2026 ICD-10-CM Diagnosis Code E15Nondiabetic hypoglycemic coma

ICD-10-CM Codes›E00–E89›E15-E16›E15

ICD-10-CM E15
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E15 is a billable ICD-10-CM diagnosis code for nondiabetic hypoglycemic coma. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 640 through 641. Coders also document this condition as drug-induced coma. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Coma; stupor; and brain damage and Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E15
Billable Status
Yes — Valid for Submission
Code Describes
Nondiabetic hypoglycemic coma
Chapter
E15-E16
Other disorders of glucose regulation and pancreatic internal secretion

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE15-E16Other disorders of glucose regulation and pancreatic internal secretion
CategoryE15Nondiabetic hypoglycemic coma
This CodeE15Nondiabetic hypoglycemic coma

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Drug-induced coma
  • Drug-induced insulin coma in nondiabetic
  • Hypoglycemic coma
  • Insulin coma
  • Non-diabetic hypoglycemic coma

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Includes

  • drug-induced insulin coma in nondiabetic
  • hyperinsulinism with hypoglycemic coma
  • hypoglycemic coma NOS

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Coma
      • hypoglycemic (diabetic)
        • nondiabetic
    • Hyperinsulinism(functional)
      • with
        • coma (hypoglycemic)
    • Hypoglycemia(spontaneous)
      • coma
    • Hypoglycemia(spontaneous)
      • drug-induced
        • with coma (nondiabetic)
    • Hypoglycemia(spontaneous)
      • due to insulin
        • with coma (nondiabetic)
    • Hypoglycemia(spontaneous)
      • iatrogenic
        • with coma (nondiabetic)
    • Reaction
      • hypoglycemic, due to insulin
        • with coma (diabetic)
          • nondiabetic
    • Shock
      • insulin

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NVS013
Coma; stupor; and brain damage
Default principal diagnosis: inpatient No · outpatient No
CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Convulsive Therapy

    convulsions induced in order to treat mental disorders. it is used primarily in the treatment of severe affective disorders and schizophrenia.

  • Insulin Coma

    severe hypoglycemia induced by a large dose of exogenous insulin resulting in a coma or profound state of unconsciousness from which the individual cannot be aroused.

  • Insulin Coma

    a hypoglycemia-induced comatose state resulting from a large dose of exogenous insulin.

  • Hypoglycemic Coma

    a comatose state attributable to abnormally low serum glucose levels.

Patient EducationClinical

Coma

A coma is a deep state of unconsciousness. An individual in a coma is alive but unable to move or respond to his or her environment. Coma may occur as a complication of an underlying illness, or as a result of injuries, such as brain injury.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E15 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
251.0 Hypoglycemic coma
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E15Overview

Is E15 (Nondiabetic hypoglycemic coma) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report nondiabetic hypoglycemic coma on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E15 group to?

When nondiabetic hypoglycemic coma is the principal diagnosis on an inpatient stay, it groups to MS-DRG 640, 641, with relative weights from 0.7782 to 1.3356 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E15?

Under the General Equivalence Mappings, nondiabetic hypoglycemic coma converts to ICD-9-CM 251.0 (hypoglycemic coma). The mapping is a direct match.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.