ICD-10-CM Code E27.4

Other and unspecified adrenocortical insufficiency

Version 2021 Non-Billable Code

Not Valid for Submission

E27.4 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of other and unspecified adrenocortical insufficiency. The code is NOT valid for the year 2021 for the submission of HIPAA-covered transactions.

ICD-10:E27.4
Short Description:Other and unspecified adrenocortical insufficiency
Long Description:Other and unspecified adrenocortical insufficiency

Consider the following ICD-10 codes with a higher level of specificity:

  • E27.40 - Unspecified adrenocortical insufficiency
  • E27.49 - Other adrenocortical insufficiency

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code E27.4:

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • adrenoleukodystrophy Addison-Schilder E71.528
  • Waterhouse-Friderichsen syndrome A39.1

Code Classification

  • Endocrine, nutritional and metabolic diseases (E00–E90)
    • Disorders of other endocrine glands (E20-E35)
      • Other disorders of adrenal gland (E27)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients


Addison Disease

Also called: Adrenal insufficiency, Adrenocortical hypofunction, Hypocortisolism

Your adrenal glands are just above your kidneys. The outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. Addison disease happens if the adrenal glands don't make enough of these hormones.

A problem with your immune system usually causes Addison disease. The immune system mistakenly attacks your own tissues, damaging your adrenal glands. Other causes include infections and cancer.

Symptoms include

  • Weight loss
  • Muscle weakness
  • Fatigue that gets worse over time
  • Low blood pressure
  • Patchy or dark skin

Lab tests can confirm that you have Addison disease. If you don't treat it, it can be fatal. You will need to take hormone pills for the rest of your life. If you have Addison disease, you should carry an emergency ID. It should say that you have the disease, list your medicines and say how much you need in an emergency.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

  • ACTH (cosyntropin) stimulation test (Medical Encyclopedia)
  • ACTH blood test (Medical Encyclopedia)
  • Acute adrenal crisis (Medical Encyclopedia)
  • Addison disease (Medical Encyclopedia)
  • Cortisol level (Medical Encyclopedia)

[Learn More]