2021 ICD-10-CM Code E85


Version 2021

Not Valid for Submission

E85 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of amyloidosis. The code is not specific and is NOT valid for the year 2021 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Short Description:Amyloidosis
Long Description:Amyloidosis

Code Classification

Specific Coding for Amyloidosis

Non-specific codes like E85 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10 codes with a higher level of specificity when coding for amyloidosis:

  • BILLABLE CODE - Use E85.0 for Non-neuropathic heredofamilial amyloidosis
  • BILLABLE CODE - Use E85.1 for Neuropathic heredofamilial amyloidosis
  • BILLABLE CODE - Use E85.2 for Heredofamilial amyloidosis, unspecified
  • BILLABLE CODE - Use E85.3 for Secondary systemic amyloidosis
  • BILLABLE CODE - Use E85.4 for Organ-limited amyloidosis
  • NON-BILLABLE CODE - E85.8 for Other amyloidosis
  • BILLABLE CODE - Use E85.81 for Light chain (AL) amyloidosis
  • BILLABLE CODE - Use E85.82 for Wild-type transthyretin-related (ATTR) amyloidosis
  • BILLABLE CODE - Use E85.89 for Other amyloidosis
  • BILLABLE CODE - Use E85.9 for Amyloidosis, unspecified

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code E85:

Type 2 Excludes

Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.

Clinical Information

Information for Patients


Amyloidosis occurs when abnormal proteins called amyloids build up and form deposits. The deposits can collect in organs such as the kidney and heart. This can cause the organs to become stiff and unable to work the way they should.

There are three main types of amyloidosis:

Symptoms can vary, depending upon which organs are affected. Treatment depends on the type of amyloidosis you have. The goal is to help with symptoms and limit the production of proteins. If another disease is the cause, it needs to be treated.

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Code History

  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016 (First year ICD-10-CM implemented into the HIPAA code set)