2026 ICD-10-CM Diagnosis Code D80Immunodeficiency with predominantly antibody defects

ICD-10-CM Codes›D50–D89›D80-D89›D80

ICD-10-CM D80
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D80 is a non-billable ICD-10-CM category code for immunodeficiency with predominantly antibody defects, so it cannot be submitted on claims. Use a more specific code from this category instead, such as D80.0, D80.1, D80.2, and D80.3.

Code Identity

ICD-10-CM Code
D80
Billable Status
No — Non-Billable Category
Code Describes
Immunodeficiency with predominantly antibody defects
Chapter
D80-D89
Certain disorders involving the immune mechanism

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD80-D89Certain disorders involving the immune mechanism
CategoryD80Immunodeficiency with predominantly antibody defects
This CodeD80Immunodeficiency with predominantly antibody defects

Specific Coding for Immunodeficiency with predominantly antibody defectsOverview

Non-specific codes like D80 require more characters. Use one of these billable codes instead:

  • Use D80.0 for Hereditary hypogammaglobulinemia

  • Use D80.1 for Nonfamilial hypogammaglobulinemia

  • Use D80.2 for Selective deficiency of immunoglobulin A [IgA]

  • Use D80.3 for Selective deficiency of immunoglobulin G [IgG] subclasses

  • Use D80.4 for Selective deficiency of immunoglobulin M [IgM]

  • Use D80.5 for Immunodeficiency with increased immunoglobulin M [IgM]

  • Use D80.6 for Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia

  • Use D80.7 for Transient hypogammaglobulinemia of infancy

  • Use D80.8 for Other immunodeficiencies with predominantly antibody defects

  • Use D80.9 for Immunodeficiency with predominantly antibody defects, unspecified

Patient EducationClinical

Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.

The full article covers:

  • What is the immune system?
  • What are the parts of the immune system?
  • How does the immune system work?
  • What are the types of immunity?
  • What can go wrong with the immune system?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D80Overview

Is D80 (Immunodeficiency with predominantly antibody defects) a billable code?

No. This is a category header that groups the codes for immunodeficiency with predominantly antibody defects, and headers cannot be submitted on claims. Claims for immunodeficiency with predominantly antibody defects need a more specific code from this category, such as D80.0, D80.1, and D80.2.