2024 ICD-10-CM Diagnosis Code E23.2

Diabetes insipidus

ICD-10-CM Code:
ICD-10 Code for:
Diabetes insipidus
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Code Navigator:

Code Classification

  • Endocrine, nutritional and metabolic diseases
    • Disorders of other endocrine glands
      • Hypofunction and other disorders of the pituitary gland

E23.2 is a billable diagnosis code used to specify a medical diagnosis of diabetes insipidus. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Bilateral optic atrophy of eyes
  • Diabetes insipidus
  • Dipsogenic diabetes insipidus
  • Familial central diabetes insipidus
  • Familial diabetes insipidus
  • Familial diabetes insipidus
  • Hypohidrosis
  • Hypohidrosis-diabetes insipidus syndrome
  • Idiopathic diabetes insipidus
  • Leber's amaurosis
  • Muscle weakness of upper limb
  • Neurohypophyseal diabetes insipidus
  • Neurohypophyseal diabetes insipidus
  • Neurohypophyseal diabetes insipidus
  • Paresis of left lower limb
  • Paresis of right lower limb
  • Partial diabetes insipidus
  • Polyuric state
  • Postoperative central diabetes insipidus
  • Post-traumatic central diabetes insipidus
  • Secondary diabetes insipidus
  • Spastic tetraparesis
  • Tetraparesis
  • Weakness of bilateral lower limb
  • Weakness of left lower limb
  • Weakness of left upper limb
  • Weakness of right lower limb
  • Weakness of right upper limb
  • Wolfram syndrome
  • X-linked intellectual disability, limb spasticity, retinal dystrophy, diabetes insipidus syndrome

Clinical Classification

Clinical Information

  • Diabetes Insipidus

    a disease that is characterized by frequent urination, excretion of large amounts of dilute urine, and excessive thirst. etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as adh or vasopressin) secreted by the neurohypophysis, impaired kidney response to adh, and impaired hypothalamic regulation of thirst.
  • Diabetes Insipidus, Nephrogenic

    a genetic or acquired polyuric disorder characterized by persistent hypotonic urine and hypokalemia. this condition is due to renal tubular insensitivity to vasopressin and failure to reduce urine volume. it may be the result of mutations of genes encoding vasopressin receptors or aquaporin-2; kidney diseases; adverse drug effects; or complications from pregnancy.
  • Diabetes Insipidus, Neurogenic

    a genetic or acquired polyuric disorder caused by a deficiency of vasopressins secreted by the neurohypophysis. clinical signs include the excretion of large volumes of dilute urine; hypernatremia; thirst; and polydipsia. etiologies include head trauma; surgeries and diseases involving the hypothalamus and the pituitary gland. this disorder may also be caused by mutations of genes such as arvp encoding vasopressin and its corresponding neurophysin (neurophysins).
  • Wolfram Syndrome

    a hereditary condition characterized by multiple symptoms including those of diabetes insipidus; diabetes mellitus; optic atrophy; and deafness. this syndrome is also known as didmoad (first letter of each word) and is usually associated with vasopressin deficiency. it is caused by mutations in gene wfs1 encoding wolframin, a 100-kda transmembrane protein.
  • Hypohidrosis

    abnormally diminished or absent perspiration. both generalized and segmented (reduced or absent sweating in circumscribed locations) forms of the disease are usually associated with other underlying conditions.
  • Adipsic Diabetes Insipidus

    diabetes insipidus complicated by a deficient or absent thirst response to hyperosmolality, usually as a result of hypothalamic damage or dysfunction.
  • Autosomal Dominant Neurohypophyseal Diabetes Insipidus|ADNDI

    an autosomal dominant form of diabetes insipidus caused by mutation(s) in the avp gene encoding arginine vasopressin.
  • AVP wt Allele|ADH|ARVP|AVP|AVP-NPII|AVRP|Arginine Vasopressin (Neurophysin II, Antidiuretic Hormone, Diabetes Insipidus, Neurohypophyseal) Gene|Arginine Vasopressin wt Allele|VP

    human avp wild-type allele is located in the vicinity of 20p13 and is approximately 3 kb in length. this allele, which encodes vasopressin-neurophysin 2-copeptin protein, is involved in the mediation of a wide variety of bodily functions. mutations in the gene results in autosomal dominant neurohypophyseal diabetes insipidus.
  • AVPR2 wt Allele|ADHR|Arginine Vasopressin Receptor 2 (Nephrogenic Diabetes Insipidus) Gene|Arginine Vasopressin Receptor 2 wt Allele|DI1|DIR|DIR3|NDI|V2R

