2026 ICD-10-CM Diagnosis Code R77Other abnormalities of plasma proteins

ICD-10-CM Codes›R00–R99›R70-R79›R77

ICD-10-CM R77
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R77 is a non-billable ICD-10-CM category code for other abnormalities of plasma proteins, so it cannot be submitted on claims. Use a more specific code from this category instead, such as R77.0, R77.1, R77.2, and R77.8. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established.

Code Identity

ICD-10-CM Code
R77
Billable Status
No — Non-Billable Category
Code Describes
Other abnormalities of plasma proteins
Chapter
R70-R79
Abnormal findings on examination of blood, without diagnosis

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR70-R79Abnormal findings on examination of blood, without diagnosis
CategoryR77Other abnormalities of plasma proteins
This CodeR77Other abnormalities of plasma proteins

Specific Coding for Other abnormalities of plasma proteinsOverview

Non-specific codes like R77 require more characters. Use one of these billable codes instead:

  • Use R77.0 for Abnormality of albumin

  • Use R77.1 for Abnormality of globulin

  • Use R77.2 for Abnormality of alphafetoprotein

  • Use R77.8 for Other specified abnormalities of plasma proteins

  • Use R77.9 for Abnormality of plasma protein, unspecified

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Type 1 Excludes

  • disorders of plasma-protein metabolism E88.0

Patient EducationClinical

Blood

Your blood is made up of liquid and solids. The liquid part, called plasma, is made of water, salts, and protein. Over half of your blood is plasma. The solid part of your blood contains red blood cells, white blood cells, and platelets.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R77Overview

Is R77 (Other abnormalities of plasma proteins) a billable code?

No. This is a category header that groups the codes for other abnormalities of plasma proteins, and headers cannot be submitted on claims. Claims for other abnormalities of plasma proteins need a more specific code from this category, such as R77.0, R77.1, and R77.2.

Can R77 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the other abnormalities of plasma proteins is established, that condition takes the principal position instead.