ICD-10-CM Code D89

Other disorders involving the immune mechanism, not elsewhere classified

Version 2021 Non-Billable Code

Not Valid for Submission

D89 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of other disorders involving the immune mechanism, not elsewhere classified. The code is NOT valid for the year 2021 for the submission of HIPAA-covered transactions.

ICD-10:D89
Short Description:Oth disorders involving the immune mechanism, NEC
Long Description:Other disorders involving the immune mechanism, not elsewhere classified

Consider the following ICD-10 codes with a higher level of specificity:

  • D89.0 - Polyclonal hypergammaglobulinemia
  • D89.1 - Cryoglobulinemia
  • D89.2 - Hypergammaglobulinemia, unspecified
  • D89.3 - Immune reconstitution syndrome
  • D89.4 - Mast cell activation syndrome and related disorders
  • D89.40 - Mast cell activation, unspecified
  • D89.41 - Monoclonal mast cell activation syndrome
  • D89.42 - Idiopathic mast cell activation syndrome
  • D89.43 - Secondary mast cell activation
  • D89.49 - Other mast cell activation disorder
  • D89.8 - Other specified disorders involving the immune mechanism, not elsewhere classified
  • D89.81 - Graft-versus-host disease
  • D89.810 - Acute graft-versus-host disease
  • D89.811 - Chronic graft-versus-host disease
  • D89.812 - Acute on chronic graft-versus-host disease
  • D89.813 - Graft-versus-host disease, unspecified
  • D89.82 - Autoimmune lymphoproliferative syndrome [ALPS]
  • D89.83 - Cytokine release syndrome
  • D89.831 - Cytokine release syndrome, grade 1
  • D89.832 - Cytokine release syndrome, grade 2
  • D89.833 - Cytokine release syndrome, grade 3
  • D89.834 - Cytokine release syndrome, grade 4
  • D89.835 - Cytokine release syndrome, grade 5
  • D89.839 - Cytokine release syndrome, grade unspecified
  • D89.89 - Other specified disorders involving the immune mechanism, not elsewhere classified
  • D89.9 - Disorder involving the immune mechanism, unspecified

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code D89:

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • hyperglobulinemia NOS R77.1
  • monoclonal gammopathy of undetermined significance D47.2

Type 2 Excludes

Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
  • transplant failure and rejection T86

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
    • Certain disorders involving the immune mechanism (D80-D89)
      • Oth disorders involving the immune mechanism, NEC (D89)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients


Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. It helps your body to recognize these "foreign" invaders. Then its job is to keep them out, or if it can't, to find and destroy them.

If your immune system cannot do its job, the results can be serious. Disorders of the immune system include

  • Allergy and asthma - immune responses to substances that are usually not harmful
  • Immune deficiency diseases - disorders in which the immune system is missing one or more of its parts
  • Autoimmune diseases - diseases causing your immune system to attack your own body's cells and tissues by mistake

NIH: National Institute of Allergy and Infectious Diseases

  • Agammaglobulinemia (Medical Encyclopedia)
  • Aging changes in immunity (Medical Encyclopedia)
  • Chronic granulomatous disease (Medical Encyclopedia)
  • Graft-versus-host disease (Medical Encyclopedia)
  • Histiocytosis (Medical Encyclopedia)
  • Hyperimmunoglobulin E syndrome (Medical Encyclopedia)
  • Immune response (Medical Encyclopedia)
  • Immunodeficiency disorders (Medical Encyclopedia)
  • Selective deficiency of IgA (Medical Encyclopedia)

[Learn More]