2027 ICD-10-CM Diagnosis Code D55Anemia due to enzyme disorders

ICD-10-CM Codes›D50–D89›D55-D59›D55

ICD-10-CM D55
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

D55 is a non-billable ICD-10-CM category code for anemia due to enzyme disorders, so it cannot be submitted on claims. Use a more specific code from this category instead, such as D55.0, D55.1, D55.21, and D55.29.

Code Identity

ICD-10-CM Code
D55
Billable Status
No — Non-Billable Category
Code Describes
Anemia due to enzyme disorders
Short Description
Anemia due to enzyme disorders
Same as the full description in the CMS dataset.
Chapter
D55-D59
Hemolytic anemias

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD55-D59Hemolytic anemias
CategoryD55Anemia due to enzyme disorders
This CodeD55Anemia due to enzyme disorders

Specific Coding for Anemia due to enzyme disordersOverview

Non-specific codes like D55 require more characters. Use one of these billable codes instead:

  • Use D55.0 for Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency

  • Use D55.1 for Anemia due to other disorders of glutathione metabolism

  • D55.2 for Anemia due to disorders of glycolytic enzymes

  • Use D55.21 for Anemia due to pyruvate kinase deficiency

  • Use D55.29 for Anemia due to other disorders of glycolytic enzymes

  • Use D55.3 for Anemia due to disorders of nucleotide metabolism

  • Use D55.8 for Other anemias due to enzyme disorders

  • Use D55.9 for Anemia due to enzyme disorder, unspecified

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to D55: its own notes plus those printed at Chapter 3. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

  • drug-induced enzyme deficiency anemia (D59.2)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Chapter 3 (D50-D89) Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism applies to 324 codes
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name D55, its category, or a range that includes it.

Excludes1 3

These codes carry an Excludes1 note naming D55: they are not reported together with it, unless the two conditions are unrelated.

  • Block E70-E88 Metabolic disorders
    hemolytic anemias attributable to enzyme disorders (D55.-)
  • E74.4 Disorders of pyruvate metabolism and gluconeogenesis
    disorders of pyruvate metabolism and gluconeogenesis with anemia (D55.-)
  • Block P50-P61 Hemorrhagic and hematological disorders of newborn
    hereditary hemolytic anemias (D55-D58)

Patient EducationClinical

Anemia

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About D55Overview

What is the ICD-10 code for anemia due to enzyme disorders?

D55 is the ICD-10-CM category for anemia due to enzyme disorders, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is D55 (Anemia due to enzyme disorders) a billable code?

No. This is a category header that groups the codes for anemia due to enzyme disorders, and headers cannot be submitted on claims. Claims for anemia due to enzyme disorders need a more specific code from this category, such as D55.0, D55.1, and D55.21.

Can D55 be reported with D59.2?

Not as a rule. The Excludes1 note on D55 lists "drug-induced enzyme deficiency anemia (D59.2)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).