2024 ICD-10-CM Diagnosis Code D66

Hereditary factor VIII deficiency

ICD-10-CM Code:
ICD-10 Code for:
Hereditary factor VIII deficiency
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Code Navigator:

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
    • Coagulation defects, purpura and other hemorrhagic conditions
      • Hereditary factor VIII deficiency

D66 is a billable diagnosis code used to specify a medical diagnosis of hereditary factor viii deficiency. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Combined deficiency of factor V and factor VIII
  • Factor V deficiency
  • Factor VIII deficiency
  • Hemophilia
  • Hereditary combined coagulation factor deficiency
  • Hereditary factor VIII deficiency disease
  • Hereditary factor VIII deficiency disease with inhibitor
  • Hereditary factor VIII deficiency disease without inhibitor
  • Lamellar ichthyosis
  • Mild hereditary factor VIII deficiency disease
  • Mild hereditary factor VIII deficiency disease with inhibitor
  • Mild hereditary factor VIII deficiency disease without inhibitor
  • Moderate hereditary factor VIII deficiency disease
  • Moderate hereditary factor VIII deficiency disease with inhibitor
  • Moderate hereditary factor VIII deficiency disease without inhibitor
  • Multiple sclerosis, ichthyosis, factor VIII deficiency syndrome
  • Severe hereditary factor VIII deficiency disease
  • Severe hereditary factor VIII deficiency disease with inhibitor
  • Severe hereditary factor VIII deficiency disease without inhibitor

Clinical Classification

Clinical Information

  • Factor V Deficiency

    a deficiency of blood coagulation factor v (known as proaccelerin or accelerator globulin or labile factor) leading to a rare hemorrhagic tendency known as owren's disease or parahemophilia. it varies greatly in severity. factor v deficiency is an autosomal recessive trait. (dorland, 27th ed)
  • ABCA12 wt Allele|ABC12|ARCI4A|ARCI4B|ATP Binding Cassette Subfamily A Member 12 wt Allele|ATP-Binding Cassette, Sub-Family A (ABC1), Member 12 Gene|ATP-Binding Cassette, Subfamily A, Member 12 Gene|DKFZP434G232|ICR2B|Ichthyosis Congenita II, Lamellar Ichthyosis B Gene|LI2

    human abca12 wild-type allele is located in the vicinity of 2q35 and is approximately 207 kb in length. this allele, which encodes glucosylceramide transporter abca12 protein, plays a role in both the membrane localization of glucosylceramide and other lipids in lamellar granules and in cholesterol transport. mutation of the gene is associated with autosomal recessive congenital ichthyosis (arci) types 4a and 4b (harlequin).
  • Lamellar Ichthyosis

    a very rare, autosomal recessive inherited skin disorder present at birth. it is characterized by the presence of a transparent membrane encasing the newborn. this membrane sheds in about two weeks after birth to reveal generalized scaling and skin erythema.
  • Acquired Factor V Deficiency

    an acquired coagulation disorder characterized by the partial or complete absence of factor v activity in the blood.
  • Factor V Deficiency

    a coagulation disorder characterized by the partial or complete absence of factor v activity in the blood.
  • Hereditary Factor V Deficiency|Owren Disease

    a very rare autosomal recessive inherited blood coagulation disorder characterized by deficiency of factor v, resulting in bleeding.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Classical hemophilia
  • Deficiency factor VIII (with functional defect)
  • Hemophilia NOS
  • Hemophilia A

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • factor VIII deficiency with vascular defect D68.0

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert D66 to ICD-9-CM

  • ICD-9-CM Code: 286.0 - Cong factor viii diord

Patient Education


What is hemophilia?

Hemophilia is a rare bleeding disorder in which the blood does not clot properly. This can lead to problems with bleeding too much after an injury or surgery. You can also have sudden bleeding inside your body, such as in your joints, muscles, and organs.

Your blood contains many proteins called clotting factors that can help form clots to stop bleeding. People with hemophilia have low levels of one of these factors, usually either factor VIII (8) or factor IX (9). How severe the hemophilia is depends on the amount of factor in the blood. The lower the amount of the factor, the more likely it is that bleeding could happen and might lead to serious health problems.

What are the types of hemophilia?

There are several different types of hemophilia. The most common are:

  • Hemophilia A (classic hemophilia), which is caused by a lack or decrease of clotting factor VIII (8)
  • Hemophilia B (Christmas disease), which is caused by a lack or decrease of clotting factor IX (9)

What causes hemophilia?

Most types of hemophilia are inherited. They are caused by change in one of the genes (also called a mutation) that provides instructions for making the clotting factor proteins. The change may mean that the clotting proteins don't work properly or that they are missing altogether.

