2026 ICD-10-CM Diagnosis Code R22Localized swelling, mass and lump of skin and subcutaneous tissue

ICD-10-CM Codes›R00–R99›R20-R23›R22

ICD-10-CM R22
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R22 is a non-billable ICD-10-CM category code for localized swelling, mass and lump of skin and subcutaneous tissue, so it cannot be submitted on claims. Use a more specific code from this category instead, such as R22.0, R22.1, R22.2, and R22.30. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established.

Code Identity

ICD-10-CM Code
R22
Billable Status
No — Non-Billable Category
Code Describes
Localized swelling, mass and lump of skin and subcutaneous tissue
Short Description
Localized swelling, mass and lump of skin, subcu
Chapter
R20-R23
Symptoms and signs involving the skin and subcutaneous tissue

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR20-R23Symptoms and signs involving the skin and subcutaneous tissue
CategoryR22Localized swelling, mass and lump of skin and subcutaneous tissue
This CodeR22Localized swelling, mass and lump of skin and subcutaneous tissue

Specific Coding for Localized swelling, mass and lump of skin, subcuOverview

Non-specific codes like R22 require more characters. Use one of these billable codes instead:

  • Use R22.0 for Localized swelling, mass and lump, head

  • Use R22.1 for Localized swelling, mass and lump, neck

  • Use R22.2 for Localized swelling, mass and lump, trunk

  • R22.3 for Localized swelling, mass and lump, upper limb

  • Use R22.30 for Localized swelling, mass and lump, unspecified upper limb

  • Use R22.31 for Localized swelling, mass and lump, right upper limb

  • Use R22.32 for Localized swelling, mass and lump, left upper limb

  • Use R22.33 for Localized swelling, mass and lump, upper limb, bilateral

  • R22.4 for Localized swelling, mass and lump, lower limb

  • Use R22.40 for Localized swelling, mass and lump, unspecified lower limb

  • Use R22.41 for Localized swelling, mass and lump, right lower limb

  • Use R22.42 for Localized swelling, mass and lump, left lower limb

  • Use R22.43 for Localized swelling, mass and lump, lower limb, bilateral

  • Use R22.9 for Localized swelling, mass and lump, unspecified

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Includes

  • subcutaneous nodules (localized)(superficial)

Type 1 Excludes

  • abnormal findings on diagnostic imaging R90 R93
  • edema R60
  • enlarged lymph nodes R59
  • localized adiposity E65
  • swelling of joint M25.4

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R22Overview

Is R22 a billable code?

No. This is a category header that groups the codes for localized swelling, mass and lump of skin and subcutaneous tissue, and headers cannot be submitted on claims. Claims for localized swelling, mass and lump of skin and subcutaneous tissue need a more specific code from this category, such as R22.0, R22.1, and R22.2.

Can R22 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the localized swelling, mass and lump of skin and subcutaneous tissue is established, that condition takes the principal position instead.