Certain disorders involving the immune mechanism (D80-D89) ICD-10-CM
The D80–D89 section covers certain disorders involving the immune mechanism with 100 ICD-10-CM diagnosis codes, of which 83 are billable in fiscal year 2027. The section is organized into the 7 code ranges listed below.
Includes
This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
- human immunodeficiency virus [HIV] disease B20
Code Ranges in This Section 7 ranges · 100 codes
The info icon previews the code ranges inside each row and its instructional notations from the official Tabular List.
About the D80–D89 Code Range
These conditions involve immune deficiencies and other disorders of the immune system. They also include sarcoidosis, an inflammatory disorder that usually affects the lungs but can involve other sites.
The immunodeficiency categories separate antibody defects from combined deficiencies, deficiencies associated with other major defects, and other types. D80 distinguishes hereditary and nonfamilial conditions, specific antibody types, and a temporary condition of infancy. D81 includes combined deficiencies distinguished by cell numbers or named defects. D82 identifies associated major defects. D83 separates common variable immunodeficiency by B-cell, T-cell, or autoantibody findings. D84 includes other immunodeficiencies, such as complement system defects.
D86 organizes sarcoidosis by affected site, including the lung, lymph nodes, and skin. D89 groups other immune-system disorders by condition, including immune reconstitution syndrome and mast cell activation syndrome.
Questions About This Page
How many codes are in the D80-D89 range?
The D80-D89 range contains 100 ICD-10-CM diagnosis codes in FY 2027. 83 of them are billable, and the rest are category headers that organize the section.
What conditions does D80-D89 cover?
The range covers certain disorders involving the immune mechanism. The code ranges listed above break it into groups of related conditions, and each one links to its own page with the full code list.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
