ICD-10-CM Code E27.1

Primary adrenocortical insufficiency

Version 2020 Billable Code

Valid for Submission

E27.1 is a billable code used to specify a medical diagnosis of primary adrenocortical insufficiency. The code is valid for the year 2020 for the submission of HIPAA-covered transactions. The ICD-10-CM code E27.1 might also be used to specify conditions or terms like addison's disease, addison's disease due to autoimmunity, adrenomyodystrophy, buccal pigmentation due to addison's disease, congenital hypoplasia of adrenal gland, congenital primary adrenocortical hypofunction, etc

ICD-10:E27.1
Short Description:Primary adrenocortical insufficiency
Long Description:Primary adrenocortical insufficiency

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code E27.1:

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Addison's disease
  • Autoimmune adrenalitis

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Addison only phenotype adrenoleukodystrophy E71.528
  • amyloidosis E85
  • tuberculous Addison's disease A18.7
  • Waterhouse-Friderichsen syndrome A39.1

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code E27.1 are found in the index:


Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Addison's disease
  • Addison's disease due to autoimmunity
  • Adrenomyodystrophy
  • Buccal pigmentation due to Addison's disease
  • Congenital hypoplasia of adrenal gland
  • Congenital primary adrenocortical hypofunction
  • Familial glucocorticoid deficiency
  • Hereditary adrenal unresponsiveness to corticotropin
  • Hypermelanosis due to endocrine disorder
  • Inherited isolated adrenal insufficiency due to partial CYP11A1 deficiency
  • Myopathy in Addison's disease
  • Primary adrenocortical insufficiency
  • Primary immunodeficiency with natural killer cell deficiency and adrenal insufficiency

Clinical Information

  • ADDISON DISEASE-. an adrenal disease characterized by the progressive destruction of the adrenal cortex resulting in insufficient production of aldosterone and hydrocortisone. clinical symptoms include anorexia; nausea; weight loss; muscle weakness; and hyperpigmentation of the skin due to increase in circulating levels of acth precursor hormone which stimulates melanocytes.

Diagnostic Related Groups

The ICD-10 code E27.1 is grouped in the following groups for version MS-DRG V37.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2020 through 09/30/2020.

  • 643 - ENDOCRINE DISORDERS WITH MCC
  • 644 - ENDOCRINE DISORDERS WITH CC
  • 645 - ENDOCRINE DISORDERS WITHOUT CC/MCC

Convert E27.1 to ICD-9

  • 255.41 - Glucocorticoid deficient (Approximate Flag)

Code Classification

  • Endocrine, nutritional and metabolic diseases (E00–E90)
    • Disorders of other endocrine glands (E20-E35)
      • Other disorders of adrenal gland (E27)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients


Addison Disease

Your adrenal glands are just above your kidneys. The outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. Addison disease happens if the adrenal glands don't make enough of these hormones.

A problem with your immune system usually causes Addison disease. The immune system mistakenly attacks your own tissues, damaging your adrenal glands. Other causes include infections and cancer.

Symptoms include

  • Weight loss
  • Muscle weakness
  • Fatigue that gets worse over time
  • Low blood pressure
  • Patchy or dark skin

Lab tests can confirm that you have Addison disease. If you don't treat it, it can be fatal. You will need to take hormone pills for the rest of your life. If you have Addison disease, you should carry an emergency ID. It should say that you have the disease, list your medicines and say how much you need in an emergency.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases


[Learn More]

Autoimmune Addison disease Autoimmune Addison disease affects the function of the adrenal glands, which are small hormone-producing glands located on top of each kidney. It is classified as an autoimmune disorder because it results from a malfunctioning immune system that attacks the adrenal glands. As a result, the production of several hormones is disrupted, which affects many body systems.The signs and symptoms of autoimmune Addison disease can begin at any time, although they most commonly begin between ages 30 and 50. Common features of this condition include extreme tiredness (fatigue), nausea, decreased appetite, and weight loss. In addition, many affected individuals have low blood pressure (hypotension), which can lead to dizziness when standing up quickly; muscle cramps; and a craving for salty foods. A characteristic feature of autoimmune Addison disease is abnormally dark areas of skin (hyperpigmentation), especially in regions that experience a lot of friction, such as the armpits, elbows, knuckles, and palm creases. The lips and the inside lining of the mouth can also be unusually dark. Because of an imbalance of hormones involved in development of sexual characteristics, women with this condition may lose their underarm and pubic hair.Other signs and symptoms of autoimmune Addison disease include low levels of sugar (hypoglycemia) and sodium (hyponatremia) and high levels of potassium (hyperkalemia) in the blood. Affected individuals may also have a shortage of red blood cells (anemia) and an increase in the number of white blood cells (lymphocytosis), particularly those known as eosinophils (eosinophilia).Autoimmune Addison disease can lead to a life-threatening adrenal crisis, characterized by vomiting, abdominal pain, back or leg cramps, and severe hypotension leading to shock. The adrenal crisis is often triggered by a stressor, such as surgery, trauma, or infection.Individuals with autoimmune Addison disease or their family members can have another autoimmune disorder, most commonly autoimmune thyroid disease or type 1 diabetes.
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