2024 ICD-10-CM Diagnosis Code D72.0

Genetic anomalies of leukocytes

ICD-10-CM Code:
ICD-10 Code for:
Genetic anomalies of leukocytes
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Code Navigator:

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
    • Other disorders of blood and blood-forming organs
      • Other disorders of white blood cells

D72.0 is a billable diagnosis code used to specify a medical diagnosis of genetic anomalies of leukocytes. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Combined phagocytic defect
  • Congenital atrophy of optic nerve
  • De Vaal's syndrome
  • Defective phagocytic cell adhesion
  • Defective phagocytic cell adhesion
  • Genetic anomaly of leukocyte
  • Genetic anomaly of leukocyte
  • Hereditary hypersegmentation
  • Hereditary neutrophilia
  • Hypersegmentation
  • Leukocyte adhesion deficiency
  • Leukocyte adhesion deficiency
  • Leukocyte adhesion deficiency - type 1
  • Leukocyte adhesion deficiency - type 2
  • Neutrophilia
  • Neutrophilia disorder
  • Pelger-Huët anomaly
  • Pelger-Huët anomaly
  • Pelger-Huët cell
  • Pelger-Huët cell
  • Reticular dysgenesis
  • Reticular dysgenesis
  • Reticular dysgenesis with congenital aleukocytosis
  • SCID due to absent peripheral T cell maturation
  • SCID due to absent peripheral T cell maturation
  • SCID due to absent peripheral T cell maturation
  • Short stature, optic nerve atrophy, Pelger-Huët anomaly syndrome

Clinical Classification

Clinical Information

  • Reticular Dysgenesis

    a rare severe combined immunodeficiency disorder characterized by congenital agranulocytosis, lymphoid tissue and thymic tissue hypoplasia, and lymphopenia. both cellular and humoral immunities are absent.
  • Leukocyte Adhesion Deficiency

    a rare autosomal recessive immunodeficiency disorder caused by deficiency of cd18 expression. it is characterized by defects in neutrophil adhesion and bacterial infections.
  • Leukocyte Adhesion Deficiency Type 1|LAD-1|LAD-1 Deficiency|LAD-Type I|LAD1|LFA-I Deficiency|LFA1 Immunodeficiency

    a rare immunodeficiency with an autosomal recessive pattern of inheritance. it is caused by mutation in the itgb2 gene on chromosome 21 which codes for the beta subunit of beta-2 integrin (cd18). the mutation results in significantly reduced or absent expression of cd18 on the surface of leukocytes which impairs their ability to migrate and interact with antigens. initial clinical signs include omphalitis and delayed separation of the umbilical cord. the clinical course is marked by recurrent bacterial and fungal infection without pus formation. in instances where there is < 1% expression of cd18, prognosis is dismal with a high likelihood for life-threatening infection within the first year of life.
  • Leukocyte Adhesion Deficiency Type 2|CDGIIc|Congenital Disorder of Glycosylation Type IIc|LAD-Type II|Sialyl-Lewis X Defect

    leukocyte adhesion deficiency, type ii. an inherited disease affecting the metabolism of fucose, which affects the expression of the sialyl lewis x antigen, the fucose-containing ligand for e- and p-selectins, resulting in a deficiency in neutrophil adhesion. syn sialyl-lewis x defect.
  • Leukocyte Adhesion Deficiency Type 3|LAD-3|LAD-III

    an autosomal recessive condition caused by mutation(s) in the fermt3 gene, encoding fermitin family homolog 3. it is characterized by a defect in activation of all beta integrins. it manifests clinically as severe infections with marked leukocytosis, accompanied by life-threatening bleeding episodes.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Alder (granulation) (granulocyte) anomaly
  • Alder syndrome
  • Hereditary leukocytic hypersegmentation
  • Hereditary leukocytic hyposegmentation
  • Hereditary leukomelanopathy
  • May-Hegglin (granulation) (granulocyte) anomaly
  • May-Hegglin syndrome
  • Pelger-Huët (granulation) (granulocyte) anomaly
  • Pelger-Huët syndrome

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Chédiak -Steinbrinck-Higashi syndrome E70.330

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert D72.0 to ICD-9-CM

  • ICD-9-CM Code: 288.2 - Genetic anomaly leukocyt

Patient Education

Blood Disorders

Your blood is living tissue made up of liquid and solids. The liquid part, called plasma, is made of water, salts and protein. Over half of your blood is plasma. The solid part of your blood contains red blood cells, white blood cells and platelets.

