2027 ICD-10-CM Diagnosis Code R22Localized swelling, mass and lump of skin and subcutaneous tissue

ICD-10-CM Codes›R00–R99›R20-R23›R22

ICD-10-CM R22
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

R22 is a non-billable ICD-10-CM category code for localized swelling, mass and lump of skin and subcutaneous tissue, so it cannot be submitted on claims. Use a more specific code from this category instead, such as R22.0, R22.1, R22.2, and R22.30. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established.

Code Identity

ICD-10-CM Code
R22
Billable Status
No — Non-Billable Category
Code Describes
Localized swelling, mass and lump of skin and subcutaneous tissue
Short Description
Localized swelling, mass and lump of skin, subcu
Chapter
R20-R23
Symptoms and signs involving the skin and subcutaneous tissue

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR20-R23Symptoms and signs involving the skin and subcutaneous tissue
CategoryR22Localized swelling, mass and lump of skin and subcutaneous tissue
This CodeR22Localized swelling, mass and lump of skin and subcutaneous tissue

Specific Coding for Localized swelling, mass and lump of skin, subcuOverview

Non-specific codes like R22 require more characters. Use one of these billable codes instead:

  • Use R22.0 for Localized swelling, mass and lump, head

  • Use R22.1 for Localized swelling, mass and lump, neck

  • Use R22.2 for Localized swelling, mass and lump, trunk

  • R22.3 for Localized swelling, mass and lump, upper limb

  • Use R22.30 for Localized swelling, mass and lump, unspecified upper limb

  • Use R22.31 for Localized swelling, mass and lump, right upper limb

  • Use R22.32 for Localized swelling, mass and lump, left upper limb

  • Use R22.33 for Localized swelling, mass and lump, upper limb, bilateral

  • R22.4 for Localized swelling, mass and lump, lower limb

  • Use R22.40 for Localized swelling, mass and lump, unspecified lower limb

  • Use R22.41 for Localized swelling, mass and lump, right lower limb

  • Use R22.42 for Localized swelling, mass and lump, left lower limb

  • Use R22.43 for Localized swelling, mass and lump, lower limb, bilateral

  • Use R22.9 for Localized swelling, mass and lump, unspecified

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to R22: its own notes plus those printed at block R20-R23 and Chapter 18. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

  • subcutaneous nodules (localized)(superficial)

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

  • abnormal findings on diagnostic imaging (R90-R93)
  • edema (R60.-)
  • enlarged lymph nodes (R59.-)
  • localized adiposity (E65)
  • swelling of joint (M25.4-)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block R20-R23 Symptoms and signs involving the skin and subcutaneous tissue applies to 26 codes
From Chapter 18 (R00-R99) Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified applies to 774 codes
  • abnormal findings on antenatal screening of mother (O28.-)
  • certain conditions originating in the perinatal period (P04-P96)
  • signs and symptoms classified in the body system chapters
  • signs and symptoms of breast (N63, N64.5)

Notes

General instructions on how these codes are used.

From Chapter 18 (R00-R99) Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified applies to 774 codes
  • This chapter includes symptoms, signs, abnormal results of clinical or other investigative procedures, and ill-defined conditions regarding which no diagnosis classifiable elsewhere is recorded.
  • Signs and symptoms that point rather definitely to a given diagnosis have been assigned to a category in other chapters of the classification. In general, categories in this chapter include the less well-defined conditions and symptoms that, without the necessary study of the case to establish a final diagnosis, point perhaps equally to two or more diseases or to two or more systems of the body. Practically all categories in the chapter could be designated 'not otherwise specified', 'unknown etiology' or 'transient'. The Alphabetical Index should be consulted to determine which symptoms and signs are to be allocated here and which to other chapters. The residual subcategories, numbered .8, are generally provided for other relevant symptoms that cannot be allocated elsewhere in the classification.
  • The conditions and signs or symptoms included in categories R00-R94 consist of:
  • (a) cases for which no more specific diagnosis can be made even after all the facts bearing on the case have been investigated;
  • (b) signs or symptoms existing at the time of initial encounter that proved to be transient and whose causes could not be determined;
  • (c) provisional diagnosis in a patient who failed to return for further investigation or care;
  • (d) cases referred elsewhere for investigation or treatment before the diagnosis was made;
  • (e) cases in which a more precise diagnosis was not available for any other reason;
  • (f) certain symptoms, for which supplementary information is provided, that represent important problems in medical care in their own right.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name R22, its category, or a range that includes it.

Applicable To 1

These notes mention R22.

  • G71.038 Other limb girdle muscular dystrophy
    LGMD R22 collagen 6-related

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About R22Overview

What is the ICD-10 code for localized swelling, mass and lump of skin and subcutaneous tissue?

R22 is the ICD-10-CM category for localized swelling, mass and lump of skin and subcutaneous tissue, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is R22 a billable code?

No. This is a category header that groups the codes for localized swelling, mass and lump of skin and subcutaneous tissue, and headers cannot be submitted on claims. Claims for localized swelling, mass and lump of skin and subcutaneous tissue need a more specific code from this category, such as R22.0, R22.1, and R22.2.

Can R22 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the localized swelling, mass and lump of skin and subcutaneous tissue is established, that condition takes the principal position instead.

Can R22 be reported with a code from R60?

Not as a rule. The Excludes1 note on R22 lists "edema (R60.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).