codes of this chapter named by Excludes1 Notes anywhere in the Tabular List, including notes in other chapters.

Questions About Excludes1 Notes

What does an Excludes1 note mean?

An Excludes1 note means “NOT CODED HERE!”: the excluded code should never be used at the same time as the code above the note. It is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition (Section I.A.12.a). The FY 2027 Tabular List has 5,411 of them; 5,284 name other codes, with 5,710 references to 3,528 distinct codes, categories and ranges.

Is there any exception to an Excludes1 note?

Yes: when the two conditions are unrelated to each other. The Guidelines’ example is F45.8, whose Excludes1 note names sleep related teeth grinding (G47.63). A patient with psychogenic dysmenorrhea (an inclusion term of F45.8) and teeth grinding may have both codes reported. If it is not clear whether the conditions are related, query the provider.

Related References

ICD-10-CM Official Guidelines ICD-10-CM Code Lookup ICD-10-CM Codes List Code Lists by Tag

Source: FY 2027 ICD-10-CM Tabular List (CMS and NCHS) and the ICD-10-CM Official Guidelines for Coding and Reporting FY 2027, Section I.A. ICD List is not affiliated with CMS or NCHS.