Certain disorders involving the immune mechanism (D80-D89) ICD-10-CM
The D80–D89 section covers certain disorders involving the immune mechanism with 100 ICD-10-CM diagnosis codes, of which 83 are billable in fiscal year 2026. The section is organized into the 7 code ranges listed below.
Includes
This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Code Ranges in This Section 7 ranges · 100 codes
The info icon previews the code ranges inside each row and its instructional notations from the official Tabular List.
About the D80–D89 Code Range
ICD-10 codes D80 through D89 classify various disorders related to the immune system, focusing on immunodeficiencies and immune mechanism abnormalities. These codes are essential for coding diseases such as antibody deficiencies, combined immunodeficiencies, immunodeficiencies with major anatomical defects, sarcoidosis, and other immune dysfunctions.
This range includes D80 codes for immunodeficiencies with antibody defects, covering conditions like hereditary hypogammaglobulinemia and selective immunoglobulin deficiencies (IgA, IgG subclasses, IgM), also known as congenital agammaglobulinemia or humoral immune defects. D81 addresses severe combined immunodeficiencies (SCID) and specific enzyme deficiencies such as adenosine deaminase deficiency. Codes D82 classify immunodeficiencies linked to major physical anomalies, including Wiskott-Aldrich and Di George syndromes. The D83 category includes common variable immunodeficiency types, emphasizing B-cell and T-cell disorders. Other immunodeficiencies without a specified classification fall under D84, including complement system defects associated with hereditary angioedema and recurrent infections. D86 deals with sarcoidosis manifestations affecting lungs, lymph nodes, skin, and other organs, sometimes called pulmonary sarcoidosis or neurosarcoidosis. Lastly, D89 covers miscellaneous immune disorders such as polyclonal hypergammaglobulinemia, cryoglobulinemia, mast cell activation syndromes, graft-versus-host disease, autoimmune lymphoproliferative syndrome, cytokine release syndromes, and IgG4-related disease. These detailed codes help healthcare professionals accurately document and manage immune mechanism disorders.
Questions About This Page
How many codes are in the D80-D89 range?
The D80-D89 range contains 100 ICD-10-CM diagnosis codes in FY 2026. 83 of them are billable, and the rest are category headers that organize the section.
What conditions does D80-D89 cover?
The range covers certain disorders involving the immune mechanism. The code ranges listed above break it into groups of related conditions, and each one links to its own page with the full code list.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
