2022 ICD-10-CM Code D80

Immunodeficiency with predominantly antibody defects

Version 2021

Not Valid for Submission

ICD-10:D80
Short Description:Immunodeficiency with predominantly antibody defects
Long Description:Immunodeficiency with predominantly antibody defects

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
    • Certain disorders involving the immune mechanism (D80-D89)
      • Immunodeficiency with predominantly antibody defects (D80)

D80 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of immunodeficiency with predominantly antibody defects. The code is not specific and is NOT valid for the year 2022 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding for Immunodeficiency with predominantly antibody defects

Non-specific codes like D80 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10 codes with a higher level of specificity when coding for immunodeficiency with predominantly antibody defects:

  • BILLABLE CODE - Use D80.0 for Hereditary hypogammaglobulinemia
  • BILLABLE CODE - Use D80.1 for Nonfamilial hypogammaglobulinemia
  • BILLABLE CODE - Use D80.2 for Selective deficiency of immunoglobulin A [IgA]
  • BILLABLE CODE - Use D80.3 for Selective deficiency of immunoglobulin G [IgG] subclasses
  • BILLABLE CODE - Use D80.4 for Selective deficiency of immunoglobulin M [IgM]
  • BILLABLE CODE - Use D80.5 for Immunodeficiency with increased immunoglobulin M [IgM]
  • BILLABLE CODE - Use D80.6 for Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
  • BILLABLE CODE - Use D80.7 for Transient hypogammaglobulinemia of infancy
  • BILLABLE CODE - Use D80.8 for Other immunodeficiencies with predominantly antibody defects
  • BILLABLE CODE - Use D80.9 for Immunodeficiency with predominantly antibody defects, unspecified

Information for Patients


Immune System and Disorders

What is the immune system?

Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.

When germs such as bacteria or viruses invade your body, they attack and multiply. This is called an infection. The infection causes the disease that makes you sick. Your immune system protects you from the disease by fighting off the germs.

What are the parts of the immune system?

The immune system has many different parts, including

How does the immune system work?

Your immune system defends your body against substances it sees as harmful or foreign. These substances are called antigens. They may be germs such as bacteria and viruses. They might be chemicals or toxins. They could also be cells that are damaged from things like cancer or sunburn.

When your immune system recognizes an antigen, it attacks it. This is called an immune response. Part of this response is to make antibodies. Antibodies are proteins that work to attack, weaken, and destroy antigens. Your body also makes other cells to fight the antigen.

Afterwards, your immune system remembers the antigen. If it sees the antigen again, it can recognize it. It will quickly send out the right antibodies, so in most cases, you don't get sick. This protection against a certain disease is called immunity.

What are the types of immunity?

There are three different types of immunity:

What can go wrong with the immune system?

Sometimes a person may have an immune response even though there is no real threat. This can lead to problems such as allergies, asthma, and autoimmune diseases. If you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake.

Other immune system problems happen when your immune system does not work correctly. These problems include immunodeficiency diseases. If you have an immunodeficiency disease, you get sick more often. Your infections may last longer and can be more serious and harder to treat. They are often genetic disorders.

There are other diseases that can affect your immune system. For example, HIV is a virus that harms your immune system by destroying your white blood cells. If HIV is not treated, it can lead to AIDS (acquired immunodeficiency syndrome). People with AIDS have badly damaged immune systems. They get an increasing number of severe illnesses.


[Learn More in MedlinePlus]

Code History

  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016 (First year ICD-10-CM implemented into the HIPAA code set)