ICD-10-CM Code D59.5

Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]

Version 2021 Billable Code

Valid for Submission

D59.5 is a billable code used to specify a medical diagnosis of paroxysmal nocturnal hemoglobinuria [marchiafava-micheli]. The code is valid for the fiscal year 2021 for the submission of HIPAA-covered transactions. The ICD-10-CM code D59.5 might also be used to specify conditions or terms like paroxysmal nocturnal hemoglobinuria or thrombophilia due to paroxysmal nocturnal hemoglobinuria.

ICD-10:D59.5
Short Description:Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
Long Description:Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code D59.5:

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • hemoglobinuria NOS R82.3

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code D59.5 are found in the index:


Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Paroxysmal nocturnal hemoglobinuria
  • Thrombophilia due to paroxysmal nocturnal hemoglobinuria

Clinical Information

  • HEMOGLOBINURIA PAROXYSMAL-. a condition characterized by the recurrence of hemoglobinuria caused by intravascular hemolysis. in cases occurring upon cold exposure paroxysmal cold hemoglobinuria usually after infections there is a circulating antibody which is also a cold hemolysin. in cases occurring during or after sleep paroxysmal nocturnal hemoglobinuria the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.

Convert D59.5 to ICD-9

  • 283.2 - Hemolytic hemoglobinuria (Approximate Flag)

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
    • Hemolytic anemias (D55-D59)
      • Acquired hemolytic anemia (D59)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients


Anemia

Also called: Iron poor blood

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Anemia has three main causes: blood loss, lack of red blood cell production, and high rates of red blood cell destruction.

Conditions that may lead to anemia include

  • Heavy periods
  • Pregnancy
  • Ulcers
  • Colon polyps or colon cancer
  • Inherited disorders
  • A diet that does not have enough iron, folic acid or vitamin B12
  • Blood disorders such as sickle cell anemia and thalassemia, or cancer
  • Aplastic anemia, a condition that can be inherited or acquired
  • G6PD deficiency, a metabolic disorder

Anemia can make you feel tired, cold, dizzy, and irritable. You may be short of breath or have a headache.

Your doctor will diagnose anemia with a physical exam and blood tests. Treatment depends on the kind of anemia you have.

NIH: National Heart, Lung, and Blood Institute

  • Anemia (Medical Encyclopedia)
  • Anemia - B12 deficiency (Medical Encyclopedia)
  • Anemia caused by low iron -- infants and toddlers (Medical Encyclopedia)
  • Anemia of chronic disease (Medical Encyclopedia)
  • Anemia of Inflammation and Chronic Disease - NIH
  • Febrile/cold agglutinins (Medical Encyclopedia)
  • Ferritin blood test (Medical Encyclopedia)
  • Hemolytic anemia (Medical Encyclopedia)
  • Iron deficiency anemia (Medical Encyclopedia)
  • Pernicious anemia (Medical Encyclopedia)
  • Vitamin B12 level (Medical Encyclopedia)

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Urine and Urination

Your kidneys make urine by filtering wastes and extra water from your blood. The waste is called urea. Your blood carries it to the kidneys. From the kidneys, urine travels down two thin tubes called ureters to the bladder. The bladder stores urine until you are ready to urinate. It swells into a round shape when it is full and gets smaller when empty. If your urinary system is healthy, your bladder can hold up to 16 ounces (2 cups) of urine comfortably for 2 to 5 hours.

You may have problems with urination if you have

  • Kidney failure
  • Urinary tract infections
  • An enlarged prostate
  • Bladder control problems like incontinence, overactive bladder, or interstitial cystitis
  • A blockage that prevents you from emptying your bladder

Some conditions may also cause you to have blood or protein in your urine. If you have a urinary problem, see your health care provider. Urinalysis and other urine tests can help to diagnose the problem. Treatment depends on the cause.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

  • Clean catch urine sample (Medical Encyclopedia)
  • Frequent or urgent urination (Medical Encyclopedia)
  • RBC urine test (Medical Encyclopedia)
  • Urinalysis (Medical Encyclopedia)
  • Urinary catheters (Medical Encyclopedia)
  • Urinary Retention - NIH (National Institute of Diabetes and Digestive and Kidney Diseases)
  • Urinating more at night (Medical Encyclopedia)
  • Urination - difficulty with flow (Medical Encyclopedia)
  • Urination - painful (Medical Encyclopedia)
  • Urine - bloody (Medical Encyclopedia)
  • Urine 24-hour volume (Medical Encyclopedia)
  • Urine odor (Medical Encyclopedia)

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Paroxysmal nocturnal hemoglobinuria Paroxysmal nocturnal hemoglobinuria is an acquired disorder that leads to the premature death and impaired production of blood cells. The disorder affects red blood cells (erythrocytes), which carry oxygen; white blood cells (leukocytes), which protect the body from infection; and platelets (thrombocytes), which are involved in blood clotting. Paroxysmal nocturnal hemoglobinuria affects both sexes equally, and can occur at any age, although it is most often diagnosed in young adulthood.People with paroxysmal nocturnal hemoglobinuria have sudden, recurring episodes of symptoms (paroxysmal symptoms), which may be triggered by stresses on the body, such as infections or physical exertion. During these episodes, red blood cells are prematurely destroyed (hemolysis). Affected individuals may pass dark-colored urine due to the presence of hemoglobin, the oxygen-carrying protein in blood. The abnormal presence of hemoglobin in the urine is called hemoglobinuria. In many, but not all cases, hemoglobinuria is most noticeable in the morning, upon passing urine that has accumulated in the bladder during the night (nocturnal).The premature destruction of red blood cells results in a deficiency of these cells in the blood (hemolytic anemia), which can cause signs and symptoms such as fatigue, weakness, abnormally pale skin (pallor), shortness of breath, and an increased heart rate. People with paroxysmal nocturnal hemoglobinuria may also be prone to infections due to a deficiency of white blood cells.Abnormal platelets associated with paroxysmal nocturnal hemoglobinuria can cause problems in the blood clotting process. As a result, people with this disorder may experience abnormal blood clotting (thrombosis), especially in large abdominal veins; or, less often, episodes of severe bleeding (hemorrhage).Individuals with paroxysmal nocturnal hemoglobinuria are at increased risk of developing cancer in blood-forming cells (leukemia).In some cases, people who have been treated for another blood disease called aplastic anemia may develop paroxysmal nocturnal hemoglobinuria.
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