2027 ICD-10-CM Diagnosis Code E52Niacin deficiency [pellagra]

ICD-10-CM Codes›E00–E89›E50-E64›E52

ICD-10-CM E52
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E52 is a billable ICD-10-CM diagnosis code for niacin deficiency [pellagra]. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 640 through 641. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Nutritional deficiencies.

Code Identity

ICD-10-CM Code
E52
Billable Status
Yes — Valid for Submission
Code Describes
Niacin deficiency [pellagra]
Short Description
Niacin deficiency [pellagra]
Same as the full description in the CMS dataset.
Chapter
E50-E64
Other nutritional deficiencies

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE50-E64Other nutritional deficiencies
CategoryE52Niacin deficiency [pellagra]
This CodeE52Niacin deficiency [pellagra]

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Alcoholic pellagra
  • Deficiency of isocitrate dehydrogenase
  • Dementia due to niacin deficiency
  • Dementia due to nutritional deficiency
  • Dementia due to pellagra
  • Inadequate intake of niacin
  • Niacin deficiency
  • Pellagra
  • Pellagra caused by drug
  • Pellagra neuropathy
  • Polyneuropathy in pellagra
  • Thiamine and niacin deficiency

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E52: its own notes plus those printed at block E50-E64 and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Niacin (-tryptophan) deficiency
  • Nicotinamide deficiency
  • Pellagra (alcoholic)

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

On E52 itself
  • sequelae of niacin deficiency (E64.8)
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block E50-E64 Other nutritional deficiencies applies to 50 codes

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E52, its category, or a range that includes it.

Applicable To 1

These notes mention E52.

  • P00.4 Newborn affected by maternal nutritional disorders
    Newborn affected by maternal disorders classifiable to E40-E64 names E40-E64, which includes this code

Excludes1 2

These codes carry an Excludes1 note naming E52: they are not reported together with it, unless the two conditions are unrelated.

  • T45.2X6 Underdosing of vitamins
    vitamin deficiencies (E50-E56) names E50-E56, which includes this code
  • Z72.4 Inappropriate diet and eating habits
    malnutrition and other nutritional deficiencies (E40-E64) names E40-E64, which includes this code

Code First 3

These codes say to code first a condition named in the note, and E52 is one of the conditions named.

  • F02 Dementia in other diseases classified elsewhere
    niacin deficiency [pellagra] (E52)
  • G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere
    cerebral degeneration (due to) vitamin B deficiency, except thiamine (E52-E53.-)
  • G63 Polyneuropathy in diseases classified elsewhere
    nutritional deficiency (E40-E64) names E40-E64, which includes this code

Notes 1

These notes mention E52.

  • E64 Sequelae of malnutrition and other nutritional deficiencies
    This category is to be used to indicate conditions in categories E43, E44, E46, E50-E63 as the cause of sequelae, which are themselves classified elsewhere. The 'sequelae' include conditions specified as such; they also include the late effects of diseases classifiable to the above categories if the disease itself is no longer present names E50-E63, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END007
Nutritional deficiencies
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Pellagra

    a disease due to deficiency of niacin, a b-complex vitamin, or its precursor tryptophan. it is characterized by scaly dermatitis which is often associated with diarrhea and dementia (the three d's).

Patient EducationClinical

B Vitamins

The B vitamins are:

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E52 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
265.2 Pellagra
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E52Overview

What is the ICD-10 code for niacin deficiency [pellagra]?

The ICD-10-CM code for niacin deficiency [pellagra] is E52. It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E52 (Niacin deficiency [pellagra]) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report niacin deficiency [pellagra] on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E52 group to?

When niacin deficiency [pellagra] is the principal diagnosis on an inpatient stay, it groups to MS-DRG 641, 640, with relative weights from 0.7864 to 1.3392 depending on complications. Higher weights mean higher Medicare reimbursement.

Can E52 be reported with E64.8?

Not as a rule. The Excludes1 note on E52 lists "sequelae of niacin deficiency (E64.8)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

What is the ICD-9 equivalent of E52?

Under the General Equivalence Mappings, niacin deficiency [pellagra] converts to ICD-9-CM 265.2 (pellagra). The mapping is a direct match.