    human avpr2 wild-type allele is located within xq28 and is approximately 5 kb in length. this allele, which encodes vasopressin v2 receptor protein, is involved in the maintenance of water homeostasis and g protein-coupled receptor signal transduction. when the function of the gene is absent, it results in nephrogenic diabetes insipidus (ndi).
  • Diabetes Insipidus

    a disorder characterized by excretion of large amounts of urine, accompanied by excessive thirst. causes include deficiency of antidiuretic hormone or failure of the kidneys to respond to antidiuretic hormone. it may also be drug-related.
  • Dipsogenic Diabetes Insipidus|Primary Polydipsia

    diabetes insipidus caused by excessive intake of water due to psychological factors or damage to the thirst-regulating mechanism.
  • Nephrogenic Diabetes Insipidus

    diabetes insipidus caused by insensitivity of the kidneys to antidiuretic hormone.
  • Neurogenic Diabetes Insipidus|ADH Deficiency|AVP deficiency|Antidiuretic Hormone Deficiency|Arginine Vasopressin Deficiency|Central Diabetes Insipidus|Vasopressin Deficiency

    diabetes insipidus caused by decreased secretion of antidiuretic hormone from the pituitary gland.
  • Wolfram Syndrome|DIDMOAD|DIDMOAD|Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness Syndrome

    a rare inherited syndrome caused by mutations in the wfs1 and cisd2 genes. it is characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness.
  • Grade 2 Hypohidrosis, CTCAE|Grade 2 Hypohidrosis

    symptomatic; limiting instrumental adl
  • Grade 3 Hypohidrosis, CTCAE|Grade 3 Hypohidrosis

    increase in body temperature; limiting self care adl
  • Grade 4 Hypohidrosis, CTCAE|Grade 4 Hypohidrosis

    heat stroke
  • Grade 5 Hypohidrosis, CTCAE|Grade 5 Hypohidrosis

  • Hypohidrosis

    reduced sweating. causes include burns, dehydration, radiation, and leprosy.
  • Hypohidrosis, CTCAE|Hypohidrosis|Hypohidrosis

    a disorder characterized by reduced sweating.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • nephrogenic diabetes insipidus N25.1

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert E23.2 to ICD-9-CM

  • ICD-9-CM Code: 253.5 - Diabetes insipidus

Patient Education

Diabetes Insipidus

Diabetes insipidus (DI) causes frequent urination. You become extremely thirsty, so you drink. Then you urinate. This cycle can keep you from sleeping or even make you wet the bed. Your body produces lots of urine that is almost all water.

DI is different from diabetes mellitus (DM), which involves insulin problems and high blood sugar. The symptoms can be similar. However, DI is related to how your kidneys handle fluids. It's much less common than DM. Urine and blood tests can show which one you have.

Usually, DI is caused by a problem with your pituitary gland or your kidneys. Treatment depends on the cause of the problem. Medicines can often help.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

[Learn More in MedlinePlus]

Neurohypophyseal diabetes insipidus

Neurohypophyseal diabetes insipidus is a disorder of water balance. The body normally balances fluid intake with the excretion of fluid in urine. However, people with neurohypophyseal diabetes insipidus produce too much urine (polyuria), which causes them to be excessively thirsty (polydipsia). Affected people need to urinate frequently, which can disrupt daily activities and sleep.

People with neurohypophyseal diabetes insipidus can quickly become dehydrated if they do not drink enough water. Dehydration can lead to constipation and dry skin. If the disorder is not treated, more serious complications of dehydration can occur. These include confusion, low blood pressure, seizures, and coma.

Neurohypophyseal diabetes insipidus can be either acquired or familial. The acquired form is brought on by injuries, tumors, and other factors, and can occur at any time during life. The familial form is caused by genetic mutations; its signs and symptoms usually become apparent in childhood and worsen over time.

Neurohypophyseal diabetes insipidus should not be confused with diabetes mellitus, which is much more common. Diabetes mellitus is characterized by high blood sugar (glucose) levels resulting from a shortage of the hormone insulin or an insensitivity to this hormone. Although neurohypophyseal diabetes insipidus and diabetes mellitus have some features in common, they are separate disorders with different causes.

[Learn More in MedlinePlus]

Diabetes Insipidus

Learn about the different types of diabetes insipidus, their causes, and how they are diagnosed and treated.
[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.


[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.