2027 ICD-10-CM Diagnosis Code E78Disorders of lipoprotein metabolism and other lipidemias

ICD-10-CM Codes›E00–E89›E70-E88›E78

ICD-10-CM E78
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E78 is a non-billable ICD-10-CM category code for disorders of lipoprotein metabolism and other lipidemias, so it cannot be submitted on claims. Use a more specific code from this category instead, such as E78.00, E78.010, E78.011, and E78.019.

Code Identity

ICD-10-CM Code
E78
Billable Status
No — Non-Billable Category
Code Describes
Disorders of lipoprotein metabolism and other lipidemias
Short Description
Disorders of lipoprotein metabolism and other lipidemias
Same as the full description in the CMS dataset.
Chapter
E70-E88
Metabolic disorders

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE78Disorders of lipoprotein metabolism and other lipidemias
This CodeE78Disorders of lipoprotein metabolism and other lipidemias

Specific Coding for Disorders of lipoprotein metabolism and other lipidemiasOverview

Non-specific codes like E78 require more characters. Use one of these billable codes instead:

  • E78.0 for Pure hypercholesterolemia

  • Use E78.00 for Pure hypercholesterolemia, unspecified

  • E78.01 for Familial hypercholesterolemia

  • Use E78.1 for Pure hyperglyceridemia

  • Use E78.2 for Mixed hyperlipidemia

  • Use E78.3 for Hyperchylomicronemia

  • E78.4 for Other hyperlipidemia

  • Use E78.41 for Elevated Lipoprotein(a)

  • Use E78.49 for Other hyperlipidemia

  • Use E78.5 for Hyperlipidemia, unspecified

  • Use E78.6 for Lipoprotein deficiency

  • E78.7 for Disorders of bile acid and cholesterol metabolism

  • Use E78.70 for Disorder of bile acid and cholesterol metabolism, unspecified

  • Use E78.71 for Barth syndrome

  • Use E78.72 for Smith-Lemli-Opitz syndrome

  • Use E78.79 for Other disorders of bile acid and cholesterol metabolism

  • E78.8 for Other disorders of lipoprotein metabolism

  • Use E78.81 for Lipoid dermatoarthritis

  • Use E78.89 for Other lipoprotein metabolism disorders

  • Use E78.9 for Disorder of lipoprotein metabolism, unspecified

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E78: its own notes plus those printed at block E70-E88 and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

On E78 itself
From Block E70-E88 Metabolic disorders applies to 286 codes
  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block E70-E88 Metabolic disorders applies to 286 codes
  • Ehlers-Danlos syndromes (Q79.6-)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E78, its category, or a range that includes it.

Excludes2 2

These codes carry an Excludes2 note naming E78: its condition is not part of those codes, and both may be reported when the patient has both.

  • E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
    disorder of lipoprotein metabolism (E78.-)
  • Block R70-R79 Abnormal findings on examination of blood, without diagnosis
    abnormalities of lipids (E78.-)

Patient EducationClinical

Lipid Metabolism Disorders

Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system (enzymes) break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E78Overview

What is the ICD-10 code for disorders of lipoprotein metabolism and other lipidemias?

E78 is the ICD-10-CM category for disorders of lipoprotein metabolism and other lipidemias, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is E78 (Disorders of lipoprotein metabolism and other lipidemias) a billable code?

No. This is a category header that groups the codes for disorders of lipoprotein metabolism and other lipidemias, and headers cannot be submitted on claims. Claims for disorders of lipoprotein metabolism and other lipidemias need a more specific code from this category, such as E78.00, E78.010, and E78.011.

Can E78 be reported with a code from E34.5?

Not as a rule. The Excludes1 note at block E70-E88, which applies to E78, lists "androgen insensitivity syndrome (E34.5-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).