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New 2025 ICD-10-CM Diagnosis Codes List

For the 2025 fiscal year, the ICD-10-CM diagnosis codes system has been updated with 225 new codes, of which 212 are new billable codes.

Significant updates were made to Chapter 2 - Neoplasms (C00–D49). New diagnosis codes were introduced to specify a variety of neoplasms in remission. This chapter received a total of 63 new codes.

Chapter 13 - Diseases of the musculoskeletal system and connective tissue (M00-M99) added 33 new codes to specify synovitis and tenosynovitis.

Chapter 11: Diseases of the digestive system has been updated also with 27 new diagnosis codes. The new codes in this chapter specify fistula conditions in different parts of the body.

Here is a summary of the new codes added this year:


Chapter 2: Neoplasms (C00–D49)

  • C83.9A - Non-follicular (diffuse) lymphoma, unspecified, in remission
  • C84.1A - Sezary disease, in remission
  • C85.2A - Mediastinal (thymic) large B-cell lymphoma, in remission
  • C86.21 - Enteropathy-type (intestinal) T-cell lymphoma, in remission
  • C82.1A - Follicular lymphoma grade II, in remission
  • C88.00 - Waldenstrom macroglobulinemia not having achieved remission
  • C86.61 - Primary cutaneous CD30-positive T-cell prolif, in remission
  • C82.4A - Follicular lymphoma grade IIIb, in remission
  • C86.50 - Angioimmunoblastic T-cell lymphoma not achieve remission
  • C86.10 - Hepatosplenic T-cell lymphoma not having achieved remission
  • C81.2A - Mixed cellularity Hodgkin lymphoma, in remission
  • C86.20 - Enteropathy-type (intestinal) T-cell lymphoma not remission
  • C83.390 - Primary central nervous system lymphoma
  • C84.ZA - Other mature T/NK-cell lymphomas, in remission
  • C86.01 - Extranodal NK/T-cell lymphoma, nasal type, in remission
  • C88.21 - Heavy chain disease, in remission
  • C85.9A - Non-Hodgkin lymphoma, unspecified, in remission
  • C81.3A - Lymphocyte depleted Hodgkin lymphoma, in remission
  • C86.11 - Hepatosplenic T-cell lymphoma, in remission
  • C86.60 - Primary cutaneous CD30-positive T-cell prolif not remission
  • C83.1A - Mantle cell lymphoma, in remission
  • C83.8A - Other non-follicular lymphoma, in remission
  • C84.AA - Cutaneous T-cell lymphoma, unspecified, in remission
  • C86.41 - Blastic NK-cell lymphoma, in remission
  • C88.40 - Extrnod mrgnl B-cell lymph mucosa-assoc lym tiss not remis
  • C82.8A - Other types of follicular lymphoma, in remission
  • C83.398 - Diffuse large B-cell lymph of extrnod and solid organ sites
  • C84.4A - Peripheral T-cell lymphoma, NEC, in remission
  • C88.90 - Malignant immunoproliferative disease, unsp not remission
  • C83.7A - Burkitt lymphoma, in remission
  • C86.30 - Subcutaneous panniculitis-like T-cell lymphoma not remission
  • C81.1A - Nodular sclerosis Hodgkin lymphoma, in remission
  • C88.30 - Immunoproliferative small intestinal disease not remission
  • C81.0A - Nodular lymphocyte predom Hodgkin lymphoma, in remission
  • C82.2A - Follicular lymphoma grade III, unspecified, in remission
  • C82.6A - Cutaneous follicle center lymphoma, in remission
  • C88.41 - Extrnod mrgnl B-cell lymph mucosa-assoc lym tiss, in remis
  • C82.0A - Follicular lymphoma grade I, in remission
  • C83.3A - Diffuse large B-cell lymphoma, in remission
  • C85.8A - Other specified types of non-Hodgkin lymphoma, in remission
  • C83.5A - Lymphoblastic (diffuse) lymphoma, in remission
  • C86.51 - Angioimmunoblastic T-cell lymphoma, in remission
  • C88.01 - Waldenstrom macroglobulinemia, in remission
  • C84.0A - Mycosis fungoides, in remission
  • C82.9A - Follicular lymphoma, unspecified, in remission
  • C84.6A - Anaplastic large cell lymphoma, ALK-positive, in remission
  • C84.9A - Mature T/NK-cell lymphomas, unspecified, in remission
  • C88.20 - Heavy chain disease not having achieved remission
  • C82.3A - Follicular lymphoma grade IIIa, in remission
  • C88.81 - Other malignant immunoproliferative diseases, in remission
  • C88.91 - Malignant immunoproliferative disease, unsp, in remission
  • C81.4A - Lymphocyte-rich Hodgkin lymphoma, in remission
  • C81.7A - Other Hodgkin lymphoma, in remission
  • C88.31 - Immunoproliferative small intestinal disease, in remission
  • C88.80 - Other malignant immunoproliferative diseases not remission
  • C84.7B - Anaplastic large cell lymphoma, ALK-negative, in remission
  • C85.1A - Unspecified B-cell lymphoma, in remission
  • C86.31 - Subcutaneous panniculitis-like T-cell lymphoma, in remission
  • C86.40 - Blastic NK-cell lymphoma not having achieved remission
  • C82.5A - Diffuse follicle center lymphoma, in remission
  • C83.0A - Small cell B-cell lymphoma, in remission
  • C86.00 - Extranodal NK/T-cell lymphoma, nasal type not remission
  • C81.9A - Hodgkin lymphoma, unspecified, in remission

Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)

Chapter 4: Endocrine, nutritional and metabolic diseases (E00–E89)

  • E34.01 - Carcinoid heart syndrome
  • E66.811 - Obesity, class 1
  • E66.812 - Obesity, class 2
  • E34.00 - Carcinoid syndrome, unspecified
  • E88.82 - Obesity due to disruption of MC4R pathway
  • E74.820 - SLC13A5 Citrate Transporter Disorder
  • E10.A0 - Type 1 diabetes mellitus, presymptomatic, unspecified
  • E34.09 - Other carcinoid syndrome
  • E10.A2 - Type 1 diabetes mellitus, presymptomatic, Stage 2
  • E16.A1 - Hypoglycemia level 1
  • E16.A2 - Hypoglycemia level 2
  • E16.A3 - Hypoglycemia level 3
  • E66.89 - Other obesity not elsewhere classified
  • E10.A1 - Type 1 diabetes mellitus, presymptomatic, Stage 1
  • E66.813 - Obesity, class 3
  • E74.829 - Other disorders of citrate metabolism

Chapter 5: Mental and behavioural disorders (F01–F99)

  • F50.812 - Binge eating disorder, severe
  • F50.21 - Bulimia nervosa, mild
  • F50.810 - Binge eating disorder, mild
  • F50.84 - Rumination disorder in adults
  • F50.020 - Anorexia nervosa, binge eating/purging type, mild
  • F50.22 - Bulimia nervosa, moderate
  • F50.813 - Binge eating disorder, extreme
  • F50.24 - Bulimia nervosa, extreme
  • F50.819 - Binge eating disorder, unspecified
  • F50.022 - Anorexia nervosa, binge eating/purging type, severe
  • F50.811 - Binge eating disorder, moderate
  • F50.011 - Anorexia nervosa, restricting type, moderate
  • F50.019 - Anorexia nervosa, restricting type, unspecified
  • F50.25 - Bulimia nervosa, in remission
  • F50.814 - Binge eating disorder, in remission
  • F50.20 - Bulimia nervosa, unspecified
  • F50.029 - Anorexia nervosa, binge eating/purging type, unspecified
  • F50.012 - Anorexia nervosa, restricting type, severe
  • F50.014 - Anorexia nervosa, restricting type, in remission
  • F50.024 - Anorexia nervosa, binge eating/purging type, in remission
  • F50.010 - Anorexia nervosa, restricting type, mild
  • F50.021 - Anorexia nervosa, binge eating/purging type, moderate
  • F50.23 - Bulimia nervosa, severe
  • F50.83 - Pica in adults
  • F50.013 - Anorexia nervosa, restricting type, extreme
  • F50.023 - Anorexia nervosa, binge eating/purging type, extreme

Chapter 6: Diseases of the nervous system (G00–G99)

  • G40.844 - KCNQ2-related epilepsy, intractable, without stat epi
  • G40.842 - KCNQ2-related epilepsy, not intractable, without stat epi
  • G93.45 - Developmental and epileptic encephalopathy
  • G90.81 - Serotonin syndrome
  • G90.89 - Other disorders of autonomic nervous system
  • G40.841 - KCNQ2-related epilepsy, not intractable, with stat epi
  • G40.843 - KCNQ2-related epilepsy, intractable, with status epilepticus

