2025 ICD-10-CM Diagnosis Code D61.03

Clinical Information

• BRCA2 Protein

  a large, nuclear protein, encoded by the brca2 gene (gene, brca2). mutations in this gene predispose humans to breast and ovarian cancer. the brca2 protein is an essential component of dna repair pathways, suppressing the formation of gross chromosomal rearrangements. (from genes dev. 2000;14(11):1400-6)

• Fanconi Anemia

  congenital disorder affecting all bone marrow elements, resulting in anemia; leukopenia; and thrombopenia, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. spontaneous chromosome breakage is a feature of this disease along with predisposition to leukemia. there are at least 7 complementation groups in fanconi anemia: fanca, fancb, fancc, fancd1, fancd2, fance, fancf, fancg, and fancl. (from online mendelian inheritance in man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, august 20, 2004)

• Fanconi Anemia Complementation Group A Protein

  a fanconi anemia complementation group protein that is the most commonly mutated protein in fanconi anemia. it undergoes phosphorylation by protein kinase b and forms a complex with fancc protein in the cell nucleus.

• Fanconi Anemia Complementation Group C Protein

  a fanconi anemia complementation group protein that regulates the activities of cytochrome p450 reductase and glutathione s-transferase. it is found predominately in the cytoplasm, but moves to the cell nucleus in response to fance protein.

• Fanconi Anemia Complementation Group D2 Protein

  a fanconi anemia complementation group protein that undergoes mono-ubiquitination by fancl protein in response to dna damage. also, in response to ionizing radiation it can undergo phosphorylation by ataxia telangiectasia mutated protein. modified fancd2 interacts with brca2 protein in a stable complex with chromatin, and it is involved in dna repair by homologous recombination.

• Fanconi Anemia Complementation Group E Protein

  a fanconi anemia complementation group protein that interacts with fancc protein and fancd2 protein. it promotes the accumulation of fancc protein in the cell nucleus.

• Fanconi Anemia Complementation Group F Protein

  a fanconi anemia complementation group protein. it is an essential component of a nuclear core complex that protects the genome against chromosomal instability. it interacts directly with fancg protein and helps stabilize a complex with fanca protein and fancc protein.

• Fanconi Anemia Complementation Group G Protein

  a fanconi anemia complementation group protein that undergoes phosphorylation by cdc2 protein kinase during mitosis. it forms a complex with other fanconi anemia proteins and helps protect cells from dna damage by genotoxic agents.

• Fanconi Anemia Complementation Group L Protein

  an e3 ubiquitin ligase that plays a key role in the dna damage response pathway of fanconi anemia proteins. it is associated with mono-ubiquitination of fancd2 protein and the redistribution of fancd2 to nuclear foci containing brca1 protein.

• Fanconi Anemia Complementation Group N Protein

  a fanconi anemia complementation group protein that contains an n-terminal dna-binding region and seven, c-terminal, wd repeats. it is an essential factor in homologous recombination dna repair through its interactions with brca2 protein; rad51 recombinase; and brca1 protein. it functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. mutations in the palb2 gene are associated with fanconi anemia complementation group n; type 3 pancreatic neoplasms; and susceptibility to breast cancer.

• Fanconi Anemia Complementation Group Proteins

  a diverse group of proteins whose genetic mutations have been associated with the chromosomal instability syndrome fanconi anemia. many of these proteins play important roles in protecting cells against oxidative stress.

New 2025 ICD-10-CM Code

D61.03 is new to ICD-10-CM code set for the FY 2025, effective October 1, 2024. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2024. This is a new and revised code for the FY 2025 (October 1, 2024 - September 30, 2025).

D61.03 is grouped with Diagnostic Related Groups - MS-DRG Mapping

Diagnosis-Related Groups (DRGs) are used to classify hospital cases for billing and healthcare management. They help standardize how hospitals and other providers are reimbursed for inpatient care. Patients are grouped based on their principal diagnosis into broader categories called Major Diagnostic Categories (MDCs).

Once assigned to a DRG, the hospital receives a set payment for the patient’s care, regardless of the actual services provided. This fixed rate is intended to cover the typical cost of treating patients within that group. The payment amount depends on the DRG's relative weight, which reflects the expected complexity and cost of care based on the severity of the patient’s condition.

Diagnostic related groups encourage healthcare providers to focus on quality and efficiency in patient care while managing costs effectively. The diagnosis code is present in the following groups for version MS-DRG V42.0 applicable from 10/01/2024 through 09/30/2025.

Replacement Code

D6103 replaces the following previously assigned ICD-10-CM code(s):

• D61.09 - Other constitutional aplastic anemia

Code History