2026 ICD-10-CM Diagnosis Code E52Niacin deficiency [pellagra]
ICD-10-CM Codes›E00–E89›E50-E64›E52
- Billable — Valid for Submission
- Not Chronic
E52 is a billable ICD-10-CM diagnosis code for niacin deficiency [pellagra]. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 640 through 641. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Nutritional deficiencies.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Alcoholic pellagra
- Deficiency of isocitrate dehydrogenase
- Dementia due to niacin deficiency
- Dementia due to nutritional deficiency
- Dementia due to pellagra
- Inadequate intake of niacin
- Niacin deficiency
- Pellagra
- Pellagra caused by drug
- Pellagra neuropathy
- Polyneuropathy in pellagra
- Thiamine and niacin deficiency
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Niacin (-tryptophan) deficiency
- Nicotinamide deficiency
- Pellagra (alcoholic)
Type 1 Excludes
- sequelae of niacin deficiency E64.8
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
amide nicotinic E52
nicotinic E52
Avitaminosis (multiple) See Also: Deficiency, vitamin; E56.9
nicotinic acid E52
Dementia (degenerative (primary)) (persisting) (unspecified severity) (without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety) F03.90
niacin deficiency See Also: Dementia, in, diseases specified elsewhere; E52
with behavioral disturbance See Also: Dementia, in, diseases specified elsewhere; E52
pellagra See Also: Dementia, in, diseases specified elsewhere; E52
with behavioral disturbance See Also: Dementia, in, diseases specified elsewhere; E52
polyneuropathy E52
Syndrome See Also: Disease;
pellagroid E52
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Pellagra
a disease due to deficiency of niacin, a b-complex vitamin, or its precursor tryptophan. it is characterized by scaly dermatitis which is often associated with diarrhea and dementia (the three d's).
Patient EducationClinical
B Vitamins
The B vitamins are:
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E52 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E52Overview
What is the ICD-10 code for niacin deficiency [pellagra]?
The ICD-10-CM code for niacin deficiency [pellagra] is E52. It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Is E52 (Niacin deficiency [pellagra]) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report niacin deficiency [pellagra] on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does E52 group to?
When niacin deficiency [pellagra] is the principal diagnosis on an inpatient stay, it groups to MS-DRG 640, 641, with relative weights from 0.7782 to 1.3356 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of E52?
Under the General Equivalence Mappings, niacin deficiency [pellagra] converts to ICD-9-CM 265.2 (pellagra). The mapping is a direct match.
