ICD-10-CM Code E23.3

Hypothalamic dysfunction, not elsewhere classified

Version 2021 Billable Code

Valid for Submission

E23.3 is a billable code used to specify a medical diagnosis of hypothalamic dysfunction, not elsewhere classified. The code is valid for the fiscal year 2021 for the submission of HIPAA-covered transactions. The ICD-10-CM code E23.3 might also be used to specify conditions or terms like absent osmoregulation, central alveolar hypoventilation syndrome, childhood obesity, defective osmoregulation, defective osmoregulation, endocrine axis dysfunction, etc

Short Description:Hypothalamic dysfunction, not elsewhere classified
Long Description:Hypothalamic dysfunction, not elsewhere classified

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code E23.3:

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Prader-Willi syndrome Q87.11
  • Russell-Silver syndrome Q87.19

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code E23.3 are found in the index:


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Absent osmoregulation
  • Central alveolar hypoventilation syndrome
  • Childhood obesity
  • Defective osmoregulation
  • Defective osmoregulation
  • Endocrine axis dysfunction
  • Endocrine menstrual disturbance
  • Exercise induced hypothalamic insufficiency
  • Hypothalamic amenorrhea
  • Hypothalamic disorder of appetite
  • Hypothalamic overactivity
  • Hypothalamic syndrome
  • Hypothalamic-pituitary-gonadal axis dysfunction
  • Late-onset central hypoventilation co-occurrent and due to hypothalamic dysfunction
  • Loss of hypothalamic inhibition
  • Obesity by age of onset
  • Osmoregulation defect - absent thirst
  • Primary hypothalamic insufficiency
  • Rapid-onset childhood obesity, hypothalamic dysfunction, hypoventilation, autonomic dysregulation syndrome
  • Secondary hypothalamic insufficiency

Diagnostic Related Groups

The ICD-10 code E23.3 is grouped in the following groups for version MS-DRG V38.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2020 through 09/30/2021.


Convert E23.3 to ICD-9

  • 253.9 - Pituitary disorder NOS (Approximate Flag)

Code Classification

  • Endocrine, nutritional and metabolic diseases (E00–E90)
    • Disorders of other endocrine glands (E20-E35)
      • Hypofunction and other disorders of the pituitary gland (E23)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients

Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

With pituitary disorders, you often have too much or too little of one of your hormones. Injuries can cause pituitary disorders, but the most common cause is a pituitary tumor.

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