ICD-10-CM Code E53.8

Deficiency of other specified B group vitamins

Version 2020 Billable Code

Valid for Submission

E53.8 is a billable code used to specify a medical diagnosis of deficiency of other specified b group vitamins. The code is valid for the year 2020 for the submission of HIPAA-covered transactions. The ICD-10-CM code E53.8 might also be used to specify conditions or terms like biotin deficiency, biotin deficiency disease, cerebral degeneration due to vitamin b12 deficiency, choline deficiency, cobalamin deficiency, dermatosis associated with biotin deficiency, etc

Short Description:Deficiency of other specified B group vitamins
Long Description:Deficiency of other specified B group vitamins

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code E53.8:

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Biotin deficiency
  • Cyanocobalamin deficiency
  • Folate deficiency
  • Folic acid deficiency
  • Pantothenic acid deficiency
  • Vitamin B12 deficiency

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • folate deficiency anemia D52
  • vitamin B12 deficiency anemia D51

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code E53.8 are found in the index:


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Biotin deficiency
  • Biotin deficiency disease
  • Cerebral degeneration due to vitamin B12 deficiency
  • Choline deficiency
  • Cobalamin deficiency
  • Dermatosis associated with biotin deficiency
  • Disorder of biotin
  • Disorder of vitamin B12
  • Encephalopathy due to nutritional deficiency
  • Encephalopathy due to nutritional deficiency
  • Encephalopathy due to vitamin deficiency
  • Folate deficiency glossitis
  • Folic acid deficiency
  • Folic acid deficiency
  • Inadequate biotin intake
  • Inadequate dietary intake of biotin
  • Inadequate dietary intake of folate
  • Inadequate dietary intake of pantothenic acid
  • Inadequate pantothenic acid intake
  • Inadequate vitamin B12 intake
  • Myelopathy due to nutritional deficiency
  • Neuropathy due to folic acid deficiency
  • Neuropathy due to vitamin B deficiency
  • Neuropathy due to vitamin B deficiency
  • Neuropathy due to vitamin B deficiency
  • Neuropathy due to vitamin B12 deficiency
  • Neuropathy due to vitamin B6 deficiency
  • Optic neuropathy due to folate deficiency
  • Pantothenic acid deficiency
  • Polyneuropathy due to vitamin B deficiency
  • Subacute combined degeneration of spinal cord
  • Vitamin B12 deficiency
  • White matter disorder due to vitamin B12 deficiency

Diagnostic Related Groups

The ICD-10 code E53.8 is grouped in the following groups for version MS-DRG V37.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2019 through 09/30/2020.


Convert E53.8 to ICD-9

  • 266.2 - B-complex defic NEC (Approximate Flag)

Code Classification

  • Endocrine, nutritional and metabolic diseases (E00–E90)
    • Other nutritional deficiencies (E50-E64)
      • Deficiency of other B group vitamins (E53)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients

B Vitamins

The B vitamins are

  • B1 (thiamine)
  • B2 (riboflavin)
  • B3 (niacin)
  • B5 (pantothenic acid)
  • B6
  • B7 (biotin)
  • B12
  • Folic acid

These vitamins help the process your body uses to get or make energy from the food you eat. They also help form red blood cells. You can get B vitamins from proteins such as fish, poultry, meat, eggs, and dairy products. Leafy green vegetables, beans, and peas also have B vitamins. Many cereals and some breads have added B vitamins.

Not getting enough of certain B vitamins can cause diseases. A lack of B12 or B6 can cause anemia.

[Learn More]


Food provides the energy and nutrients you need to be healthy. If you don't get enough nutrients -- including proteins, carbohydrates, fats, vitamins, and minerals - you may suffer from malnutrition.

Causes of malnutrition include:

  • Lack of specific nutrients in your diet. Even the lack of one vitamin can lead to malnutrition.
  • An unbalanced diet
  • Certain medical problems, such as malabsorption syndromes and cancers

Symptoms may include fatigue, dizziness, and weight loss. Or, you may have no symptoms. To diagnose the cause of the problem, your doctor may do blood tests and a nutritional assessment. Treatment may include replacing the missing nutrients and treating the underlying cause.

[Learn More]