ICD-10-CM Instructional Notes · Guidelines Section I.A.13 · FY 2027 810 Notes

ICD-10-CM Code First Notes ICD-10-CM

A Code First note means the underlying condition named in the note is sequenced before this code. The FY 2027 Tabular List has 810 Code First Notes; 600 of them name other codes, with 736 references to 429 distinct codes, categories and ranges. Pick a chapter below to see every note in it, by the code that carries the note or by the code it names.

✓ From the official FY 2027 ICD-10-CM Tabular ListDefinitions follow the Official Guidelines, Section I.A
810
Code First Notes
600
Notes Naming Codes
736
Code References
429
Codes Referenced
What the Official Guidelines say about Code First Notes Section I.A.13

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. ICD-10-CM requires the underlying condition to be sequenced first, if applicable, followed by the manifestation. Wherever such a combination exists, there is a "code first" note at the manifestation code and a "use additional code" note at the etiology code. Manifestation codes titled "in diseases classified elsewhere" are never permitted as the first-listed or principal diagnosis. "Code first" notes are also used as sequencing rules for certain codes that are not part of an etiology/manifestation combination (Section I.B.7).

Read the ICD-10-CM Official Guidelines →

ICD-10-CM

Code First Notes by Chapter 22 chapters

ChapterTitleReferences to Its CodesCodes NamedReferences in Its Notes
A00-B99Chapter 1: Certain infectious and parasitic diseases814727
C00-D49Chapter 2: Neoplasms45203
D50-D89Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism272030
E00-E89Chapter 4: Endocrine, nutritional and metabolic diseases1026414
F01-F99Chapter 5: Mental and behavioural disorders10945
G00-G99Chapter 6: Diseases of the nervous system231567
H00-H59Chapter 7: Diseases of the eye and adnexa1128
H60-H95Chapter 8: Diseases of the ear and mastoid process9816
I00-I99Chapter 9: Diseases of the circulatory system725786
J00-J99Chapter 10: Diseases of the respiratory system352075
K00-K95Chapter 11: Diseases of the digestive system211634
L00-L99Chapter 12: Diseases of the skin and subcutaneous tissue131141
M00-M99Chapter 13: Diseases of the musculoskeletal system and connective tissue533087
N00-N99Chapter 14: Diseases of the genitourinary system11639
O00-O9AChapter 15: Pregnancy, childbirth and the puerperium51285
P00-P96Chapter 16: Certain conditions originating in the perinatal period976
Q00-QA1Chapter 17: Congenital malformations, deformations and chromosomal abnormalities551
R00-R99Chapter 18: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified4336
S00-T88Chapter 19: Injury, poisoning and certain other consequences of external causes1545554
V00-Y99Chapter 20: External causes of morbidity and mortality446
Z00-Z99Chapter 21: Factors influencing health status and contact with health services3230
U00-U49Chapter 22: Codes for Special Purposes316

“References to its codes” counts notes anywhere in the Tabular List that name a code in the chapter; “references in its notes” counts the codes named by notes printed in the chapter. Each chapter page shows both lists.

Questions About Code First Notes

What does a Code First note mean?

A Code First note means the underlying condition named in the note is sequenced before the code that carries the note. Under the etiology/manifestation convention, a “code first” note appears at the manifestation code and a “use additional code” note at the etiology code (Section I.A.13). The FY 2027 Tabular List has 810 of them; 600 name other codes, with 736 references to 429 distinct codes, categories and ranges.

Can a code with a Code First note be the principal diagnosis?

Not when it is a manifestation code. Codes titled “in diseases classified elsewhere” are never permitted as the first-listed or principal diagnosis; they must follow the underlying condition. The etiology and manifestation page lists them all.

Is Code First used only for manifestation codes?

No. “Code first” and “use additional code” notes are also used as sequencing rules for certain codes that are not part of an etiology/manifestation combination (Section I.A.13 and Section I.B.7, multiple coding for a single condition).

Official Sources & Methodology

Every note on these pages is loaded verbatim from the FY 2027 ICD-10-CM Tabular List. Code references inside the notes are matched against the FY 2027 code set, so every link opens a valid code; scope counts (“applies to N codes”) count the billable codes under the note’s chapter, block or category.

ICD List is not affiliated with CMS or NCHS. These pages are a coding reference; the Tabular List and the Official Guidelines remain the authority.

Related References

Source: FY 2027 ICD-10-CM Tabular List (CMS and NCHS) and the ICD-10-CM Official Guidelines for Coding and Reporting FY 2027, Section I.A. ICD List is not affiliated with CMS or NCHS.