2026 ICD-10-CM Diagnosis Code E15Nondiabetic hypoglycemic coma
ICD-10-CM Codes›E00–E89›E15-E16›E15
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Not Chronic
E15 is a billable ICD-10-CM diagnosis code for nondiabetic hypoglycemic coma. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 640 through 641, 791, 793. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 355 closely related codes. Coders also document this condition as drug-induced coma. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Coma; stupor; and brain damage and Other specified and unspecified endocrine disorders.
E15 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 23 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, and ESRD (V24) category 23 for payment year 2026.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E15 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2026 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Drug-induced coma
- Drug-induced insulin coma in nondiabetic
- Hypoglycemic coma
- Insulin coma
- Non-diabetic hypoglycemic coma
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Includes
- drug-induced insulin coma in nondiabetic
- hyperinsulinism with hypoglycemic coma
- hypoglycemic coma NOS
This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
hypoglycemic (diabetic) See: Diabetes, by type, with hypoglycemia, with coma;
nondiabetic E15
Reaction See Also: Disorder;
hypoglycemic, due to insulin E16.0
with coma (diabetic) See: Diabetes, coma;
nondiabetic E15
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Convulsive Therapy
convulsions induced in order to treat mental disorders. it is used primarily in the treatment of severe affective disorders and schizophrenia.Insulin Coma
severe hypoglycemia induced by a large dose of exogenous insulin resulting in a coma or profound state of unconsciousness from which the individual cannot be aroused.Insulin Coma
a hypoglycemia-induced comatose state resulting from a large dose of exogenous insulin.Hypoglycemic Coma
a comatose state attributable to abnormally low serum glucose levels.
Patient EducationClinical
Coma
A coma is a deep state of unconsciousness. An individual in a coma is alive but unable to move or respond to his or her environment. Coma may occur as a complication of an underlying illness, or as a result of injuries, such as brain injury.
Read the full article at MedlinePlus
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Convert E15 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E15Overview
What is the ICD-10 code for nondiabetic hypoglycemic coma?
The ICD-10-CM code for nondiabetic hypoglycemic coma is E15. It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Is E15 (Nondiabetic hypoglycemic coma) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report nondiabetic hypoglycemic coma on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does E15 group to?
When nondiabetic hypoglycemic coma is the principal diagnosis on an inpatient stay, it groups to MS-DRG 640, 641, 791, 793, with relative weights from 0.7782 to 4.1696 depending on complications. Higher weights mean higher Medicare reimbursement.
Is E15 a CC or MCC?
CMS lists E15 as a CC (complication or comorbidity) for FY 2026. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 355 closely related codes in its exclusion list.
What is the ICD-9 equivalent of E15?
Under the General Equivalence Mappings, nondiabetic hypoglycemic coma converts to ICD-9-CM 251.0 (hypoglycemic coma). The mapping is a direct match.
Does E15 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. E15 mapped to HCC 23 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), and ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders).
