2024 ICD-10-CM Diagnosis Code D89.1


ICD-10-CM Code:
ICD-10 Code for:
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Code Navigator:

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
    • Certain disorders involving the immune mechanism
      • Other disorders involving the immune mechanism, not elsewhere classified

D89.1 is a billable diagnosis code used to specify a medical diagnosis of cryoglobulinemia. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Cryofibrinogenemia
  • Cryofibrinogenemic purpura
  • Cryoglobulinemia
  • Cryoglobulinemia
  • Cryoglobulinemia due to chronic hepatitis C
  • Cryoglobulinemic glomerulonephritis
  • Cryoglobulinemic purpura
  • Cryoglobulinemic vasculitis
  • Cryoglobulinemic vasculitis
  • Drug-induced necrotizing vasculitis
  • Essential mixed cryoglobulinemia
  • Mixed cryoimmunoglobulinemia with monoclonal component
  • Mixed polyclonal cryoimmunoglobulinemia
  • Monoclonal cryoimmunoglobulinemia
  • Mononeuritis
  • Mononeuritis multiplex
  • Mononeuritis multiplex due to cryoglobulinemic vasculitis
  • Necrotizing cutaneous vasculitis
  • Necrotizing vasculitis due to mixed cryoglobulinemia
  • Nephritis caused by drug
  • Neuropathy associated with dysproteinemias
  • Neuropathy in cryoglobulinemia
  • Occlusion of microvasculature of skin caused by cryoglobulin type III
  • Polyclonal gammopathy
  • Primary cryoglobulinemia
  • Secondary cryofibrinogenemia
  • Secondary cryoglobulinemia
  • Secondary cryoglobulinemia
  • Simple cryoglobulinemia
  • Small vessel vasculitis caused by immune complex
  • Small vessel vasculitis caused by immune complex
  • Vasculitic mononeuritis multiplex
  • Vasculitis secondary to drug
  • Vasculitis secondary to drug

Clinical Classification

Clinical Information

  • Cryoglobulinemia

    a condition characterized by the presence of abnormal quantities of cryoglobulins in the blood. upon cold exposure, these abnormal proteins precipitate into the microvasculature leading to restricted blood flow in the exposed areas.
  • Cryoglobulins

    abnormal immunoglobulins, especially igg or igm, that precipitate spontaneously when serum is cooled below 37 degrees celsius. it is characteristic of cryoglobulinemia.
  • Cryoglobulinemia

    a condition characterized by the presence of cryoglobulins in the blood. cryoglobulins are abnormal proteins that precipitate within the microvasculature on exposure to cold; microvasculature effects of cryoglobulinemia may result in restricted tissue blood flow, tissue hypoxia, and tissue necrosis. --2004
  • Cryoglobulinemic Glomerulonephritis

    glomerulonephritis in the context of cryoglobulinemia.
  • Cryoglobulinemic Glomerulonephritis Secondary to Systemic Disease

    cryoglobulinemia glomerulonephritis associated with chronic disease, often inflammatory conditions.
  • Type I Cryoglobulinemic Glomerulonephritis

    glomerulonephritis caused by cryoglobulins which are composed of monoclonal immunoglobulins igg, iga, or igm. it occurs in patients with lymphoproliferative disorders.
  • Mononeuritis Multiplex

    a painful asymmetric asynchronous sensory and motor peripheral neuropathy involving isolated damage to at least 2 separate nerve areas; associated with (but not limited to) systemic disorders such as diabetes, vasculitis, amyloidosis, direct tumor involvement, polyarteritis nodosa, rheumatoid arthritis, systemic lupus erythematosus, and paraneoplastic syndromes. it also may be associated with lyme disease, wegener's granulomatosis, sjogren syndrome, cryoglobulinemia, hypereosinophilia, temporal arteritis, scleroderma, sarcoidosis, leprosy, acute viral hepatitis a, and acquired immunodeficiency syndrome.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Cryoglobulinemic purpura
  • Cryoglobulinemic vasculitis
  • Essential cryoglobulinemia
  • Idiopathic cryoglobulinemia
  • Mixed cryoglobulinemia
  • Primary cryoglobulinemia
  • Secondary cryoglobulinemia

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert D89.1 to ICD-9-CM

  • ICD-9-CM Code: 273.2 - Paraproteinemia NEC

Patient Education

Immune System and Disorders

What is the immune system?

Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.

When germs such as bacteria or viruses invade your body, they attack and multiply. This is called an infection. The infection causes the disease that makes you sick. Your immune system protects you from the disease by fighting off the germs.

What are the parts of the immune system?

The immune system has many different parts, including:

  • Your skin, which can help prevent germs from getting into the body
  • Mucous membranes, which are the moist, inner linings of some organs and body cavities. They make mucus and other substances which can trap and fight germs.
  • White blood cells, which fight germs
  • Organs and tissues of the lymph system, such as the thymus, spleen, tonsils, lymph nodes, lymph vessels, and bone marrow. They produce, store, and carry white blood cells.

How does the immune system work?

Your immune system defends your body against substances it sees as harmful or foreign. These substances are called antigens. They may be germs such as bacteria and viruses. They might be chemicals or toxins. They could also be cells that are damaged from things like cancer or sunburn.

When your immune system recognizes an antigen, it attacks it. This is called an immune response. Part of this response is to make antibodies. Antibodies are proteins that work to attack, weaken, and destroy antigens. Your body also makes other cells to fight the antigen.

Afterwards, your immune system remembers the antigen. If it sees the antigen again, it can recognize it. It will quickly send out the right antibodies, so in most cases, you don't get sick. This protection against a certain disease is called immunity.

What are the types of immunity?

There are three different types of immunity:

  • Innate immunity is the protection that you are born with. It is your body's first line of defense. It includes barriers such as the skin and mucous membranes. They keep harmful substances from entering the body. It also includes some cells and chemicals which can attack foreign substances.
  • Active immunity, also called adaptive immunity, develops when you are infected with or vaccinated against a foreign substance. Active immunity is usually long-lasting. For many diseases, it can last your entire life.
  • Passive immunity happens when you receive antibodies to a disease instead of making them through your own immune system. For example, newborn babies have antibodies from their mothers. People can also get passive immunity through blood products that contain antibodies. This kind of immunity gives you protection right away. But it only lasts a few weeks or months.

What can go wrong with the immune system?

Sometimes a person may have an immune response even though there is no real threat. This can lead to problems such as allergies, asthma, and autoimmune diseases. If you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake.

Other immune system problems happen when your immune system does not work correctly. These problems include immunodeficiency diseases. If you have an immunodeficiency disease, you get sick more often. Your infections may last longer and can be more serious and harder to treat. They are often genetic disorders.

There are other diseases that can affect your immune system. For example, HIV is a virus that harms your immune system by destroying your white blood cells. If HIV is not treated, it can lead to AIDS (acquired immunodeficiency syndrome). People with AIDS have badly damaged immune systems. They get an increasing number of severe illnesses.

[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.


[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.