Chapter 9: Diseases of the circulatory system (I00–I99)

  • I26.04 - Fat embolism of pulmonary artery with acute cor pulmonale
  • I26.03 - Cement embolism of pulmonary artery with acute cor pulmonale
  • I26.96 - Fat embolism of pulmonary artery without acute cor pulmonale
  • I26.95 - Cement embolism of pulm artery without acute cor pulmonale

Chapter 10: Diseases of the respiratory system (J00–J99)

  • J34.829 - Nasal valve collapse, unspecified

  • J34.820 - Internal nasal valve collapse

  • J34.821 - External nasal valve collapse

Chapter 11: Diseases of the digestive system (K00–K95)

  • K60.523 - Anorectal fistula, complex, recurrent
  • K60.412 - Rectal fistula, simple, persistent
  • K60.50 - Anorectal fistula, unspecified
  • K60.522 - Anorectal fistula, complex, persistent
  • K60.429 - Rectal fistula, complex, unspecified
  • K60.40 - Rectal fistula, unspecified
  • K60.422 - Rectal fistula, complex, persistent
  • K60.413 - Rectal fistula, simple, recurrent
  • K60.313 - Anal fistula, simple, recurrent
  • K60.30 - Anal fistula, unspecified
  • K60.321 - Anal fistula, complex, initial
  • K60.411 - Rectal fistula, simple, initial
  • K60.423 - Rectal fistula, complex, recurrent
  • K60.529 - Anorectal fistula, complex, unspecified
  • K60.312 - Anal fistula, simple, persistent
  • K60.322 - Anal fistula, complex, persistent
  • K60.311 - Anal fistula, simple, initial
  • K60.421 - Rectal fistula, complex, initial
  • K60.521 - Anorectal fistula, complex, initial
  • K60.513 - Anorectal fistula, simple, recurrent
  • K60.323 - Anal fistula, complex, recurrent
  • K60.419 - Rectal fistula, simple, unspecified
  • K60.329 - Anal fistula, complex, unspecified
  • K60.319 - Anal fistula, simple, unspecified
  • K60.512 - Anorectal fistula, simple, persistent
  • K60.519 - Anorectal fistula, simple, unspecified
  • K60.511 - Anorectal fistula, simple, initial

Chapter 12: Diseases of the skin and subcutaneous tissue (L00–L99)

  • L66.19 - Other lichen planopilaris
  • L66.10 - Lichen planopilaris, unspecified
  • L66.81 - Central centrifugal cicatricial alopecia
  • L29.81 - Cholestatic pruritus
  • L66.12 - Frontal fibrosing alopecia
  • L29.89 - Other pruritus
  • L66.11 - Classic lichen planopilaris
  • L66.89 - Other cicatricial alopecia

Chapter 13: Diseases of the musculoskeletal system and connective tissue (M00–M99)

