2027 ICD-10-CM Diagnosis Code E85Amyloidosis

ICD-10-CM Codes›E00–E89›E70-E88›E85

ICD-10-CM E85
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E85 is a non-billable ICD-10-CM category code for amyloidosis, so it cannot be submitted on claims. Use a more specific code from this category instead, such as E85.0, E85.1, E85.2, and E85.3.

Code Identity

ICD-10-CM Code
E85
Billable Status
No — Non-Billable Category
Code Describes
Amyloidosis
Short Description
Amyloidosis
Same as the full description in the CMS dataset.
Chapter
E70-E88
Metabolic disorders

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE85Amyloidosis
This CodeE85Amyloidosis

Specific Coding for AmyloidosisOverview

Non-specific codes like E85 require more characters. Use one of these billable codes instead:

  • Use E85.0 for Non-neuropathic heredofamilial amyloidosis

  • Use E85.1 for Neuropathic heredofamilial amyloidosis

  • Use E85.2 for Heredofamilial amyloidosis, unspecified

  • Use E85.3 for Secondary systemic amyloidosis

  • Use E85.4 for Organ-limited amyloidosis

  • E85.8 for Other amyloidosis

  • Use E85.81 for Light chain (AL) amyloidosis

  • Use E85.82 for Wild-type transthyretin-related (ATTR) amyloidosis

  • Use E85.89 for Other amyloidosis

  • Use E85.9 for Amyloidosis, unspecified

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E85: its own notes plus those printed at block E70-E88 and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Block E70-E88 Metabolic disorders applies to 286 codes
  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

On E85 itself
From Block E70-E88 Metabolic disorders applies to 286 codes
  • Ehlers-Danlos syndromes (Q79.6-)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E85, its category, or a range that includes it.

Excludes1 2

These codes carry an Excludes1 note naming E85: they are not reported together with it, unless the two conditions are unrelated.

Excludes2 3

These codes carry an Excludes2 note naming E85: its condition is not part of those codes, and both may be reported when the patient has both.

  • K76 Other diseases of liver
    amyloid degeneration of liver (E85.-)
  • N07 Hereditary nephropathy, not elsewhere classified
    hereditary amyloid nephropathy (E85.-)
  • N07 Hereditary nephropathy, not elsewhere classified
    non-neuropathic heredofamilial amyloidosis (E85.-)

Code First 15

These codes say to code first a condition named in the note, and E85 is one of the conditions named.

  • D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
    amyloidosis (E85.-)
  • G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere
    amyloidosis cerebral degeneration (E85.-)
  • G63 Polyneuropathy in diseases classified elsewhere
    amyloidosis (E85.-)
  • G99.0 Autonomic neuropathy in diseases classified elsewhere
    amyloidosis (E85.-)
  • G99.8 Other specified disorders of nervous system in diseases classified elsewhere
    amyloidosis (E85.-)
  • H42 Glaucoma in diseases classified elsewhere
    amyloidosis (E85.-)
  • I43 Cardiomyopathy in diseases classified elsewhere
    amyloidosis (E85.-)
  • I68.0 Cerebral amyloid angiopathy
    underlying amyloidosis (E85.-)
  • I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
    amyloidosis (E85.-)
  • J99 Respiratory disorders in diseases classified elsewhere
    amyloidosis (E85.-)
  • K77 Liver disorders in diseases classified elsewhere
    amyloidosis (E85.-)
  • L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
    amyloidosis (E85.-)
  • M14.8 Arthropathies in other specified diseases classified elsewhere
    amyloidosis (E85.-)
  • N08 Glomerular disorders in diseases classified elsewhere
    amyloidosis (E85.-)
  • N29 Other disorders of kidney and ureter in diseases classified elsewhere
    amyloidosis (E85.-)

Clinical InformationClinical

  • Amyloidosis

    a group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of amyloid. as the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. various signs and symptoms depend on the location and size of the deposits.

Patient EducationClinical

Amyloidosis

Amyloidosis occurs when abnormal proteins called amyloids build up and form deposits. The deposits can collect in organs such as the kidney and heart. This can cause the organs to become stiff and unable to work the way they should.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E85Overview

What is the ICD-10 code for amyloidosis?

E85 is the ICD-10-CM category for amyloidosis, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is E85 (Amyloidosis) a billable code?

No. This is a category header that groups the codes for amyloidosis, and headers cannot be submitted on claims. Claims for amyloidosis need a more specific code from this category, such as E85.0, E85.1, and E85.2.

Can E85 be reported with a code from E34.5?

Not as a rule. The Excludes1 note at block E70-E88, which applies to E85, lists "androgen insensitivity syndrome (E34.5-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).