2026 ICD-10-CM Diagnosis Code E84Cystic fibrosis

ICD-10-CM Codes›E00–E89›E70-E88›E84

ICD-10-CM E84
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E84 is a non-billable ICD-10-CM category code for cystic fibrosis, so it cannot be submitted on claims. Use a more specific code from this category instead, such as E84.0, E84.11, E84.19, and E84.8.

Code Identity

ICD-10-CM Code
E84
Billable Status
No — Non-Billable Category
Code Describes
Cystic fibrosis
Chapter
E70-E88
Metabolic disorders

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE84Cystic fibrosis
This CodeE84Cystic fibrosis

Specific Coding for Cystic fibrosisOverview

Non-specific codes like E84 require more characters. Use one of these billable codes instead:

  • Use E84.0 for Cystic fibrosis with pulmonary manifestations

  • E84.1 for Cystic fibrosis with intestinal manifestations

  • Use E84.11 for Meconium ileus in cystic fibrosis

  • Use E84.19 for Cystic fibrosis with other intestinal manifestations

  • Use E84.8 for Cystic fibrosis with other manifestations

  • Use E84.9 for Cystic fibrosis, unspecified

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Includes

  • mucoviscidosis

Code Also

  • exocrine pancreatic insufficiency K86.81

Clinical InformationClinical

  • Calgranulin A

    a 10.8-kda member of the s-100 family of calcium-binding proteins that can form homo- or heterocomplexes with calgranulin b and a variety of other proteins. the calgranulin a/b heterodimer is known as leukocyte l1 antigen complex. calgranulin a is found in many cell types including granulocytes; keratinocytes; and myelomonocytes, and has been shown to act as a chemotactic substance for neutrophils. because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions.

  • Cystic Fibrosis

    an autosomal recessive genetic disease of the exocrine glands. it is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator expressed in several organs including the lung, the pancreas, the biliary system, and the sweat glands. cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in airway obstruction; chronic respiratory infections; pancreatic insufficiency; maldigestion; salt depletion; and heat prostration.

  • Cystic Fibrosis Transmembrane Conductance Regulator

    a chloride channel that regulates secretion in many exocrine tissues. abnormalities in the cftr gene have been shown to cause cystic fibrosis. (hum genet 1994;93(4):364-8)

Patient EducationClinical

Cystic Fibrosis

Cystic fibrosis (CF) is an inherited disease of the mucus and sweat glands. It affects mostly your lungs, pancreas, liver, intestines, sinuses, and sex organs. CF causes your mucus to be thick and sticky. The mucus clogs the lungs, causing breathing problems and making it easy for bacteria to grow.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E84Overview

Is E84 (Cystic fibrosis) a billable code?

No. This is a category header that groups the codes for cystic fibrosis, and headers cannot be submitted on claims. Claims for cystic fibrosis need a more specific code from this category, such as E84.0, E84.11, and E84.19.