R82.3 - Hemoglobinuria

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

• Acquired hemoglobinopathy
• Acquired methemoglobinuria
• Carboxyhemoglobinuria
• Hemoglobinuria
• Hemoglobinuria
• Methemoglobinuria
• Postparturient hemoglobinuria
• Sulfhemoglobinuria

Clinical Information

• Hemoglobinuria-. the presence of free hemoglobin in the urine, indicating hemolysis of erythrocytes within the vascular system. after saturating the hemoglobin-binding proteins (haptoglobins), free hemoglobin begins to appear in the urine.
• Hemoglobinuria, Paroxysmal-. a condition characterized by the recurrence of hemoglobinuria caused by intravascular hemolysis. in cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. in cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.
• Blackwater Fever|Malarial Hemoglobinuria-. a complication of malaria resulting from hemolysis.
• Grade 1 Hemoglobinuria, CTCAE|Grade 1 Hemoglobinuria|Grade 1 Hemoglobinuria-. asymptomatic; clinical or diagnostic observations only; intervention not indicated
• Hemoglobinuria-. a laboratory test result which indicates free hemoglobin in the urine.
• Hemoglobinuria due to Hemolysis from External Causes-. hemoglobin in the urine that is due to hemolysis from an external cause.
• Hemoglobinuria, CTCAE 5.0|Hemoglobinuria|Hemoglobinuria-. a disorder characterized by laboratory test results that indicate the presence of free hemoglobin in the urine.
• Paroxysmal Nocturnal Hemoglobinuria|PNH|PNH|Paroxysmal Hemoglobinuria|paroxysmal nocturnal hemoglobinuria-. a rare acquired hematologic disorder characterized by hemolytic anemia, dark-colored urine due to the release of hemoglobin in the blood, and thrombosis. the episodes of hemolysis tend to occur at night. it is caused by a somatic mutation in the glycosylphosphatidylinositol biosynthesis gene.
• PIGA Gene Mutation|GPI3 Gene Mutation|MCAHS2 Gene Mutation|PIG-A Gene Mutation|PNH1 Gene Mutation|Paroxysmal Nocturnal Hemoglobinuria Gene Mutation|Phosphatidylinositol Glycan Anchor Biosynthesis Class A Gene Mutation-. a change in the nucleotide sequence of the piga gene.
• PIGA wt Allele|GPI3|MCAHS2|PIG-A|PNH1|Paroxysmal Nocturnal Hemoglobinuria Gene|Phosphatidylinositol Glycan Anchor Biosynthesis Class A wt Allele|Phosphatidylinositol Glycan Anchor Biosynthesis, Class A Gene|Phosphatidylinositol Glycan, Class A (Paroxysmal Nocturnal Hemoglobinuria) Gene-. human piga wild-type allele is located in the vicinity of xp22.1 and is approximately 16 kb in length. this allele, which encodes phosphatidylinositol n-acetylglucosaminyltransferase subunit a protein, plays a role in the modulation of protein lipidation. mutation of the gene is associated with paroxysmal nocturnal hemoglobinuria.

Diagnostic Related Groups - MS-DRG Mapping

The is diagnosis code is grouped in the following groups for version MS-DRG V40.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC). applicable from 10/01/2022 through 09/30/2023.

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Patient Education

Urine and Urination

Your kidneys make urine by filtering wastes and extra water from your blood. The waste is called urea. Your blood carries it to the kidneys. From the kidneys, urine travels down two thin tubes called ureters to the bladder. The bladder stores urine until you are ready to urinate. It swells into a round shape when it is full and gets smaller when empty. If your urinary system is healthy, your bladder can hold up to 16 ounces (2 cups) of urine comfortably for 2 to 5 hours.

You may have problems with urination if you have:

• Kidney failure
• Urinary tract infections
• An enlarged prostate
• Bladder control problems like incontinence, overactive bladder, or interstitial cystitis
• A blockage that prevents you from emptying your bladder

Some conditions may also cause you to have blood or protein in your urine. If you have a urinary problem, see your health care provider. Urinalysis and other urine tests can help to diagnose the problem. Treatment depends on the cause.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Code History

• FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
• FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
• FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
• FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
• FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
• FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
• FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
• FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016 (First year ICD-10-CM implemented into the HIPAA code set)