2027 ICD-10-CM Diagnosis Code D57Sickle-cell disorders

ICD-10-CM Codes›D50–D89›D55-D59›D57

ICD-10-CM D57
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

D57 is a non-billable ICD-10-CM category code for sickle-cell disorders, so it cannot be submitted on claims. Use a more specific code from this category instead, such as D57.00, D57.01, D57.02, and D57.03.

Code Identity

ICD-10-CM Code
D57
Billable Status
No — Non-Billable Category
Code Describes
Sickle-cell disorders
Short Description
Sickle-cell disorders
Same as the full description in the CMS dataset.
Chapter
D55-D59
Hemolytic anemias

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD55-D59Hemolytic anemias
CategoryD57Sickle-cell disorders
This CodeD57Sickle-cell disorders

Specific Coding for Sickle-cell disordersOverview

Non-specific codes like D57 require more characters. Use one of these billable codes instead:

  • D57.0 for Hb-SS disease with crisis

  • Use D57.00 for Hb-SS disease with crisis, unspecified

  • Use D57.01 for Hb-SS disease with acute chest syndrome

  • Use D57.02 for Hb-SS disease with splenic sequestration

  • Use D57.03 for Hb-SS disease with cerebral vascular involvement

  • Use D57.04 for Hb-SS disease with dactylitis

  • Use D57.09 for Hb-SS disease with crisis with other specified complication

  • Use D57.1 for Sickle-cell disease without crisis

  • D57.2 for Sickle-cell/Hb-C disease

  • Use D57.20 for Sickle-cell/Hb-C disease without crisis

  • D57.21 for Sickle-cell/Hb-C disease with crisis

  • Use D57.3 for Sickle-cell trait

  • D57.4 for Sickle-cell thalassemia

  • Use D57.40 for Sickle-cell thalassemia without crisis

  • D57.41 for Sickle-cell thalassemia, unspecified, with crisis

  • Use D57.42 for Sickle-cell thalassemia beta zero without crisis

  • D57.43 for Sickle-cell thalassemia beta zero with crisis

  • Use D57.44 for Sickle-cell thalassemia beta plus without crisis

  • D57.45 for Sickle-cell thalassemia beta plus with crisis

  • D57.8 for Other sickle-cell disorders

  • Use D57.80 for Other sickle-cell disorders without crisis

  • D57.81 for Other sickle-cell disorders with crisis

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to D57: its own notes plus those printed at Chapter 3. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

  • other hemoglobinopathies (D58.-)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Chapter 3 (D50-D89) Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism applies to 324 codes
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

  • code for any associated fever (R50.81)

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name D57, its category, or a range that includes it.

Excludes1 2

These codes carry an Excludes1 note naming D57: they are not reported together with it, unless the two conditions are unrelated.

  • D56.8 Other thalassemias
    sickle-cell anemia (D57.-)
  • Block P50-P61 Hemorrhagic and hematological disorders of newborn
    hereditary hemolytic anemias (D55-D58) names D55-D58, which includes this code

Code First 3

These codes say to code first a condition named in the note, and D57 is one of the conditions named.

  • H36 Retinal disorders in diseases classified elsewhere
    sickle-cell disorders (D57.-)
  • M14.8 Arthropathies in other specified diseases classified elsewhere
    sickle-cell disorders (D57.-)
  • R50.81 Fever presenting with conditions classified elsewhere
    sickle-cell disease (D57.-)

Code Also 1

These codes say D57 may also be needed to fully describe the condition. The note gives no sequencing direction.

  • Z71.87 Encounter for pediatric-to-adult transition counseling
    sickle-cell disorder (D57.-)

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical InformationClinical

  • Anemia, Sickle Cell

    a disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. it is the clinical expression of homozygosity for hemoglobin s.

Patient EducationClinical

Sickle Cell Disease

Sickle cell disease (SCD) is a group of inherited red blood cell disorders. If you have SCD, there is a problem with your hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. With SCD, the hemoglobin forms into stiff rods within the red blood cells. This changes the shape of the red blood cells.

The full article covers:

  • What is sickle cell disease (SCD)?
  • What causes sickle cell disease (SCD)?
  • Who is more likely to have sickle cell disease (SCD)?
  • What are the symptoms of sickle cell disease (SCD)?
  • How is sickle cell disease (SCD) diagnosed?
  • What are the treatments for sickle cell disease (SCD)?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About D57Overview

What is the ICD-10 code for sickle-cell disorders?

D57 is the ICD-10-CM category for sickle-cell disorders, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is D57 (Sickle-cell disorders) a billable code?

No. This is a category header that groups the codes for sickle-cell disorders, and headers cannot be submitted on claims. Claims for sickle-cell disorders need a more specific code from this category, such as D57.00, D57.01, and D57.02.

Can D57 be reported with a code from D58?

Not as a rule. The Excludes1 note on D57 lists "other hemoglobinopathies (D58.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does D57 need an additional code?

When the condition applies, yes. The Use Additional Code note reads: code for any associated fever (R50.81). The additional code is reported after D57.