ICD-10-CM Code M35.9

Systemic involvement of connective tissue, unspecified

Version 2020 Billable Code

Valid for Submission

M35.9 is a billable code used to specify a medical diagnosis of systemic involvement of connective tissue, unspecified. The code is valid for the year 2020 for the submission of HIPAA-covered transactions. The ICD-10-CM code M35.9 might also be used to specify conditions or terms like acquired poikiloderma, acquired sensorineural hearing loss, associated pulmonary arterial hypertension, autoimmune connective tissue disorder, autoimmune disease, autoimmune inflammation of skeletal muscle, etc

Short Description:Systemic involvement of connective tissue, unspecified
Long Description:Systemic involvement of connective tissue, unspecified

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code M35.9:

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Autoimmune disease (systemic) NOS
  • Collagen (vascular) disease NOS

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code M35.9 are found in the index:


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Acquired poikiloderma
  • Acquired sensorineural hearing loss
  • Associated pulmonary arterial hypertension
  • Autoimmune connective tissue disorder
  • Autoimmune disease
  • Autoimmune inflammation of skeletal muscle
  • Autoimmune leukopenia
  • Autoimmune necrotizing myopathy
  • Autoimmune pancytopenia
  • Autoimmune sensorineural hearing loss
  • Autoimmune skin disease
  • Collagen and elastic tissue disorders affecting skin
  • Collagen disease
  • Congenital connective tissue disorder
  • Conjunctivitis associated with autoimmune skin disorder
  • Connective tissue disease overlap syndrome
  • Connective tissue hereditary disorder
  • Dilated cardiomyopathy associated with connective tissue disorder
  • Disorder of connective tissue co-occurrent and due to systemic disease
  • Disseminated eosinophilic collagen disease
  • Idiopathic inflammatory myopathy
  • Immune neutropenia
  • Interstitial lung disease due to collagen vascular disease
  • Interstitial lung disease due to connective tissue disease
  • Lung disease due to connective tissue disorder
  • Lung disorder due to autoimmune disorder
  • Metabolic disease of collagen
  • Mixed collagen vascular disease
  • Necrotizing vasculitis secondary to connective tissue disease
  • Neutropenia associated with autoimmune disease
  • Overlap syndrome
  • Pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection
  • Pericarditis secondary to collagen vascular disease
  • Photodermatitis co-occurrent and due to autoimmune disease
  • Poikiloderma due to connective tissue disease
  • Polymyositis
  • Polymyositis associated with autoimmune disease
  • Polyneuropathy co-occurrent and due to systemic connective tissue disorder
  • Polyneuropathy in collagen vascular disease
  • Pulmonary arterial hypertension associated with connective tissue disease
  • Renal tubulo-interstitial disorders in systemic connective tissue disorders
  • Xerostomia
  • Xerostomia due to autoimmune disease

Diagnostic Related Groups

The ICD-10 code M35.9 is grouped in the following groups for version MS-DRG V37.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2019 through 09/30/2020.


Convert M35.9 to ICD-9

  • 710.9 - Diff connect tis dis NOS (Approximate Flag)

Code Classification

  • Diseases of the musculoskeletal system and connective tissue (M00–M99)
    • Systemic connective tissue disorders (M30-M36)
      • Other systemic involvement of connective tissue (M35)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients

Connective Tissue Disorders

Your connective tissue supports many different parts of your body, such as your skin, eyes, and heart. It is like a "cellular glue" that gives your body parts their shape and helps keep them strong. It also helps some of your tissues do their work. It is made of many kinds of proteins. Cartilage and fat are types of connective tissue.

Over 200 disorders that impact connective tissue. There are different types:

  • Genetic disorders, such as Ehlers-Danlos syndrome, Marfan syndrome, and osteogenesis imperfecta
  • Autoimmune disorders, such as lupus and scleroderma
  • Cancers, like some types of soft tissue sarcoma

Each disorder has its own symptoms and needs different treatment.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

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