2026 ICD-10-CM Diagnosis Code D55Anemia due to enzyme disorders

ICD-10-CM Codes›D50–D89›D55-D59›D55

ICD-10-CM D55
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D55 is a non-billable ICD-10-CM category code for anemia due to enzyme disorders, so it cannot be submitted on claims. Use a more specific code from this category instead, such as D55.0, D55.1, D55.21, and D55.29.

Code Identity

ICD-10-CM Code
D55
Billable Status
No — Non-Billable Category
Code Describes
Anemia due to enzyme disorders
Chapter
D55-D59
Hemolytic anemias

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD55-D59Hemolytic anemias
CategoryD55Anemia due to enzyme disorders
This CodeD55Anemia due to enzyme disorders

Specific Coding for Anemia due to enzyme disordersOverview

Non-specific codes like D55 require more characters. Use one of these billable codes instead:

  • Use D55.0 for Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency

  • Use D55.1 for Anemia due to other disorders of glutathione metabolism

  • D55.2 for Anemia due to disorders of glycolytic enzymes

  • Use D55.21 for Anemia due to pyruvate kinase deficiency

  • Use D55.29 for Anemia due to other disorders of glycolytic enzymes

  • Use D55.3 for Anemia due to disorders of nucleotide metabolism

  • Use D55.8 for Other anemias due to enzyme disorders

  • Use D55.9 for Anemia due to enzyme disorder, unspecified

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Type 1 Excludes

  • drug-induced enzyme deficiency anemia D59.2

Patient EducationClinical

Anemia

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D55Overview

Is D55 (Anemia due to enzyme disorders) a billable code?

No. This is a category header that groups the codes for anemia due to enzyme disorders, and headers cannot be submitted on claims. Claims for anemia due to enzyme disorders need a more specific code from this category, such as D55.0, D55.1, and D55.21.