2027 ICD-10-CM Diagnosis Code E72Other disorders of amino-acid metabolism

ICD-10-CM Codes›E00–E89›E70-E88›E72

ICD-10-CM E72
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E72 is a non-billable ICD-10-CM category code for other disorders of amino-acid metabolism, so it cannot be submitted on claims. Use a more specific code from this category instead, such as E72.00, E72.01, E72.02, and E72.03.

Code Identity

ICD-10-CM Code
E72
Billable Status
No — Non-Billable Category
Code Describes
Other disorders of amino-acid metabolism
Short Description
Other disorders of amino-acid metabolism
Same as the full description in the CMS dataset.
Chapter
E70-E88
Metabolic disorders

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE72Other disorders of amino-acid metabolism
This CodeE72Other disorders of amino-acid metabolism

Specific Coding for Other disorders of amino-acid metabolismOverview

Non-specific codes like E72 require more characters. Use one of these billable codes instead:

  • E72.0 for Disorders of amino-acid transport

  • Use E72.00 for Disorders of amino-acid transport, unspecified

  • Use E72.01 for Cystinuria

  • Use E72.02 for Hartnup's disease

  • Use E72.03 for Lowe's syndrome

  • Use E72.04 for Cystinosis

  • Use E72.09 for Other disorders of amino-acid transport

  • E72.1 for Disorders of sulfur-bearing amino-acid metabolism

  • Use E72.10 for Disorders of sulfur-bearing amino-acid metabolism, unspecified

  • Use E72.11 for Homocystinuria

  • Use E72.12 for Methylenetetrahydrofolate reductase deficiency

  • Use E72.19 for Other disorders of sulfur-bearing amino-acid metabolism

  • E72.2 for Disorders of urea cycle metabolism

  • Use E72.20 for Disorder of urea cycle metabolism, unspecified

  • Use E72.21 for Argininemia

  • Use E72.22 for Arginosuccinic aciduria

  • Use E72.23 for Citrullinemia

  • Use E72.29 for Other disorders of urea cycle metabolism

  • Use E72.3 for Disorders of lysine and hydroxylysine metabolism

  • Use E72.4 for Disorders of ornithine metabolism

  • E72.5 for Disorders of glycine metabolism

  • Use E72.50 for Disorder of glycine metabolism, unspecified

  • Use E72.51 for Non-ketotic hyperglycinemia

  • Use E72.52 for Trimethylaminuria

  • E72.53 for Primary hyperoxaluria

  • E72.54 for Secondary hyperoxaluria

  • Use E72.59 for Other disorders of glycine metabolism

  • E72.8 for Other specified disorders of amino-acid metabolism

  • Use E72.81 for Disorders of gamma aminobutyric acid metabolism

  • Use E72.89 for Other specified disorders of amino-acid metabolism

  • Use E72.9 for Disorder of amino-acid metabolism, unspecified

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E72: its own notes plus those printed at block E70-E88 and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

On E72 itself
  • disorders of:
  • aromatic amino-acid metabolism (E70.-)
  • branched-chain amino-acid metabolism (E71.0-E71.2)
  • fatty-acid metabolism (E71.3)
  • purine and pyrimidine metabolism (E79.-)
  • gout (M1A.-, M10.-)
From Block E70-E88 Metabolic disorders applies to 286 codes
  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block E70-E88 Metabolic disorders applies to 286 codes
  • Ehlers-Danlos syndromes (Q79.6-)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E72, its category, or a range that includes it.

Excludes1 3

These codes carry an Excludes1 note naming E72: they are not reported together with it, unless the two conditions are unrelated.

  • R79 Other abnormal findings of blood chemistry
    specific findings indicating disorder of amino-acid metabolism (E70-E72) names E70-E72, which includes this code
  • R79.83 Abnormal findings of blood amino-acid level
    disorders of amino-acid metabolism (E70-E72) names E70-E72, which includes this code
  • Block R80-R82 Abnormal findings on examination of urine, without diagnosis
    specific findings indicating disorder of amino-acid metabolism (E70-E72) names E70-E72, which includes this code

Patient EducationClinical

Amino Acid Metabolism Disorders

Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Your digestive system breaks the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E72Overview

What is the ICD-10 code for other disorders of amino-acid metabolism?

E72 is the ICD-10-CM category for other disorders of amino-acid metabolism, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is E72 (Other disorders of amino-acid metabolism) a billable code?

No. This is a category header that groups the codes for other disorders of amino-acid metabolism, and headers cannot be submitted on claims. Claims for other disorders of amino-acid metabolism need a more specific code from this category, such as E72.00, E72.01, and E72.02.

Can E72 be reported with a code from E70?

Not as a rule. The Excludes1 note on E72 lists "aromatic amino-acid metabolism (E70.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).