Valid for Submission
D55.2 is a billable diagnosis code used to specify a medical diagnosis of anemia due to disorders of glycolytic enzymes. The code D55.2 is valid during the fiscal year 2021 from October 01, 2020 through September 30, 2021 for the submission of HIPAA-covered transactions.
The ICD-10-CM code D55.2 might also be used to specify conditions or terms like hemolytic anemia due to hexokinase deficiency, hemolytic anemia due to pyruvate kinase deficiency, hemolytic anemia due to triose phosphate isomerase deficiency, hnsha due to glucose phosphate isomerase deficiency, hnsha due to hexokinase deficiency , hnsha due to nadh diaphorase deficiency, etc.
Tabular List of Diseases and Injuries
The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code D55.2:
Inclusion TermsInclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
- Hemolytic nonspherocytic (hereditary) anemia, type II
- Hexokinase deficiency anemia
- Pyruvate kinase PK deficiency anemia
- Triose-phosphate isomerase deficiency anemia
Type 1 ExcludesType 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- disorders of glycolysis not associated with anemia E74.81
Index to Diseases and Injuries
The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code D55.2 are found in the index:
- - Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) - D64.9
- - with (due to) (in)
- - deficiency - D53.9
- - 2, 3 diphosphoglycurate mutase - D55.2
- - 2, 3 PG - D55.2
- - enzyme - D55.9
- - glycolytic - D55.2
- - glyceraldehyde phosphate dehydrogenase - D55.2
- - hexokinase - D55.2
- - phosphofructo-aldolase - D55.2
- - phosphoglycerate kinase - D55.2
- - PK - D55.2
- - pyruvate kinase - D55.2
- - triose-phosphate isomerase - D55.2
- - hemolytic - D58.9
- - hexokinase deficiency - D55.2
- - pyruvate kinase deficiency - D55.2
The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:
- Hemolytic anemia due to hexokinase deficiency
- Hemolytic anemia due to pyruvate kinase deficiency
- Hemolytic anemia due to triose phosphate isomerase deficiency
- HNSHA due to glucose phosphate isomerase deficiency
- HNSHA due to hexokinase deficiency
- HNSHA due to NADH diaphorase deficiency
- HNSHA due to phosphofructokinase deficiency
- HNSHA due to phosphoglycerate kinase deficiency
- HNSHA due to pyruvate kinase deficiency
- HNSHA due to triosephosphate isomerase deficiency
Diagnostic Related Groups - MS-DRG Mapping
Convert D55.2 to ICD-9 Code
The General Equivalency Mapping (GEM) crosswalk indicates an approximate mapping between the ICD-10 code D55.2 its ICD-9 equivalent. The approximate mapping means there is not an exact match between the ICD-10 code and the ICD-9 code and the mapped code is not a precise representation of the original code.
Information for Patients
Also called: Iron poor blood
If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.
Anemia has three main causes: blood loss, lack of red blood cell production, and high rates of red blood cell destruction.
Conditions that may lead to anemia include
- Heavy periods
- Colon polyps or colon cancer
- Inherited disorders
- A diet that does not have enough iron, folic acid or vitamin B12
- Blood disorders such as sickle cell anemia and thalassemia, or cancer
- Aplastic anemia, a condition that can be inherited or acquired
- G6PD deficiency, a metabolic disorder
Anemia can make you feel tired, cold, dizzy, and irritable. You may be short of breath or have a headache.
Your doctor will diagnose anemia with a physical exam and blood tests. Treatment depends on the kind of anemia you have.
NIH: National Heart, Lung, and Blood Institute
- Anemia (Medical Encyclopedia)
- Anemia - B12 deficiency (Medical Encyclopedia)
- Anemia caused by low iron -- infants and toddlers (Medical Encyclopedia)
- Anemia of chronic disease (Medical Encyclopedia)
- Anemia of Inflammation and Chronic Disease - NIH
- Febrile/cold agglutinins (Medical Encyclopedia)
- Ferritin blood test (Medical Encyclopedia)
- Hemolytic anemia (Medical Encyclopedia)
- Iron deficiency anemia (Medical Encyclopedia)
- Pernicious anemia (Medical Encyclopedia)
- Vitamin B12 level (Medical Encyclopedia)
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Triosephosphate isomerase deficiency Triosephosphate isomerase deficiency is a disorder characterized by a shortage of red blood cells (anemia), movement problems, increased susceptibility to infection, and muscle weakness that can affect breathing and heart function.The anemia in this condition begins in infancy. Since the anemia results from the premature breakdown of red blood cells (hemolysis), it is known as hemolytic anemia. A shortage of red blood cells to carry oxygen throughout the body leads to extreme tiredness (fatigue), pale skin (pallor), and shortness of breath. When the red cells are broken down, iron and a molecule called bilirubin are released; individuals with triosephosphate isomerase deficiency have an excess of these substances circulating in the blood. Excess bilirubin in the blood causes jaundice, which is a yellowing of the skin and the whites of the eyes.Movement problems typically become apparent by age 2 in people with triosephosphate isomerase deficiency. The movement problems are caused by impairment of motor neurons, which are specialized nerve cells in the brain and spinal cord that control muscle movement. This impairment leads to muscle weakness and wasting (atrophy) and causes the movement problems typical of triosephosphate isomerase deficiency, including involuntary muscle tensing (dystonia), tremors, and weak muscle tone (hypotonia). Affected individuals may also develop seizures.Weakness of other muscles, such as the heart (a condition known as cardiomyopathy) and the muscle that separates the abdomen from the chest cavity (the diaphragm) can also occur in triosephosphate isomerase deficiency. Diaphragm weakness can cause breathing problems and ultimately leads to respiratory failure.Individuals with triosephosphate isomerase deficiency are at increased risk of developing infections because they have poorly functioning white blood cells. These immune system cells normally recognize and attack foreign invaders, such as viruses and bacteria, to prevent infection. The most common infections in people with triosephosphate isomerase deficiency are bacterial infections of the respiratory tract.People with triosephosphate isomerase deficiency often do not survive past childhood due to respiratory failure. In a few rare cases, affected individuals without severe nerve damage or muscle weakness have lived into adulthood.
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Pyruvate kinase deficiency Pyruvate kinase deficiency is an inherited disorder that affects red blood cells, which carry oxygen to the body's tissues. People with this disorder have a condition known as chronic hemolytic anemia, in which red blood cells are broken down (undergo hemolysis) prematurely, resulting in a shortage of red blood cells (anemia). Specifically, pyruvate kinase deficiency is a common cause of a type of inherited hemolytic anemia called hereditary nonspherocytic hemolytic anemia. In hereditary nonspherocytic hemolytic anemia, the red blood cells do not assume a spherical shape as they do in some other forms of hemolytic anemia.Chronic hemolytic anemia can lead to unusually pale skin (pallor), yellowing of the eyes and skin (jaundice), extreme tiredness (fatigue), shortness of breath (dyspnea), and a rapid heart rate (tachycardia). An enlarged spleen (splenomegaly), an excess of iron in the blood, and small pebble-like deposits in the gallbladder or bile ducts (gallstones) are also common in this disorder.In people with pyruvate kinase deficiency, hemolytic anemia and associated complications may range from mild to severe. Some affected individuals have few or no symptoms. Severe cases can be life-threatening in infancy, and such affected individuals may require regular blood transfusions to survive. The symptoms of this disorder may get worse during an infection or pregnancy.
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