ICD-10-CM Tag List · Table of Drugs · FY 2027 175 Codes

2027 Adverse Effects ICD-10-CM Codes ICD-10-CM

The FY 2027 dataset contains 175 adverse effects codes across 15 code blocks. Adverse effect codes document harmful or unintended reactions to drugs and substances taken correctly, as prescribed or directed. These are not poisonings; they are side effects of proper use. Each code below lists the substances that map to it in the Table of Drugs and Chemicals.

✓ Built from the official CMS FY 2027 datasetEffective Oct 1, 2026 – Sep 30, 2027
175
Codes
15
Code Blocks
0
Billable
FY 2027
Dataset

Coding Guidance

Code the nature of the adverse effect first (the rash, the bradycardia), followed by the adverse effect code identifying the drug. If the drug was misused or the dose was wrong, the poisoning columns apply instead.

ICD-10-CM

All Adverse Effects Codes 175 codes · searchable by substance

175 of 175 shown

Poisoning by, adverse effect of and underdosing of systemic antibiotics T36 · 11 codes

  • T36.0X5 Adverse effect of penicillinsNon-billable header
  • T36.1X5 Adverse effect of cephalosporins and other beta-lactam antibioticsNon-billable header
  • T36.2X5 Adverse effect of chloramphenicol groupNon-billable header
  • T36.3X5 Adverse effect of macrolidesNon-billable header
  • T36.4X5 Adverse effect of tetracyclinesNon-billable header
  • T36.5X5 Adverse effect of aminoglycosidesNon-billable header
  • T36.6X5 Adverse effect of rifampicinsNon-billable header
  • T36.7X5 Adverse effect of antifungal antibiotics, systemically usedNon-billable header
  • T36.8X5 Adverse effect of other systemic antibioticsNon-billable header
  • T36.95 Adverse effect of unspecified systemic antibioticNon-billable header
  • T36.AX5 Adverse effect of fluoroquinolone antibioticsNon-billable header

Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics T37 · 8 codes

  • T37.0X5 Adverse effect of sulfonamidesNon-billable header
  • T37.1X5 Adverse effect of antimycobacterial drugsNon-billable header
  • T37.2X5 Adverse effect of antimalarials and drugs acting on other blood protozoaNon-billable header
  • T37.3X5 Adverse effect of other antiprotozoal drugsNon-billable header
  • T37.4X5 Adverse effect of anthelminthicsNon-billable header
  • T37.5X5 Adverse effect of antiviral drugsNon-billable header
  • T37.8X5 Adverse effect of other specified systemic anti-infectives and antiparasiticsNon-billable header
  • T37.95 Adverse effect of unspecified systemic anti-infective and antiparasiticNon-billable header

Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified T38 · 13 codes

  • T38.0X5 Adverse effect of glucocorticoids and synthetic analoguesNon-billable header
  • T38.1X5 Adverse effect of thyroid hormones and substitutesNon-billable header
  • T38.2X5 Adverse effect of antithyroid drugsNon-billable header
  • T38.3X5 Adverse effect of insulin and oral hypoglycemic [antidiabetic] drugsNon-billable header
  • T38.4X5 Adverse effect of oral contraceptivesNon-billable header
  • T38.5X5 Adverse effect of other estrogens and progestogensNon-billable header
  • T38.6X5 Adverse effect of antigonadotrophins, antiestrogens, antiandrogens, not elsewhere classifiedNon-billable header
  • T38.7X5 Adverse effect of androgens and anabolic congenersNon-billable header
  • T38.805 Adverse effect of unspecified hormones and synthetic substitutesNon-billable header
  • T38.815 Adverse effect of anterior pituitary [adenohypophyseal] hormonesNon-billable header
  • T38.895 Adverse effect of other hormones and synthetic substitutesNon-billable header
  • T38.905 Adverse effect of unspecified hormone antagonistsNon-billable header
  • T38.995 Adverse effect of other hormone antagonistsNon-billable header

Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics T39 · 9 codes

  • T39.015 Adverse effect of aspirinNon-billable header
  • T39.095 Adverse effect of salicylatesNon-billable header
  • T39.1X5 Adverse effect of 4-Aminophenol derivativesNon-billable header
  • T39.2X5 Adverse effect of pyrazolone derivativesNon-billable header
  • T39.315 Adverse effect of propionic acid derivativesNon-billable header
  • T39.395 Adverse effect of other nonsteroidal anti-inflammatory drugs [NSAID]Non-billable header
  • T39.4X5 Adverse effect of antirheumatics, not elsewhere classifiedNon-billable header
  • T39.8X5 Adverse effect of other nonopioid analgesics and antipyretics, not elsewhere classifiedNon-billable header
  • T39.95 Adverse effect of unspecified nonopioid analgesic, antipyretic and antirheumaticNon-billable header

Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens] T40 · 13 codes

  • T40.0X5 Adverse effect of opiumNon-billable header
  • T40.2X5 Adverse effect of other opioidsNon-billable header
  • T40.3X5 Adverse effect of methadoneNon-billable header
  • T40.415 Adverse effect of fentanyl or fentanyl analogsNon-billable header
  • T40.425 Adverse effect of tramadolNon-billable header
  • T40.495 Adverse effect of other synthetic narcoticsNon-billable header
  • T40.5X5 Adverse effect of cocaineNon-billable header
  • T40.605 Adverse effect of unspecified narcoticsNon-billable header
  • T40.695 Adverse effect of other narcoticsNon-billable header
  • T40.715 Adverse effect of cannabisNon-billable header
  • T40.725 Adverse effect of synthetic cannabinoidsNon-billable header
  • T40.905 Adverse effect of unspecified psychodysleptics [hallucinogens]Non-billable header
  • T40.995 Adverse effect of other psychodysleptics [hallucinogens]Non-billable header

Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gases T41 · 7 codes

  • T41.0X5 Adverse effect of inhaled anestheticsNon-billable header
  • T41.1X5 Adverse effect of intravenous anestheticsNon-billable header
  • T41.205 Adverse effect of unspecified general anestheticsNon-billable header
  • T41.295 Adverse effect of other general anestheticsNon-billable header
  • T41.3X5 Adverse effect of local anestheticsNon-billable header
  • T41.45 Adverse effect of unspecified anestheticNon-billable header
  • T41.5X5 Adverse effect of therapeutic gasesNon-billable header

Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs T42 · 9 codes

  • T42.0X5 Adverse effect of hydantoin derivativesNon-billable header
  • T42.1X5 Adverse effect of iminostilbenesNon-billable header
  • T42.2X5 Adverse effect of succinimides and oxazolidinedionesNon-billable header
  • T42.3X5 Adverse effect of barbituratesNon-billable header
  • T42.4X5 Adverse effect of benzodiazepinesNon-billable header
  • T42.5X5 Adverse effect of mixed antiepilepticsNon-billable header
  • T42.6X5 Adverse effect of other antiepileptic and sedative-hypnotic drugsNon-billable header
  • T42.75 Adverse effect of unspecified antiepileptic and sedative-hypnotic drugsNon-billable header
  • T42.8X5 Adverse effect of antiparkinsonism drugs and other central muscle-tone depressantsNon-billable header

Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified T43 · 19 codes

  • T43.015 Adverse effect of tricyclic antidepressantsNon-billable header
  • T43.025 Adverse effect of tetracyclic antidepressantsNon-billable header
  • T43.1X5 Adverse effect of monoamine-oxidase-inhibitor antidepressantsNon-billable header
  • T43.205 Adverse effect of unspecified antidepressantsNon-billable header
  • T43.215 Adverse effect of selective serotonin and norepinephrine reuptake inhibitorsNon-billable header
  • T43.225 Adverse effect of selective serotonin reuptake inhibitorsNon-billable header
  • T43.295 Adverse effect of other antidepressantsNon-billable header
  • T43.3X5 Adverse effect of phenothiazine antipsychotics and neurolepticsNon-billable header
  • T43.4X5 Adverse effect of butyrophenone and thiothixene neurolepticsNon-billable header
  • T43.505 Adverse effect of unspecified antipsychotics and neurolepticsNon-billable header
  • T43.595 Adverse effect of other antipsychotics and neurolepticsNon-billable header
  • T43.605 Adverse effect of unspecified psychostimulantsNon-billable header
  • T43.615 Adverse effect of caffeineNon-billable header
  • T43.625 Adverse effect of amphetaminesNon-billable header
  • T43.635 Adverse effect of methylphenidateNon-billable header
  • T43.655 Adverse effect of methamphetaminesNon-billable header
  • T43.695 Adverse effect of other psychostimulantsNon-billable header
  • T43.8X5 Adverse effect of other psychotropic drugsNon-billable header
  • T43.95 Adverse effect of unspecified psychotropic drugNon-billable header

Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system T44 · 11 codes

  • T44.0X5 Adverse effect of anticholinesterase agentsNon-billable header
  • T44.1X5 Adverse effect of other parasympathomimetics [cholinergics]Non-billable header
  • T44.2X5 Adverse effect of ganglionic blocking drugsNon-billable header
  • T44.3X5 Adverse effect of other parasympatholytics [anticholinergics and antimuscarinics] and spasmolyticsNon-billable header
  • T44.4X5 Adverse effect of predominantly alpha-adrenoreceptor agonistsNon-billable header
  • T44.5X5 Adverse effect of predominantly beta-adrenoreceptor agonistsNon-billable header
  • T44.6X5 Adverse effect of alpha-adrenoreceptor antagonistsNon-billable header
  • T44.7X5 Adverse effect of beta-adrenoreceptor antagonistsNon-billable header
  • T44.8X5 Adverse effect of centrally-acting and adrenergic-neuron-blocking agentsNon-billable header
  • T44.905 Adverse effect of unspecified drugs primarily affecting the autonomic nervous systemNon-billable header
  • T44.995 Adverse effect of other drug primarily affecting the autonomic nervous systemNon-billable header

Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified T45 · 15 codes

  • T45.0X5 Adverse effect of antiallergic and antiemetic drugsNon-billable header
  • T45.1X5 Adverse effect of antineoplastic and immunosuppressive drugsNon-billable header
  • T45.2X5 Adverse effect of vitaminsNon-billable header
  • T45.3X5 Adverse effect of enzymesNon-billable header
  • T45.4X5 Adverse effect of iron and its compoundsNon-billable header
  • T45.515 Adverse effect of anticoagulantsNon-billable header
  • T45.525 Adverse effect of antithrombotic drugsNon-billable header
  • T45.605 Adverse effect of unspecified fibrinolysis-affecting drugsNon-billable header
  • T45.615 Adverse effect of thrombolytic drugsNon-billable header
  • T45.625 Adverse effect of hemostatic drugNon-billable header
  • T45.695 Adverse effect of other fibrinolysis-affecting drugsNon-billable header
  • T45.7X5 Adverse effect of anticoagulant antagonists, vitamin K and other coagulantsNon-billable header
  • T45.8X5 Adverse effect of other primarily systemic and hematological agentsNon-billable header
  • T45.95 Adverse effect of unspecified primarily systemic and hematological agentNon-billable header
  • T45.AX5 Adverse effect of immune checkpoint inhibitors and immunostimulant drugsNon-billable header

Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system T46 · 11 codes

  • T46.0X5 Adverse effect of cardiac-stimulant glycosides and drugs of similar actionNon-billable header
  • T46.1X5 Adverse effect of calcium-channel blockersNon-billable header
  • T46.2X5 Adverse effect of other antidysrhythmic drugsNon-billable header
  • T46.3X5 Adverse effect of coronary vasodilatorsNon-billable header
  • T46.4X5 Adverse effect of angiotensin-converting-enzyme inhibitorsNon-billable header
  • T46.5X5 Adverse effect of other antihypertensive drugsNon-billable header
  • T46.6X5 Adverse effect of antihyperlipidemic and antiarteriosclerotic drugsNon-billable header
  • T46.7X5 Adverse effect of peripheral vasodilatorsNon-billable header
  • T46.8X5 Adverse effect of antivaricose drugs, including sclerosing agentsNon-billable header
  • T46.905 Adverse effect of unspecified agents primarily affecting the cardiovascular systemNon-billable header
  • T46.995 Adverse effect of other agents primarily affecting the cardiovascular systemNon-billable header

Poisoning by, adverse effect of and underdosing of agents primarily affecting the gastrointestinal system T47 · 10 codes

  • T47.0X5 Adverse effect of histamine H2-receptor blockersNon-billable header
  • T47.1X5 Adverse effect of other antacids and anti-gastric-secretion drugsNon-billable header
  • T47.2X5 Adverse effect of stimulant laxativesNon-billable header
  • T47.3X5 Adverse effect of saline and osmotic laxativesNon-billable header
  • T47.4X5 Adverse effect of other laxativesNon-billable header
  • T47.5X5 Adverse effect of digestantsNon-billable header
  • T47.6X5 Adverse effect of antidiarrheal drugsNon-billable header
  • T47.7X5 Adverse effect of emeticsNon-billable header
  • T47.8X5 Adverse effect of other agents primarily affecting gastrointestinal systemNon-billable header
  • T47.95 Adverse effect of unspecified agents primarily affecting the gastrointestinal systemNon-billable header

Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory system T48 · 10 codes

  • T48.0X5 Adverse effect of oxytocic drugsNon-billable header
  • T48.1X5 Adverse effect of skeletal muscle relaxants [neuromuscular blocking agents]Non-billable header
  • T48.205 Adverse effect of unspecified drugs acting on musclesNon-billable header
  • T48.295 Adverse effect of other drugs acting on musclesNon-billable header
  • T48.3X5 Adverse effect of antitussivesNon-billable header
  • T48.4X5 Adverse effect of expectorantsNon-billable header
  • T48.5X5 Adverse effect of other anti-common-cold drugsNon-billable header
  • T48.6X5 Adverse effect of antiasthmaticsNon-billable header
  • T48.905 Adverse effect of unspecified agents primarily acting on the respiratory systemNon-billable header
  • T48.995 Adverse effect of other agents primarily acting on the respiratory systemNon-billable header

Poisoning by, adverse effect of and underdosing of topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinorlaryngological and dental drugs T49 · 10 codes

  • T49.0X5 Adverse effect of local antifungal, anti-infective and anti-inflammatory drugsNon-billable header
  • T49.1X5 Adverse effect of antipruriticsNon-billable header
  • T49.2X5 Adverse effect of local astringents and local detergentsNon-billable header
  • T49.3X5 Adverse effect of emollients, demulcents and protectantsNon-billable header
  • T49.4X5 Adverse effect of keratolytics, keratoplastics, and other hair treatment drugs and preparationsNon-billable header
  • T49.5X5 Adverse effect of ophthalmological drugs and preparationsNon-billable header
  • T49.6X5 Adverse effect of otorhinolaryngological drugs and preparationsNon-billable header
  • T49.7X5 Adverse effect of dental drugs, topically appliedNon-billable header
  • T49.8X5 Adverse effect of other topical agentsNon-billable header
  • T49.95 Adverse effect of unspecified topical agentNon-billable header

Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances T50 · 19 codes

  • T50.0X5 Adverse effect of mineralocorticoids and their antagonistsNon-billable header
  • T50.1X5 Adverse effect of loop [high-ceiling] diureticsNon-billable header
  • T50.2X5 Adverse effect of carbonic-anhydrase inhibitors, benzothiadiazides and other diureticsNon-billable header
  • T50.3X5 Adverse effect of electrolytic, caloric and water-balance agentsNon-billable header
  • T50.4X5 Adverse effect of drugs affecting uric acid metabolismNon-billable header
  • T50.5X5 Adverse effect of appetite depressantsNon-billable header
  • T50.6X5 Adverse effect of antidotes and chelating agentsNon-billable header
  • T50.7X5 Adverse effect of analeptics and opioid receptor antagonistsNon-billable header
  • T50.8X5 Adverse effect of diagnostic agentsNon-billable header
  • T50.905 Adverse effect of unspecified drugs, medicaments and biological substancesNon-billable header
  • T50.915 Adverse effect of multiple unspecified drugs, medicaments and biological substancesNon-billable header
  • T50.995 Adverse effect of other drugs, medicaments and biological substancesNon-billable header
  • T50.A15 Adverse effect of pertussis vaccine, including combinations with a pertussis componentNon-billable header
  • T50.A25 Adverse effect of mixed bacterial vaccines without a pertussis componentNon-billable header
  • T50.A95 Adverse effect of other bacterial vaccinesNon-billable header
  • T50.B15 Adverse effect of smallpox vaccinesNon-billable header
  • T50.B95 Adverse effect of other viral vaccinesNon-billable header
  • T50.Z15 Adverse effect of immunoglobulinNon-billable header
  • T50.Z95 Adverse effect of other vaccines and biological substancesNon-billable header

The info icon lists every substance from the table that maps to the code. The filter above searches those substances too.

Questions About This Page

How do I find the right code for a specific drug?

Type the substance into the filter above. Every code on this page carries its full substance list from the Table of Drugs and Chemicals. For the complete six-column table, use the Table of Drugs and Chemicals.

Do these codes need an external cause code?

No. Poisoning, adverse effect, and underdosing codes from the T36 to T65 range carry the intent inside the code itself, so no additional external cause code is reported with them.

What 7th character do these codes take?

A for the initial encounter during active treatment, D for subsequent encounters during recovery, and S for sequela when coding late effects.

How many adverse effects codes are there?

The FY 2027 dataset contains 175 adverse effects codes across 15 code blocks.

Related References

Source: official CMS FY 2027 ICD-10-CM release, effective October 1, 2026 through September 30, 2027.