Blood disorders affect one or more parts of the blood and prevent your blood from doing its job. They can be acute or chronic. Many blood disorders are inherited. Other causes include other diseases, side effects of medicines, and a lack of certain nutrients in your diet.

Types of blood disorders include:

  • Platelet disorders, excessive clotting, and bleeding problems, which affect how your blood clots
  • Anemia, which happens when your blood does not carry enough oxygen to the rest of your body
  • Cancers of the blood, such as leukemia and myeloma
  • Eosinophilic disorders, which are problems with one type of white blood cell.

[Learn More in MedlinePlus]

Genetic Disorders

Genes are the building blocks of heredity. They are passed from parent to child. They hold DNA, the instructions for making proteins. Proteins do most of the work in cells. They move molecules from one place to another, build structures, break down toxins, and do many other maintenance jobs.

Sometimes there is a mutation, a change in a gene or genes. The mutation changes the gene's instructions for making a protein, so the protein does not work properly or is missing entirely. This can cause a medical condition called a genetic disorder.

You can inherit a gene mutation from one or both parents. A mutation can also happen during your lifetime.

There are three types of genetic disorders:

  • Single-gene disorders, where a mutation affects one gene. Sickle cell anemia is an example.
  • Chromosomal disorders, where chromosomes (or parts of chromosomes) are missing or changed. Chromosomes are the structures that hold our genes. Down syndrome is a chromosomal disorder.
  • Complex disorders, where there are mutations in two or more genes. Often your lifestyle and environment also play a role. Colon cancer is an example.

Genetic tests on blood and other tissue can identify genetic disorders.

NIH: National Library of Medicine

[Learn More in MedlinePlus]

MYH9-related disorder

MYH9-related disorder is a condition that can have many signs and symptoms, including bleeding problems, hearing loss, kidney (renal) disease, and clouding of the lens of the eyes (cataracts).

The bleeding problems in people with MYH9-related disorder are due to thrombocytopenia. Thrombocytopenia is a reduced level of circulating platelets, which are small cells that normally assist with blood clotting. People with MYH9-related disorder typically experience easy bruising, and affected women have excessive bleeding during menstruation (menorrhagia). The platelets in people with MYH9-related disorder are larger than normal. These enlarged platelets have difficulty moving into tiny blood vessels like capillaries. As a result, the platelet level is even lower in these small vessels, further impairing clotting.

Some people with MYH9-related disorder develop hearing loss caused by abnormalities of the inner ear (sensorineural hearing loss). Hearing loss may be present from birth or can develop anytime into late adulthood.

An estimated 30 to 70 percent of people with MYH9-related disorder develop renal disease, usually beginning in early adulthood. The first sign of renal disease in MYH9-related disorder is typically protein or blood in the urine. Renal disease in these individuals particularly affects structures called glomeruli, which are clusters of tiny blood vessels that help filter waste products from the blood. The resulting damage to the kidneys can lead to kidney failure and end-stage renal disease (ESRD).

Some affected individuals develop cataracts in early adulthood that worsen over time.

Not everyone with MYH9-related disorder has all of the major features. All individuals with MYH9-related disorder have thrombocytopenia and enlarged platelets. Most commonly, affected individuals will also have hearing loss and renal disease. Cataracts are the least common sign of this disorder.

MYH9-related disorder was previously thought to be four separate disorders: May-Hegglin anomaly, Epstein syndrome, Fechtner syndrome, and Sebastian syndrome. All of these disorders involved thrombocytopenia and enlarged platelets and were distinguished by some combination of hearing loss, renal disease, and cataracts. When it was discovered that these four conditions all had the same genetic cause, they were combined and renamed MYH9-related disorder.

[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.


[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.