  • M51.371 - Oth intvrt disc degen, lumbosacr rgn w low extrm pain only
  • M62.85 - Dysfunction of the multifidus muscles, lumbar region
  • M65.911 - Unspecified synovitis and tenosynovitis, right shoulder
  • M51.379 - Oth intvrt disc degen, lumbosacr w/o lum bck or lw extrm pn
  • M65.942 - Unspecified synovitis and tenosynovitis, left hand
  • M65.99 - Unspecified synovitis and tenosynovitis, multiple sites
  • M51.362 - Oth intvrt disc degen, lum rgn w discog bck & lw extrm pain
  • M65.90 - Unspecified synovitis and tenosynovitis, unspecified site
  • M65.951 - Unspecified synovitis and tenosynovitis, right thigh
  • M65.949 - Unspecified synovitis and tenosynovitis, unspecified hand
  • M65.961 - Unspecified synovitis and tenosynovitis, right lower leg
  • M51.369 - Oth intvrt disc degen, lum rgn w/o lum bck or lw extrm pain
  • M65.912 - Unspecified synovitis and tenosynovitis, left shoulder
  • M65.979 - Unspecified synovitis and tenosynovitis, unspecified ank/ft
  • M51.370 - Oth intvrt disc degen, lumbosacr rgn w discog bck pain only
  • M51.372 - Oth intvrt disc degen, lumbosacr w discog bck & lw extrm pn
  • M65.931 - Unspecified synovitis and tenosynovitis, right forearm
  • M65.932 - Unspecified synovitis and tenosynovitis, left forearm
  • M65.98 - Unspecified synovitis and tenosynovitis, other site
  • M51.360 - Other intvrt disc degen, lum rgn with discog back pain only
  • M65.922 - Unspecified synovitis and tenosynovitis, left upper arm
  • M65.969 - Unsp synovitis and tenosynovitis, unspecified lower leg
  • M65.939 - Unspecified synovitis and tenosynovitis, unspecified forearm
  • M65.952 - Unspecified synovitis and tenosynovitis, left thigh
  • M65.941 - Unspecified synovitis and tenosynovitis, right hand
  • M65.929 - Unsp synovitis and tenosynovitis, unspecified upper arm
  • M65.962 - Unspecified synovitis and tenosynovitis, left lower leg
  • M51.361 - Other intvrt disc degen, lum region with low extrm pain only
  • M65.919 - Unsp synovitis and tenosynovitis, unspecified shoulder
  • M65.921 - Unspecified synovitis and tenosynovitis, right upper arm
  • M65.971 - Unspecified synovitis and tenosynovitis, right ank/ft
  • M65.959 - Unspecified synovitis and tenosynovitis, unspecified thigh
  • M65.972 - Unspecified synovitis and tenosynovitis, left ankle and foot

Chapter 17: Congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)

  • Q23.88 - Other congenital malformations of aortic and mitral valves
  • Q87.86 - Kleefstra syndrome
  • Q23.81 - Bicuspid aortic valve
  • Q23.82 - Congenital mitral valve cleft leaflet

Chapter 18: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00–R99)

Chapter 19: Injury, poisoning and certain other consequences of external causes (S00–T88)

  • T45.AX3 - Poisoning by immune chkpt inhibtr/immunostim drugs, assault

  • T81.328 - Disrupt/dehisc of closure of oth internal op (surg) wound

  • T45.AX2 - Poisn by immune chkpt inhibtr/immunostim drugs, self-harm

  • T81.321 - Disrupt/dehisc of closr of int op (surg) wnd abd wl msl/fasc

  • T45.AX1 - Poisoning by immune chkpt inhibtr/immunostim drugs, acc

  • T45.AX4 - Poisoning by immune chkpt inhibtr/immunostim drugs, undet

  • T81.329 - Deep Disrupt/dehisc of operation wound, unspecified

  • T45.AX6 - Underdosing of immune checkpoint inhibtr/immunostim drugs

  • T81.320 - Disrupt/dehisc of GI tract anastomosis, repair, or closure

  • T45.AX5 - Adverse effect of immune checkpoint inhibtr/immunostim drugs

Chapter 21: Factors influencing health status and contact with health services (Z00–Z99)

  • Z17.31 - Human epidermal growth factor receptor 2 positive status
  • Z68.55 - Body mass index ped, 120% 95% for age to < 140% 95% for age
  • Z68.56 - Body mass index ped, > or equal to 140% of the 95% for age
  • Z17.22 - Progesterone receptor negative status
  • Z15.2 - Genetic susceptibility to obesity
  • Z51.A - Encounter for sepsis aftercare
  • Z92.26 - Personal history of immune checkpoint inhibitor therapy
  • Z17.32 - Human epidermal growth factor receptor 2 negative status
  • Z59.71 - Insufficient health insurance coverage
  • Z15.1 - Genetic susceptibility to epi and neurodevelopmental disord
  • Z17.411 - Hormone recept pos w hmn epdrml grth fctr recept 2 neg stat
  • Z59.72 - Insufficient welfare support
  • Z67.A3 - Duffy b positive
  • Z17.420 - Hormone recept neg w hmn epdrml grth fctr recept 2 pos stat

  • Z86.010 - Personal history of colon polyps

  • Z17.421 - Hormone recept neg w hmn epdrml grth fctr recept 2 neg stat
  • Z67.A1 - Duffy null
  • Z83.72 - Family history of familial adenomatous polyposis
  • Z17.21 - Progesterone receptor positive status
  • Z67.A4 - Duffy a and b positive
  • Z67.A2 - Duffy a positive
  • Z17.410 - Hormone recept pos w hmn epdrml grth fctr recept 2 pos stat