2022 ICD-10-CM Code D89

Other disorders involving the immune mechanism, not elsewhere classified

Version 2021

Not Valid for Submission

ICD-10:D89
Short Description:Oth disorders involving the immune mechanism, NEC
Long Description:Other disorders involving the immune mechanism, not elsewhere classified

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
    • Certain disorders involving the immune mechanism (D80-D89)
      • Oth disorders involving the immune mechanism, NEC (D89)

D89 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of other disorders involving the immune mechanism, not elsewhere classified. The code is not specific and is NOT valid for the year 2022 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding for Oth disorders involving the immune mechanism, NEC

Non-specific codes like D89 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10 codes with a higher level of specificity when coding for oth disorders involving the immune mechanism, nec:

  • BILLABLE CODE - Use D89.0 for Polyclonal hypergammaglobulinemia
  • BILLABLE CODE - Use D89.1 for Cryoglobulinemia
  • BILLABLE CODE - Use D89.2 for Hypergammaglobulinemia, unspecified
  • BILLABLE CODE - Use D89.3 for Immune reconstitution syndrome
  • NON-BILLABLE CODE - D89.4 for Mast cell activation syndrome and related disorders
  • BILLABLE CODE - Use D89.40 for Mast cell activation, unspecified
  • BILLABLE CODE - Use D89.41 for Monoclonal mast cell activation syndrome
  • BILLABLE CODE - Use D89.42 for Idiopathic mast cell activation syndrome
  • BILLABLE CODE - Use D89.43 for Secondary mast cell activation
  • BILLABLE CODE - Use D89.44 for Hereditary alpha tryptasemia
  • BILLABLE CODE - Use D89.49 for Other mast cell activation disorder
  • NON-BILLABLE CODE - D89.8 for Other specified disorders involving the immune mechanism, not elsewhere classified
  • NON-BILLABLE CODE - D89.81 for Graft-versus-host disease
  • BILLABLE CODE - Use D89.82 for Autoimmune lymphoproliferative syndrome [ALPS]
  • NON-BILLABLE CODE - D89.83 for Cytokine release syndrome
  • BILLABLE CODE - Use D89.89 for Other specified disorders involving the immune mechanism, not elsewhere classified
  • BILLABLE CODE - Use D89.9 for Disorder involving the immune mechanism, unspecified

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code D89:


Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

Type 2 Excludes

Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.

Information for Patients


Immune System and Disorders

What is the immune system?

Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.

When germs such as bacteria or viruses invade your body, they attack and multiply. This is called an infection. The infection causes the disease that makes you sick. Your immune system protects you from the disease by fighting off the germs.

What are the parts of the immune system?

The immune system has many different parts, including

How does the immune system work?

Your immune system defends your body against substances it sees as harmful or foreign. These substances are called antigens. They may be germs such as bacteria and viruses. They might be chemicals or toxins. They could also be cells that are damaged from things like cancer or sunburn.

When your immune system recognizes an antigen, it attacks it. This is called an immune response. Part of this response is to make antibodies. Antibodies are proteins that work to attack, weaken, and destroy antigens. Your body also makes other cells to fight the antigen.

Afterwards, your immune system remembers the antigen. If it sees the antigen again, it can recognize it. It will quickly send out the right antibodies, so in most cases, you don't get sick. This protection against a certain disease is called immunity.

What are the types of immunity?

There are three different types of immunity:

What can go wrong with the immune system?

Sometimes a person may have an immune response even though there is no real threat. This can lead to problems such as allergies, asthma, and autoimmune diseases. If you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake.

Other immune system problems happen when your immune system does not work correctly. These problems include immunodeficiency diseases. If you have an immunodeficiency disease, you get sick more often. Your infections may last longer and can be more serious and harder to treat. They are often genetic disorders.

There are other diseases that can affect your immune system. For example, HIV is a virus that harms your immune system by destroying your white blood cells. If HIV is not treated, it can lead to AIDS (acquired immunodeficiency syndrome). People with AIDS have badly damaged immune systems. They get an increasing number of severe illnesses.


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Code History

  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016 (First year ICD-10-CM implemented into the HIPAA code set)