2026 ICD-10-CM Diagnosis Code D46Myelodysplastic syndromes

ICD-10-CM Codes›C00–D49›D37-D48›D46

ICD-10-CM D46
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D46 is a non-billable ICD-10-CM category code for myelodysplastic syndromes, so it cannot be submitted on claims. Use a more specific code from this category instead, such as D46.0, D46.1, D46.20, and D46.21.

Code Identity

ICD-10-CM Code
D46
Billable Status
No — Non-Billable Category
Code Describes
Myelodysplastic syndromes
Chapter
D37-D48
Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes

Code Classification

ChapterC00–D49Neoplasms
SectionD37-D48Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes
CategoryD46Myelodysplastic syndromes
This CodeD46Myelodysplastic syndromes

Specific Coding for Myelodysplastic syndromesOverview

Non-specific codes like D46 require more characters. Use one of these billable codes instead:

  • Use D46.0 for Refractory anemia without ring sideroblasts, so stated

  • Use D46.1 for Refractory anemia with ring sideroblasts

  • D46.2 for Refractory anemia with excess of blasts [RAEB]

  • Use D46.20 for Refractory anemia with excess of blasts, unspecified

  • Use D46.21 for Refractory anemia with excess of blasts 1

  • Use D46.22 for Refractory anemia with excess of blasts 2

  • Use D46.4 for Refractory anemia, unspecified

  • Use D46.9 for Myelodysplastic syndrome, unspecified

  • Use D46.A for Refractory cytopenia with multilineage dysplasia

  • Use D46.B for Refractory cytopenia with multilineage dysplasia and ring sideroblasts

  • Use D46.C for Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality

  • Use D46.Z for Other myelodysplastic syndromes

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Use Additional Code

  • code for adverse effect, if applicable, to identify drug T36 T50

Type 2 Excludes

  • drug-induced aplastic anemia D61.1

Clinical InformationClinical

  • Myelodysplastic Syndromes

    clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. they predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into acute myeloid leukemia.

Patient EducationClinical

Myelodysplastic Syndromes

Your bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D46Overview

Is D46 (Myelodysplastic syndromes) a billable code?

No. This is a category header that groups the codes for myelodysplastic syndromes, and headers cannot be submitted on claims. Claims for myelodysplastic syndromes need a more specific code from this category, such as D46.0, D46.1, and D46.20.