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  6. 2025 ICD-10-CM Code E72
Version 2025
Non-Billable Code

2025 ICD-10-CM Diagnosis Code E72

Other disorders of amino-acid metabolism

ICD-10-CM Code:
E72
ICD-10 Code for:
Other disorders of amino-acid metabolism
Is Billable?
Not Valid for Submission
Code Navigator:

E72 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of other disorders of amino-acid metabolism. The code is not specific and is NOT valid for the year 2025 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding Applicable to Other disorders of amino-acid metabolism

Non-specific codes like E72 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for other disorders of amino-acid metabolism:

  • E72.0 for Disorders of amino-acid transport - NON-BILLABLE CODE

  • Use E72.00 for Disorders of amino-acid transport, unspecified - BILLABLE CODE

  • Use E72.01 for Cystinuria - BILLABLE CODE

  • Use E72.02 for Hartnup's disease - BILLABLE CODE

  • Use E72.03 for Lowe's syndrome - BILLABLE CODE

  • Use E72.04 for Cystinosis - BILLABLE CODE

  • Use E72.09 for Other disorders of amino-acid transport - BILLABLE CODE

  • E72.1 for Disorders of sulfur-bearing amino-acid metabolism - NON-BILLABLE CODE

  • Use E72.10 for Disorders of sulfur-bearing amino-acid metabolism, unspecified - BILLABLE CODE

  • Use E72.11 for Homocystinuria - BILLABLE CODE

  • Use E72.12 for Methylenetetrahydrofolate reductase deficiency - BILLABLE CODE

  • Use E72.19 for Other disorders of sulfur-bearing amino-acid metabolism - BILLABLE CODE

  • E72.2 for Disorders of urea cycle metabolism - NON-BILLABLE CODE

  • Use E72.20 for Disorder of urea cycle metabolism, unspecified - BILLABLE CODE

  • Use E72.21 for Argininemia - BILLABLE CODE

  • Use E72.22 for Arginosuccinic aciduria - BILLABLE CODE

  • Use E72.23 for Citrullinemia - BILLABLE CODE

  • Use E72.29 for Other disorders of urea cycle metabolism - BILLABLE CODE

  • Use E72.3 for Disorders of lysine and hydroxylysine metabolism - BILLABLE CODE

  • Use E72.4 for Disorders of ornithine metabolism - BILLABLE CODE

  • E72.5 for Disorders of glycine metabolism - NON-BILLABLE CODE

  • Use E72.50 for Disorder of glycine metabolism, unspecified - BILLABLE CODE

  • Use E72.51 for Non-ketotic hyperglycinemia - BILLABLE CODE

  • Use E72.52 for Trimethylaminuria - BILLABLE CODE

  • Use E72.53 for Primary hyperoxaluria - BILLABLE CODE

  • Use E72.59 for Other disorders of glycine metabolism - BILLABLE CODE

  • E72.8 for Other specified disorders of amino-acid metabolism - NON-BILLABLE CODE

  • Use E72.81 for Disorders of gamma aminobutyric acid metabolism - BILLABLE CODE

  • Use E72.89 for Other specified disorders of amino-acid metabolism - BILLABLE CODE

  • Use E72.9 for Disorder of amino-acid metabolism, unspecified - BILLABLE CODE

Code Classification

  • Endocrine, nutritional and metabolic diseases
    (E00–E89)
    • Metabolic disorders
      (E70-E88)
      • Other disorders of amino-acid metabolism
        (E72)

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • disorders of:
  • aromatic amino-acid metabolism E70
  • branched-chain amino-acid metabolism E71.0 E71.2
  • fatty-acid metabolism E71.3
  • purine and pyrimidine metabolism E79
  • gout M1A M10

Patient Education


Amino Acid Metabolism Disorders

Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Your digestive system breaks the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body. If you have a metabolic disorder, something goes wrong with this process.

One group of these disorders is amino acid metabolism disorders. They include phenylketonuria (PKU) and maple syrup urine disease. Amino acids are "building blocks" that join together to form proteins. If you have one of these disorders, your body may have trouble breaking down certain amino acids. Or there may be a problem getting the amino acids into your cells. These problems cause a buildup of harmful substances in your body. That can lead to serious, sometimes life-threatening, health problems.

These disorders are usually inherited. A baby who is born with one may not have any symptoms right away. Because the disorders can be so serious, early diagnosis and treatment are critical. Newborn babies get screened for many of them, using blood tests.

Treatments may include special diets, medicines, and supplements. Some babies may also need additional treatments if there are complications.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.