Metabolic disorders (E70-E88) ICD-10-CM
The E70–E88 section covers metabolic disorders with 366 ICD-10-CM diagnosis codes, of which 286 are billable in fiscal year 2027. The section is organized into the 17 code ranges listed below.
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- androgen insensitivity syndrome E34.5
- congenital adrenal hyperplasia E25.0
- hemolytic anemias attributable to enzyme disorders D55
- Marfan syndrome Q87.4
- 5-alpha-reductase deficiency E29.1
Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
- Ehlers-Danlos syndromes Q79.6
Code Ranges in This Section 17 ranges · 366 codes
The info icon previews the code ranges inside each row and its instructional notations from the official Tabular List.
About the E70–E88 Code Range
These conditions involve how the body processes substances, fluid balance, and conditions such as cystic fibrosis and amyloidosis. In amyloidosis, abnormally folded protein builds up and disrupts tissue function.
The categories first separate disorders by substance: aromatic amino acids in E70, branched-chain amino acids and fatty acids in E71, and other amino acids in E72. E73 covers lactose intolerance, while E74 covers other carbohydrate disorders. The next categories distinguish lipid storage disorders, glycosaminoglycans, glycoproteins, lipoproteins, purines and pyrimidines, porphyrins and bilirubin, and minerals.
E84 separates cystic fibrosis by its manifestations, including lung and intestinal manifestations. E85 separates forms of amyloidosis. E86 includes dehydration and low blood volume; E87 distinguishes fluid, electrolyte, and acid-base disorders. E88 holds other and unspecified metabolic disorders.
FY 2027 changes: The FY 2027 ICD-10-CM update, effective October 1, 2026, deleted E72.53, E78.01 and E88.1.
Questions About This Page
How many codes are in the E70-E88 range?
The E70-E88 range contains 366 ICD-10-CM diagnosis codes in FY 2027. 286 of them are billable, and the rest are category headers that organize the section.
What conditions does E70-E88 cover?
The range covers metabolic disorders. The code ranges listed above break it into groups of related conditions, and each one links to its own page with the full code list.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
