ICD-10-CM Code D80

Immunodeficiency with predominantly antibody defects

Version 2021 Non-Billable Code

Not Valid for Submission

D80 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of immunodeficiency with predominantly antibody defects. The code is NOT valid for the year 2021 for the submission of HIPAA-covered transactions.

ICD-10:D80
Short Description:Immunodeficiency with predominantly antibody defects
Long Description:Immunodeficiency with predominantly antibody defects

Consider the following ICD-10 codes with a higher level of specificity:

  • D80.0 - Hereditary hypogammaglobulinemia
  • D80.1 - Nonfamilial hypogammaglobulinemia
  • D80.2 - Selective deficiency of immunoglobulin A [IgA]
  • D80.3 - Selective deficiency of immunoglobulin G [IgG] subclasses
  • D80.4 - Selective deficiency of immunoglobulin M [IgM]
  • D80.5 - Immunodeficiency with increased immunoglobulin M [IgM]
  • D80.6 - Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
  • D80.7 - Transient hypogammaglobulinemia of infancy
  • D80.8 - Other immunodeficiencies with predominantly antibody defects
  • D80.9 - ... unspecified

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
    • Certain disorders involving the immune mechanism (D80-D89)
      • Immunodeficiency with predominantly antibody defects (D80)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients


Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. It helps your body to recognize these "foreign" invaders. Then its job is to keep them out, or if it can't, to find and destroy them.

If your immune system cannot do its job, the results can be serious. Disorders of the immune system include

  • Allergy and asthma - immune responses to substances that are usually not harmful
  • Immune deficiency diseases - disorders in which the immune system is missing one or more of its parts
  • Autoimmune diseases - diseases causing your immune system to attack your own body's cells and tissues by mistake

NIH: National Institute of Allergy and Infectious Diseases

  • Agammaglobulinemia (Medical Encyclopedia)
  • Aging changes in immunity (Medical Encyclopedia)
  • Chronic granulomatous disease (Medical Encyclopedia)
  • Graft-versus-host disease (Medical Encyclopedia)
  • Histiocytosis (Medical Encyclopedia)
  • Hyperimmunoglobulin E syndrome (Medical Encyclopedia)
  • Immune response (Medical Encyclopedia)
  • Immunodeficiency disorders (Medical Encyclopedia)
  • Selective deficiency of IgA (Medical Encyclopedia)

[Learn More]