2026 ICD-10-CM Diagnosis Code E35Disorders of endocrine glands in diseases classified elsewhere
ICD-10-CM Codes›E00–E89›E20-E35›E35
- Billable — Valid for Submission
- Not Chronic
E35 is a billable ICD-10-CM diagnosis code for disorders of endocrine glands in diseases classified elsewhere. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. The code is a manifestation code that cannot be reported as the principal diagnosis. Coders also document this condition as endocrine infection. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for E35.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Endocrine infection
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Code First
- underlying disease, such as:
- late congenital syphilis of thymus gland Dubois disease A50.59
Use Additional Code
- code, if applicable, to identify:
- sequelae of tuberculosis of other organs B90.8
Type 1 Excludes
- Echinococcus granulosus infection of thyroid gland B67.3
- meningococcal hemorrhagic adrenalitis A39.1
- syphilis of endocrine gland A52.79
- tuberculosis of adrenal gland, except calcification A18.7
- tuberculosis of endocrine gland NEC A18.82
- tuberculosis of thyroid gland A18.81
- Waterhouse-Friderichsen syndrome A39.1
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Endocrine Diseases
Your endocrine system includes eight major glands throughout your body. These glands make hormones. Hormones are chemical messengers. They travel through your bloodstream to tissues or organs. Hormones work slowly and affect body processes from head to toe. These include:
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E35 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E35Overview
Is E35 a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report disorders of endocrine glands in diseases classified elsewhere on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does E35 group to?
On inpatient claims, disorders of endocrine glands in diseases classified elsewhere maps to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.
Can E35 be a principal diagnosis?
No. This is a manifestation code: disorders of endocrine glands in diseases classified elsewhere describes the manifestation of an underlying disease rather than the disease itself, so the underlying condition is sequenced first.
What is the ICD-9 equivalent of E35?
Under the General Equivalence Mappings, disorders of endocrine glands in diseases classified elsewhere converts to ICD-9-CM 246.8 (disorders of thyroid NEC), 255.8 (adrenal disorder NEC), and 259.8 (endocrine disorders NEC). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
