2024 ICD-10-CM Diagnosis Code D84.1

Defects in the complement system

ICD-10-CM Code:
D84.1
ICD-10 Code for:
Defects in the complement system
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Chronic
Code Navigator:

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
    (D50–D89)
    • Certain disorders involving the immune mechanism
      (D80-D89)
      • Other immunodeficiencies
        (D84)

D84.1 is a billable diagnosis code used to specify a medical diagnosis of defects in the complement system. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Acquired angioedema due to C1 inhibitor autoantibody
  • Acquired C1 esterase inhibitor deficiency
  • Acquired C1 esterase inhibitor deficiency
  • Alternative pathway deficiency
  • Anaphylotoxin inactivator deficiency
  • Angioedema due to disorder of kinin metabolism
  • Angioedema due to disorder of kinin metabolism
  • Angioedema due to disorder of kinin metabolism
  • Angioedema due to disorder of kinin metabolism
  • Angioedema due to disorder of kinin metabolism
  • Angioedema of gingiva due to deficiency of C1 esterase inhibitor
  • Autoimmune angioedema
  • Autoimmune urticaria and/or angioedema
  • Classical complement pathway abnormality
  • Combined complement 6 and 7 deficiencies
  • Complement 1q beta chain deficiency
  • Complement 1q deficiency
  • Complement 1q dysfunction
  • Complement 1r deficiency
  • Complement 1s deficiency
  • Complement 2 deficiency
  • Complement 4 binding protein deficiency
  • Complement 4 deficiency
  • Complement 4A deficiency
  • Complement 4B deficiency
  • Complement 5 deficiency
  • Complement 5 dysfunction
  • Complement 5a inhibitor deficiency
  • Complement 6 deficiency
  • Complement 7 deficiency
  • Complement 8 alpha-gamma deficiency
  • Complement 8 beta chain deficiency
  • Complement 8 beta chain dysfunction
  • Complement 9 deficiency
  • Complement abnormality
  • Complement component 3 deficiency
  • Complement component 8 deficiency
  • Complement component deficiency
  • Complement deficiency disease
  • Complement receptor 1 deficiency
  • Complement receptor 3 deficiency
  • Complement receptor deficiency
  • Complement regulatory factor defect
  • Coombs negative hemolytic anemia
  • Cutis laxa with complement deficiency
  • Cutis laxa, acquired type
  • Decay accelerating factor deficiency
  • Disorder of complement
  • Edema of oral soft tissues
  • Factor B deficiency
  • Factor D deficiency
  • Factor H deficiency
  • Familial C3B inhibitor deficiency syndrome
  • Gingival edema
  • Glomerular disease due to complement system disorder
  • Hereditary angioedema
  • Hereditary angioedema with C1Inh deficiency
  • Hereditary C1 esterase inhibitor deficiency - deficient factor
  • Hereditary C1 esterase inhibitor deficiency - dysfunctional factor
  • Homologous restriction factor deficiency
  • Immunodeficiency due to MASP-2 deficiency
  • Panniculitis due to immunological disorder
  • Panniculitis with complement deficiency
  • Primary CD59 deficiency
  • Properdin deficiency disease
  • Recurrent bacterial infection
  • Recurrent Neisseria infection due to factor D deficiency
  • Terminal component deficiency

Clinical Classification

Clinical Information

  • Hereditary Angioedema

    autosomal dominant inherited disorder characterized by abnormalities of c1 inhibitor. patients present with swelling of the skin, subcutaneous tissues, and mucosa sites.
  • Hereditary Angioedema Types I and II

    autosomal dominant inherited disorders characterized by abnormalities of c1 inhibitor. patients present with swelling of the skin, subcutaneous tissues, and mucosa sites. in type i hereditary angioedema, the plasma levels of c1 inhibitor are decreased. in type ii hereditary angioedema, the c1 inhibitor is dysfunctional and its plasma levels may be normal or elevated.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • C1 esterase inhibitor C1-INH deficiency

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert D84.1 to ICD-9-CM

  • ICD-9-CM Code: 277.6 - Defic circul enzyme NEC
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.
  • ICD-9-CM Code: 279.8 - Immune mechanism dis NEC
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Patient Education


Immune System and Disorders

What is the immune system?

Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.

When germs such as bacteria or viruses invade your body, they attack and multiply. This is called an infection. The infection causes the disease that makes you sick. Your immune system protects you from the disease by fighting off the germs.

What are the parts of the immune system?

The immune system has many different parts, including:

  • Your skin, which can help prevent germs from getting into the body
  • Mucous membranes, which are the moist, inner linings of some organs and body cavities. They make mucus and other substances which can trap and fight germs.
  • White blood cells, which fight germs
  • Organs and tissues of the lymph system, such as the thymus, spleen, tonsils, lymph nodes, lymph vessels, and bone marrow. They produce, store, and carry white blood cells.

How does the immune system work?

Your immune system defends your body against substances it sees as harmful or foreign. These substances are called antigens. They may be germs such as bacteria and viruses. They might be chemicals or toxins. They could also be cells that are damaged from things like cancer or sunburn.

When your immune system recognizes an antigen, it attacks it. This is called an immune response. Part of this response is to make antibodies. Antibodies are proteins that work to attack, weaken, and destroy antigens. Your body also makes other cells to fight the antigen.

Afterwards, your immune system remembers the antigen. If it sees the antigen again, it can recognize it. It will quickly send out the right antibodies, so in most cases, you don't get sick. This protection against a certain disease is called immunity.

What are the types of immunity?

There are three different types of immunity:

  • Innate immunity is the protection that you are born with. It is your body's first line of defense. It includes barriers such as the skin and mucous membranes. They keep harmful substances from entering the body. It also includes some cells and chemicals which can attack foreign substances.
  • Active immunity, also called adaptive immunity, develops when you are infected with or vaccinated against a foreign substance. Active immunity is usually long-lasting. For many diseases, it can last your entire life.
  • Passive immunity happens when you receive antibodies to a disease instead of making them through your own immune system. For example, newborn babies have antibodies from their mothers. People can also get passive immunity through blood products that contain antibodies. This kind of immunity gives you protection right away. But it only lasts a few weeks or months.

What can go wrong with the immune system?

Sometimes a person may have an immune response even though there is no real threat. This can lead to problems such as allergies, asthma, and autoimmune diseases. If you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake.

Other immune system problems happen when your immune system does not work correctly. These problems include immunodeficiency diseases. If you have an immunodeficiency disease, you get sick more often. Your infections may last longer and can be more serious and harder to treat. They are often genetic disorders.

There are other diseases that can affect your immune system. For example, HIV is a virus that harms your immune system by destroying your white blood cells. If HIV is not treated, it can lead to AIDS (acquired immunodeficiency syndrome). People with AIDS have badly damaged immune systems. They get an increasing number of severe illnesses.


[Learn More in MedlinePlus]

Complement component 8 deficiency

Complement component 8 deficiency is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. Immunodeficiencies are conditions in which the immune system is not able to protect the body effectively from foreign invaders such as bacteria. People with complement component 8 deficiency have a significantly increased risk of recurrent bacterial infections, particularly by a bacterium called Neisseria meningitidis. Infection by this bacterium causes inflammation of the membranes surrounding the brain and spinal cord (meningitis). Although meningitis can be life-threatening, individuals with complement component 8 deficiency are less likely to die from the infection than people in the general population who contract it.

The severity of complement component 8 deficiency varies widely. While some people with this condition experience one or more infections, others do not have any health problems related to the disorder.

There are two types of complement component 8 deficiency, types I and II, classified by their genetic cause. The two types have the same signs and symptoms.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.