ICD-10-CM Code E16.8

Other specified disorders of pancreatic internal secretion

Version 2021 Billable Code

Valid for Submission

E16.8 is a billable code used to specify a medical diagnosis of other specified disorders of pancreatic internal secretion. The code is valid for the fiscal year 2021 for the submission of HIPAA-covered transactions. The ICD-10-CM code E16.8 might also be used to specify conditions or terms like abnormal hormone secretion, abnormality of bombesin secretion, abnormality of cholecystokinin-pancreozymin secretion, abnormality of gastric inhibitory peptide secretion, abnormality of glicentin secretion, abnormality of motilin secretion, etc

Short Description:Other specified disorders of pancreatic internal secretion
Long Description:Other specified disorders of pancreatic internal secretion

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code E16.8:

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Increased secretion from endocrine pancreas of growth hormone-releasing hormone
  • Increased secretion from endocrine pancreas of pancreatic polypeptide
  • Increased secretion from endocrine pancreas of somatostatin
  • Increased secretion from endocrine pancreas of vasoactive-intestinal polypeptide

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code E16.8 are found in the index:


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Abnormal hormone secretion
  • Abnormality of bombesin secretion
  • Abnormality of cholecystokinin-pancreozymin secretion
  • Abnormality of gastric inhibitory peptide secretion
  • Abnormality of glicentin secretion
  • Abnormality of motilin secretion
  • Abnormality of pancreatic polypeptide secretion
  • Abnormality of secretin secretion
  • Abnormality of secretion of gastrin
  • Abnormality of secretion of glucagon
  • Abnormality of somatostatin secretion
  • Abnormality of vasoactive intestinal peptide secretion
  • Diminished gastrin secretion
  • Excessive bombesin secretion
  • Excessive cholecystokinin-pancreozymin secretion
  • Excessive gastric inhibitory peptide secretion
  • Excessive glicentin secretion
  • Excessive motilin secretion
  • Excessive pancreatic polypeptide secretion
  • Excessive secretin secretion
  • Excessive somatostatin secretion
  • Glucagon deficiency
  • Hypoinsulinemic hypoglycemia and body hemihypertrophy
  • Hypoinsulinism
  • Hypoinsulinism
  • Neonatal disorder of endocrine system
  • Neonatal hypoglycemia
  • Non-diabetic disorder of endocrine pancreas
  • Non-diabetic disorder of endocrine pancreas
  • Verner-Morrison syndrome

Diagnostic Related Groups

The ICD-10 code E16.8 is grouped in the following groups for version MS-DRG V38.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2020 through 09/30/2021.


Convert E16.8 to ICD-9

  • 251.8 - Pancreatic disorder NEC (Approximate Flag)

Code Classification

  • Endocrine, nutritional and metabolic diseases (E00–E90)
    • Other disorders of glucose regulation and pancreatic internal secretion (E15-E16)
      • Other disorders of pancreatic internal secretion (E16)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients

Pancreatic Diseases

The pancreas is a gland behind your stomach and in front of your spine. It produces juices that help break down food and hormones that help control blood sugar levels. Problems with the pancreas can lead to many health problems. These include

  • Pancreatitis, or inflammation of the pancreas: This happens when digestive enzymes start digesting the pancreas itself
  • Pancreatic cancer
  • Cystic fibrosis, a genetic disorder in which thick, sticky mucus can also block tubes in your pancreas

The pancreas also plays a role in diabetes. In type 1 diabetes, the beta cells of the pancreas no longer make insulin because the body's immune system has attacked them. In type 2 diabetes, the pancreas loses the ability to secrete enough insulin in response to meals.

  • Acute pancreatitis (Medical Encyclopedia)
  • Amylase - blood (Medical Encyclopedia)
  • Annular pancreas (Medical Encyclopedia)
  • ERCP (Medical Encyclopedia)
  • Lipase test (Medical Encyclopedia)
  • Pancreatic pseudocyst (Medical Encyclopedia)
  • Zollinger-Ellison syndrome (Medical Encyclopedia)

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