These genes are on the X chromosome. You may have one or two X chromosomes:

  • People who are born male have one X chromosome (from the mother) and one Y chromosome (from the father). They can get hemophilia if their one X chromosome has the gene change.
  • People who are born female have two X chromosomes, one from the father and one from the mother. They usually only get hemophilia if:
    • Both X chromosomes have the gene change OR
    • One X chromosome has the gene change and the other X chromosome is missing or inactive.

    People who are born female who have the gene change on one X chromosome are a "carrier" of hemophilia. Sometimes they may have some symptoms of hemophilia. They can pass the gene change on to their children.

Hemophilia that is not inherited is called acquired hemophilia. It is rare. It happens when your body makes specialized proteins called autoantibodies that attack and disable a clotting factor. This can happen because of pregnancy, immune system disorders, cancer, or allergic reactions to certain medicines. Sometimes the cause is unknown.

Who is at risk for hemophilia?

Hemophilia is much more common in people who were born male since they can get it with a change to the gene on one X chromosome. People who have a family history of hemophilia are also at higher risk.

What are the symptoms of hemophilia?

The signs and symptoms of hemophilia are:

  • Bleeding into the joints. This can cause swelling and pain or tightness in the joints. It often affects the knees, elbows, and ankles.
  • Bleeding into the skin (which is bruising).
  • Bleeding into the muscle and soft tissue, which can cause a build-up of blood in the area (called a hematoma).
  • Bleeding of the mouth and gums, including bleeding that is hard to stop after you lose a tooth.
  • Bleeding after circumcision.
  • Bleeding after having shots, such as vaccinations.
  • Bleeding in the head of an infant after a difficult delivery.
  • Blood in the urine or stool.
  • Frequent and hard-to-stop nosebleeds.

In some cases, severe hemophilia may cause bleeding in the brain. This may cause brain damage and can be life-threatening.

How is hemophilia diagnosed?

To find out if you have hemophilia, your health care provider will:

  • Ask about your medical history, including your symptoms and other health conditions you may have.
  • Ask about your family history, to find out if you have relatives who have or had hemophilia.
  • Do a physical exam to look for signs of hemophilia, such as bruising.
  • Do certain blood tests to show if your blood is clotting properly. If it does not, then you will have clotting factor tests to diagnose the cause of the bleeding disorder. These blood tests would show the type of hemophilia and the severity.

There is genetic testing for the factor VIII (8) and factor IX (9) genes. This testing may be used in people who have a family history of hemophilia to:

  • Identify people who are carriers before they make decisions about pregnancy
  • Test a fetus for hemophilia during pregnancy
  • Test a newborn for hemophilia

What are the treatments for hemophilia?

The best way to treat hemophilia is to replace the missing clotting factor so that your blood can clot properly. This is usually done by injecting replacement clotting factor into a vein. The replacement clotting factor may be made from donated human blood. Or it may be made in a lab; this kind is called a recombinant clotting factor.

Replacement clotting factor can help treat a bleeding episode. In more severe cases of hemophilia, you might get the factor on a regular basis to prevent bleeding. You can learn how to inject the factor so that you can do it yourself at home.

There are other medicines to treat hemophilia. They may work by releasing factor VIII (8) from where it is stored in the body tissues, replacing the function of factor VIII (8), or preventing clots from breaking down.

If bleeding has damaged your joints, physical therapy may help them function better.

Good quality medical care from healthcare professionals who know a lot about the disorder can help prevent some serious problems. Often the best choice for care is to visit a hemophilia treatment center (HTC).

Centers for Disease Control and Prevention

[Learn More in MedlinePlus]


Hemophilia is a bleeding disorder that slows the blood clotting process. People with this condition experience prolonged bleeding or oozing following an injury, surgery, or having a tooth pulled. In severe cases of hemophilia, continuous bleeding occurs after minor trauma or even when there is no obvious injury (sometimes called spontaneous bleeding). Serious complications can result from bleeding into the joints, muscles, brain, or other internal organs. Milder forms of hemophilia do not necessarily involve spontaneous bleeding, and the condition may not become apparent until abnormal bleeding occurs following surgery or a serious injury.

The major types of this condition are hemophilia A (also known as classic hemophilia or factor VIII deficiency) and hemophilia B (also known as Christmas disease or factor IX deficiency). Although the two types have very similar signs and symptoms, they are caused by variants (also known as mutations) in different genes. People with an unusual form of hemophilia B, known as hemophilia B Leyden, experience episodes of excessive bleeding in childhood but have few bleeding problems after puberty.

[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.


[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.