D59.3 - Hemolytic-uremic syndrome

Version 2023
Replaced Code
ICD-10:D59.3
Short Description:Hemolytic-uremic syndrome
Long Description:Hemolytic-uremic syndrome
Status: Not Valid for Submission
Version:ICD-10-CM 2023
Code Classification:
  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
    • Hemolytic anemias (D55-D59)
      • Acquired hemolytic anemia (D59)

D59.3 is a non-specific and non-billable ICD-10 code code, consider using a code with a higher level of specificity for a diagnosis of hemolytic-uremic syndrome. The code is not specific and is NOT valid for the year 2023 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Clinical Information

Specific Coding for Hemolytic-uremic syndrome

Non-specific codes like D59.3 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10 codes with a higher level of specificity when coding for hemolytic-uremic syndrome:

  • BILLABLE CODE - Use D59.30 for Hemolytic-uremic syndrome, unspecified
  • BILLABLE CODE - Use D59.31 for Infection-associated hemolytic-uremic syndrome
  • BILLABLE CODE - Use D59.32 for Hereditary hemolytic-uremic syndrome
  • BILLABLE CODE - Use D59.39 for Other hemolytic-uremic syndrome

New 2023 ICD-10 Code

D59.3 is new to ICD-10 code set for the FY 2023, effective October 1, 2022. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2022. This is a new and revised code for the FY 2023 (October 1, 2022 - September 30, 2023).

Replaced Code

This code was replaced in the 2023 ICD-10 code set with the code(s) listed below. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2022. This code was replaced for the FY 2023 (October 1, 2022 - September 30, 2023).


  • D59.30 - Hemolytic-uremic syndrome, unspecified
  • D59.31 - Infection-associated hemolytic-uremic syndrome
  • D59.32 - Hereditary hemolytic-uremic syndrome
  • D59.39 - Other hemolytic-uremic syndrome

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more. The following references are applicable to this diagnosis code:


Code Also

Code Also
A "code also" note instructs that two codes may be required to fully describe a condition, but this note does not provide sequencing direction.

Convert to ICD-9 Code

Source ICD-10 CodeTarget ICD-9 Code
D59.3283.11 - Hemolytic uremic synd

Patient Education


Kidney Diseases

You have two kidneys, each about the size of your fist. They are near the middle of your back, just below the rib cage. Inside each kidney there are about a million tiny structures called nephrons. They filter your blood. They remove wastes and extra water, which become urine. The urine flows through tubes called ureters. It goes to your bladder, which stores the urine until you go to the bathroom.

Most kidney diseases attack the nephrons. This damage may leave kidneys unable to remove wastes. Causes can include genetic problems, injuries, or medicines. You have a higher risk of kidney disease if you have diabetes, high blood pressure, or a close family member with kidney disease. Chronic kidney disease damages the nephrons slowly over several years. Other kidney problems include:

Your doctor can do blood and urine tests to check if you have kidney disease. If your kidneys fail, you will need dialysis or a kidney transplant.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases


[Learn More in MedlinePlus]

Platelet Disorders

Platelets, also known as thrombocytes, are blood cells. They form in your bone marrow, a sponge-like tissue in your bones. Platelets play a major role in blood clotting. Normally, when one of your blood vessels is injured, you start to bleed. Your platelets will clot (clump together) to plug the hole in the blood vessel and stop the bleeding. You can have different problems with your platelets:

NIH: National Heart, Lung, and Blood Institute


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Atypical hemolytic-uremic syndrome

Atypical hemolytic-uremic syndrome is a disease that primarily affects kidney function. This condition, which can occur at any age, causes abnormal blood clots (thrombi) to form in small blood vessels in the kidneys. These clots can cause serious medical problems if they restrict or block blood flow. Atypical hemolytic-uremic syndrome is characterized by three major features related to abnormal clotting: hemolytic anemia, thrombocytopenia, and kidney failure.

Hemolytic anemia occurs when red blood cells break down (undergo hemolysis) prematurely. In atypical hemolytic-uremic syndrome, red blood cells can break apart as they squeeze past clots within small blood vessels. Anemia results if these cells are destroyed faster than the body can replace them. Anemia can lead to unusually pale skin (pallor), yellowing of the eyes and skin (jaundice), fatigue, shortness of breath, and a rapid heart rate.

Thrombocytopenia is a reduced level of circulating platelets, which are cells that normally assist with blood clotting. In people with atypical hemolytic-uremic syndrome, fewer platelets are available in the bloodstream because a large number of platelets are used to make abnormal clots. Thrombocytopenia can cause easy bruising and abnormal bleeding.

As a result of clot formation in small blood vessels, people with atypical hemolytic-uremic syndrome experience kidney damage and acute kidney failure that lead to end-stage renal disease (ESRD) in about half of all cases. These life-threatening complications prevent the kidneys from filtering fluids and waste products from the body effectively.

Atypical hemolytic-uremic syndrome should be distinguished from a more common condition called typical hemolytic-uremic syndrome. The two disorders have different causes and different signs and symptoms. Unlike the atypical form, the typical form is caused by infection with certain strains of Escherichia coli bacteria that produce toxic substances called Shiga-like toxins. The typical form is characterized by severe diarrhea and most often affects children younger than 10. The typical form is less likely than the atypical form to involve recurrent attacks of kidney damage that lead to ESRD.


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Code History