2026 ICD-10-CM Diagnosis Code E85Amyloidosis
E85 is a non-billable ICD-10-CM category code for amyloidosis, so it cannot be submitted on claims. Use a more specific code from this category instead, such as E85.0, E85.1, E85.2, and E85.3.
Code Identity
Code Classification
Specific Coding for AmyloidosisOverview
Non-specific codes like E85 require more characters. Use one of these billable codes instead:
Use E85.0 for Non-neuropathic heredofamilial amyloidosis
Use E85.1 for Neuropathic heredofamilial amyloidosis
Use E85.2 for Heredofamilial amyloidosis, unspecified
Use E85.3 for Secondary systemic amyloidosis
Use E85.4 for Organ-limited amyloidosis
E85.8 for Other amyloidosis
Use E85.81 for Light chain (AL) amyloidosis
Use E85.82 for Wild-type transthyretin-related (ATTR) amyloidosis
Use E85.89 for Other amyloidosis
Use E85.9 for Amyloidosis, unspecified
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Type 2 Excludes
- Alzheimer's disease G30.0
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
Clinical InformationClinical
Amyloid Neuropathies, Familial
inherited disorders of the peripheral nervous system associated with the deposition of amyloid in nerve tissue. the different clinical types based on symptoms correspond to the presence of a variety of mutations in several different proteins including transthyretin (prealbumin); apolipoprotein a-i; and gelsolin.Amyloidosis
a group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of amyloid. as the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. various signs and symptoms depend on the location and size of the deposits.Amyloidosis, Familial
diseases in which there is a familial pattern of amyloidosis.Cerebral Amyloid Angiopathy, Familial
a familial disorder marked by amyloid deposits in the walls of small and medium sized blood vessels of cerebral cortex and meninges.Immunoglobulin Light-chain Amyloidosis
a nonproliferative disorder of plasma cells characterized by excessive production and misfolding of immunoglobulin light chains that form insoluble amyloid fibrils (see amyloid deposits) in various tissues. clinical features include liver failure; multiple myeloma; nephrotic syndrome; restrictive cardiomyopathy, and neuropathies.Amyloid
a fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. this fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. deposits of amyloid in the form of amyloid plaques are associated with a variety of degenerative diseases. the amyloid structure has also been found in a number of functional proteins that are unrelated to disease.
Patient EducationClinical
Amyloidosis
Amyloidosis occurs when abnormal proteins called amyloids build up and form deposits. The deposits can collect in organs such as the kidney and heart. This can cause the organs to become stiff and unable to work the way they should.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
