2021 ICD-10-CM Code E78

Disorders of lipoprotein metabolism and other lipidemias

Version 2021

Not Valid for Submission

E78 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of disorders of lipoprotein metabolism and other lipidemias. The code is not specific and is NOT valid for the year 2021 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

ICD-10:E78
Short Description:Disorders of lipoprotein metabolism and other lipidemias
Long Description:Disorders of lipoprotein metabolism and other lipidemias

Code Classification

Specific Coding for Disorders of lipoprotein metabolism and other lipidemias

Non-specific codes like E78 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10 codes with a higher level of specificity when coding for disorders of lipoprotein metabolism and other lipidemias:

  • NON-BILLABLE CODE - E78.0 for Pure hypercholesterolemia
  • BILLABLE CODE - Use E78.00 for Pure hypercholesterolemia, unspecified
  • BILLABLE CODE - Use E78.01 for Familial hypercholesterolemia
  • BILLABLE CODE - Use E78.1 for Pure hyperglyceridemia
  • BILLABLE CODE - Use E78.2 for Mixed hyperlipidemia
  • BILLABLE CODE - Use E78.3 for Hyperchylomicronemia
  • NON-BILLABLE CODE - E78.4 for Other hyperlipidemia
  • BILLABLE CODE - Use E78.41 for Elevated Lipoprotein(a)
  • BILLABLE CODE - Use E78.49 for Other hyperlipidemia
  • BILLABLE CODE - Use E78.5 for Hyperlipidemia, unspecified
  • BILLABLE CODE - Use E78.6 for Lipoprotein deficiency
  • NON-BILLABLE CODE - E78.7 for Disorders of bile acid and cholesterol metabolism
  • BILLABLE CODE - Use E78.70 for Disorder of bile acid and cholesterol metabolism, unspecified
  • BILLABLE CODE - Use E78.71 for Barth syndrome
  • BILLABLE CODE - Use E78.72 for Smith-Lemli-Opitz syndrome
  • BILLABLE CODE - Use E78.79 for Other disorders of bile acid and cholesterol metabolism
  • NON-BILLABLE CODE - E78.8 for Other disorders of lipoprotein metabolism
  • BILLABLE CODE - Use E78.81 for Lipoid dermatoarthritis
  • BILLABLE CODE - Use E78.89 for Other lipoprotein metabolism disorders
  • BILLABLE CODE - Use E78.9 for Disorder of lipoprotein metabolism, unspecified

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code E78:


Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

Information for Patients


Lipid Metabolism Disorders

Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system (enzymes) break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues. If you have a metabolic disorder, something goes wrong with this process.

Lipid metabolism disorders, such as Gaucher disease and Tay-Sachs disease, involve lipids. Lipids are fats or fat-like substances. They include oils, fatty acids, waxes, and cholesterol. If you have one of these disorders, you may not have enough enzymes to break down lipids. Or the enzymes may not work properly and your body can't convert the fats into energy. They cause a harmful amount of lipids to build up in your body. Over time, that can damage your cells and tissues, especially in the brain, peripheral nervous system, liver, spleen, and bone marrow. Many of these disorders can be very serious, or sometimes even fatal.

These disorders are inherited. Newborn babies get screened for some of them, using blood tests. If there is a family history of one of these disorders, parents can get genetic testing to see whether they carry the gene. Other genetic tests can tell whether the fetus has the disorder or carries the gene for the disorder.

Enzyme replacement therapies can help with a few of these disorders. For others, there is no treatment. Medicines, blood transfusions, and other procedures may help with complications.


[Learn More in MedlinePlus]

Code History

  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016 (First year ICD-10-CM implemented into the HIPAA code set)