2027 ICD-10-CM Diagnosis Code E15Nondiabetic hypoglycemic coma

ICD-10-CM Codes›E00–E89›E15-E16›E15

ICD-10-CM E15
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E15 is a billable ICD-10-CM diagnosis code for nondiabetic hypoglycemic coma. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 640 through 641, 791, 793. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 355 closely related codes. Coders also document this condition as drug-induced coma. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Coma; stupor; and brain damage and Other specified and unspecified endocrine disorders.

E15 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 23 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, and ESRD (V24) category 23 for payment year 2027.

Code Identity

ICD-10-CM Code
E15
Billable Status
Yes — Valid for Submission
Code Describes
Nondiabetic hypoglycemic coma
Short Description
Nondiabetic hypoglycemic coma
Same as the full description in the CMS dataset.
Chapter
E15-E16
Other disorders of glucose regulation and pancreatic internal secretion

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE15-E16Other disorders of glucose regulation and pancreatic internal secretion
CategoryE15Nondiabetic hypoglycemic coma
This CodeE15Nondiabetic hypoglycemic coma

Medicare Risk Adjustment (HCC)Billing

E15 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.

CMS-HCC V28 (Medicare Advantage Payment Model)
Not mapped
Dropped in V28 see all codes that no longer risk-adjust
Prior Model (CMS-HCC V24)
HCC 23
V24 retired last contributed to a Medicare Advantage risk score in payment year 2025
Other CMS Models
PACE (CMS-HCC V22): HCC 23 · ESRD (V21): HCC 23 · ESRD (V24): HCC 23
ESRD V21 weights: 0.013 dialysis, 0.234–0.359 functioning graft · ESRD V24 weights: 0.036 dialysis, 0.217–0.390 functioning graft
Part D (RxHCC)
Not mapped
E15 does not risk-adjust in the RxHCC prescription drug model

Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Drug-induced coma
  • Drug-induced insulin coma in nondiabetic
  • Hypoglycemic coma
  • Insulin coma
  • Non-diabetic hypoglycemic coma

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E15: its own notes plus those printed at Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

  • drug-induced insulin coma in nondiabetic
  • hyperinsulinism with hypoglycemic coma
  • hypoglycemic coma NOS

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E15, its category, or a range that includes it.

Excludes1 1

These codes carry an Excludes1 note naming E15: they are not reported together with it, unless the two conditions are unrelated.

  • R40 Somnolence, stupor and coma
    somnolence, stupor and coma in hypoglycemia (nondiabetic) (E15)

Code First 1

These codes say to code first a condition named in the note, and E15 is one of the conditions named.

  • G63 Polyneuropathy in diseases classified elsewhere
    endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NVS013
Coma; stupor; and brain damage
Default principal diagnosis: inpatient No · outpatient No
CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Coma

A coma is a deep state of unconsciousness. An individual in a coma is alive but unable to move or respond to his or her environment. Coma may occur as a complication of an underlying illness, or as a result of injuries, such as brain injury.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E15 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
251.0 Hypoglycemic coma
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E15Overview

What is the ICD-10 code for nondiabetic hypoglycemic coma?

The ICD-10-CM code for nondiabetic hypoglycemic coma is E15. It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E15 (Nondiabetic hypoglycemic coma) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report nondiabetic hypoglycemic coma on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E15 group to?

When nondiabetic hypoglycemic coma is the principal diagnosis on an inpatient stay, it groups to MS-DRG 793, 791, 641, 640, with relative weights from 0.7864 to 4.2192 depending on complications. Higher weights mean higher Medicare reimbursement.

Is E15 a CC or MCC?

CMS lists E15 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 355 closely related codes in its exclusion list.

What is the ICD-9 equivalent of E15?

Under the General Equivalence Mappings, nondiabetic hypoglycemic coma converts to ICD-9-CM 251.0 (hypoglycemic coma). The mapping is a direct match.

Does E15 risk-adjust for Medicare Advantage payment?

Not for Medicare Advantage. E15 mapped to HCC 23 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), and ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders).