2026 ICD-10-CM Diagnosis Code D57Sickle-cell disorders

ICD-10-CM Codes›D50–D89›D55-D59›D57

ICD-10-CM D57
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D57 is a non-billable ICD-10-CM category code for sickle-cell disorders, so it cannot be submitted on claims. Use a more specific code from this category instead, such as D57.00, D57.01, D57.02, and D57.03.

Code Identity

ICD-10-CM Code
D57
Billable Status
No — Non-Billable Category
Code Describes
Sickle-cell disorders
Chapter
D55-D59
Hemolytic anemias

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD55-D59Hemolytic anemias
CategoryD57Sickle-cell disorders
This CodeD57Sickle-cell disorders

Specific Coding for Sickle-cell disordersOverview

Non-specific codes like D57 require more characters. Use one of these billable codes instead:

  • D57.0 for Hb-SS disease with crisis

  • Use D57.00 for Hb-SS disease with crisis, unspecified

  • Use D57.01 for Hb-SS disease with acute chest syndrome

  • Use D57.02 for Hb-SS disease with splenic sequestration

  • Use D57.03 for Hb-SS disease with cerebral vascular involvement

  • Use D57.04 for Hb-SS disease with dactylitis

  • Use D57.09 for Hb-SS disease with crisis with other specified complication

  • Use D57.1 for Sickle-cell disease without crisis

  • D57.2 for Sickle-cell/Hb-C disease

  • Use D57.20 for Sickle-cell/Hb-C disease without crisis

  • D57.21 for Sickle-cell/Hb-C disease with crisis

  • Use D57.3 for Sickle-cell trait

  • D57.4 for Sickle-cell thalassemia

  • Use D57.40 for Sickle-cell thalassemia without crisis

  • D57.41 for Sickle-cell thalassemia, unspecified, with crisis

  • Use D57.42 for Sickle-cell thalassemia beta zero without crisis

  • D57.43 for Sickle-cell thalassemia beta zero with crisis

  • Use D57.44 for Sickle-cell thalassemia beta plus without crisis

  • D57.45 for Sickle-cell thalassemia beta plus with crisis

  • D57.8 for Other sickle-cell disorders

  • Use D57.80 for Other sickle-cell disorders without crisis

  • D57.81 for Other sickle-cell disorders with crisis

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Use Additional Code

  • code for any associated fever R50.81

Type 1 Excludes

  • other hemoglobinopathies D58

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Arthropathy
      • gouty
        • in (due to)
          • sickle-cell disorders

Patient EducationClinical

Sickle Cell Disease

Sickle cell disease (SCD) is a group of inherited red blood cell disorders. If you have SCD, there is a problem with your hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. With SCD, the hemoglobin forms into stiff rods within the red blood cells. This changes the shape of the red blood cells.

The full article covers:

  • What is sickle cell disease (SCD)?
  • What causes sickle cell disease (SCD)?
  • Who is more likely to have sickle cell disease (SCD)?
  • What are the symptoms of sickle cell disease (SCD)?
  • How is sickle cell disease (SCD) diagnosed?
  • What are the treatments for sickle cell disease (SCD)?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D57Overview

Is D57 (Sickle-cell disorders) a billable code?

No. This is a category header that groups the codes for sickle-cell disorders, and headers cannot be submitted on claims. Claims for sickle-cell disorders need a more specific code from this category, such as D57.00, D57.01, and D57.02.