ICD-10-CM Code E23.2

Diabetes insipidus

Version 2021 Billable Code

Valid for Submission

E23.2 is a billable code used to specify a medical diagnosis of diabetes insipidus. The code is valid for the fiscal year 2021 for the submission of HIPAA-covered transactions. The ICD-10-CM code E23.2 might also be used to specify conditions or terms like bilateral optic atrophy of eyes, diabetes insipidus, diabetes mellitus and insipidus with optic atrophy and deafness, dipsogenic diabetes insipidus, familial central diabetes insipidus, familial diabetes insipidus, etc

Short Description:Diabetes insipidus
Long Description:Diabetes insipidus

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code E23.2:

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • nephrogenic diabetes insipidus N25.1

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code E23.2 are found in the index:


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Bilateral optic atrophy of eyes
  • Diabetes insipidus
  • Diabetes mellitus AND insipidus with optic atrophy AND deafness
  • Dipsogenic diabetes insipidus
  • Familial central diabetes insipidus
  • Familial diabetes insipidus
  • Familial diabetes insipidus
  • Hypohidrosis
  • Hypohidrosis-diabetes insipidus syndrome
  • Idiopathic diabetes insipidus
  • Leber's amaurosis
  • Neurohypophyseal diabetes insipidus
  • Optic atrophy of left eye
  • Optic atrophy of right eye
  • Partial diabetes insipidus
  • Polyuric state
  • Secondary diabetes insipidus
  • Spastic tetraparesis
  • Tetraparesis
  • X-linked intellectual disability, limb spasticity, retinal dystrophy, diabetes insipidus syndrome

Clinical Information

  • DIABETES INSIPIDUS-. a disease that is characterized by frequent urination excretion of large amounts of dilute urine and excessive thirst. etiologies of diabetes insipidus include deficiency of antidiuretic hormone also known as adh or vasopressin secreted by the neurohypophysis impaired kidney response to adh and impaired hypothalamic regulation of thirst.
  • WOLFRAM SYNDROME-. a hereditary condition characterized by multiple symptoms including those of diabetes insipidus; diabetes mellitus; optic atrophy; and deafness. this syndrome is also known as didmoad first letter of each word and is usually associated with vasopressin deficiency. it is caused by mutations in gene wfs1 encoding wolframin a 100 kda transmembrane protein.
  • DIABETES INSIPIDUS NEPHROGENIC-. a genetic or acquired polyuric disorder characterized by persistent hypotonic urine and hypokalemia. this condition is due to renal tubular insensitivity to vasopressin and failure to reduce urine volume. it may be the result of mutations of genes encoding vasopressin receptors or aquaporin 2; kidney diseases; adverse drug effects; or complications from pregnancy.
  • DIABETES INSIPIDUS NEUROGENIC-. a genetic or acquired polyuric disorder caused by a deficiency of vasopressins secreted by the neurohypophysis. clinical signs include the excretion of large volumes of dilute urine; hypernatremia; thirst; and polydipsia. etiologies include head trauma; surgeries and diseases involving the hypothalamus and the pituitary gland. this disorder may also be caused by mutations of genes such as arvp encoding vasopressin and its corresponding neurophysin neurophysins.

Diagnostic Related Groups

The ICD-10 code E23.2 is grouped in the following groups for version MS-DRG V38.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2020 through 09/30/2021.


Convert E23.2 to ICD-9

  • 253.5 - Diabetes insipidus

Code Classification

  • Endocrine, nutritional and metabolic diseases (E00–E90)
    • Disorders of other endocrine glands (E20-E35)
      • Hypofunction and other disorders of the pituitary gland (E23)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients

Diabetes Insipidus

Also called: DI

Diabetes insipidus (DI) causes frequent urination. You become extremely thirsty, so you drink. Then you urinate. This cycle can keep you from sleeping or even make you wet the bed. Your body produces lots of urine that is almost all water.

DI is different from diabetes mellitus (DM), which involves insulin problems and high blood sugar. The symptoms can be similar. However, DI is related to how your kidneys handle fluids. It's much less common than DM. Urine and blood tests can show which one you have.

Usually, DI is caused by a problem with your pituitary gland or your kidneys. Treatment depends on the cause of the problem. Medicines can often help.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

  • Diabetes insipidus (Medical Encyclopedia)
  • Diabetes insipidus - central (Medical Encyclopedia)
  • Diabetes insipidus - nephrogenic (Medical Encyclopedia)

[Learn More]

Neurohypophyseal diabetes insipidus Neurohypophyseal diabetes insipidus is a disorder of water balance. The body normally balances fluid intake with the excretion of fluid in urine. However, people with neurohypophyseal diabetes insipidus produce too much urine (polyuria), which causes them to be excessively thirsty (polydipsia). Affected people need to urinate frequently, which can disrupt daily activities and sleep.People with neurohypophyseal diabetes insipidus can quickly become dehydrated if they do not drink enough water. Dehydration can lead to constipation and dry skin. If the disorder is not treated, more serious complications of dehydration can occur. These include confusion, low blood pressure, seizures, and coma.Neurohypophyseal diabetes insipidus can be either acquired or familial. The acquired form is brought on by injuries, tumors, and other factors, and can occur at any time during life. The familial form is caused by genetic mutations; its signs and symptoms usually become apparent in childhood and worsen over time.Neurohypophyseal diabetes insipidus should not be confused with diabetes mellitus, which is much more common. Diabetes mellitus is characterized by high blood sugar levels resulting from a shortage of the hormone insulin or an insensitivity to this hormone. Although neurohypophyseal diabetes insipidus and diabetes mellitus have some features in common, they are separate disorders with different causes.
[Learn More]