ICD-10-CM Code D84.9

Immunodeficiency, unspecified

Version 2021 Billable Code

Valid for Submission

D84.9 is a billable code used to specify a medical diagnosis of immunodeficiency, unspecified. The code is valid for the fiscal year 2021 for the submission of HIPAA-covered transactions. The ICD-10-CM code D84.9 might also be used to specify conditions or terms like adult-onset immunodeficiency, age-related immunodeficiency, anhidrotic ectodermal dysplasia with immune deficiency, centromeric instability of chromosomes 1,9 and 16 and immunodeficiency, congenital anomaly of endocrine ovary, congenital immunodeficiency disease, etc

Short Description:Immunodeficiency, unspecified
Long Description:Immunodeficiency, unspecified

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code D84.9:

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Immunocompromised NOS
  • Immunodeficient NOS
  • Immunosuppressed NOS

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code D84.9 are found in the index:


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Adult-onset immunodeficiency
  • Age-related immunodeficiency
  • Anhidrotic ectodermal dysplasia with immune deficiency
  • Centromeric instability of chromosomes 1,9 and 16 and immunodeficiency
  • Congenital anomaly of endocrine ovary
  • Congenital immunodeficiency disease
  • Congenital livedo reticularis
  • Drug-induced immunodeficiency
  • Facial dysmorphism, immunodeficiency, livedo, short stature syndrome
  • Factor I deficiency
  • Iatrogenic immunodeficiency-associated lymphoproliferative disorder
  • Immunodeficiency caused by long term therapeutic use of drug
  • Immunodeficiency disorder
  • Immunodeficiency secondary to chemotherapy
  • Immunodeficiency secondary to corticosteroid
  • Immunodeficiency secondary to neoplasm
  • Immunodeficiency secondary to radiation therapy
  • Immunodeficiency secondary to trauma
  • Immunodeficiency with factor I anomaly
  • Immunodeficiency with thymoma
  • Immuno-osseous dysplasia
  • Immunosuppression
  • Laron syndrome with immunodeficiency
  • Livedo reticularis
  • Lung fibrosis, immunodeficiency, 46,XX gonadal dysgenesis syndrome
  • Microcephaly, normal intelligence and immunodeficiency
  • Oral hairy leukoplakia associated with immunodeficiency
  • Ovarian dysgenesis
  • Patient immunocompromised
  • Patient immunosuppressed
  • Primary immune deficiency disorder
  • Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection
  • Pure gonadal dysgenesis
  • Pure gonadal dysgenesis 46,XX
  • Roifman syndrome
  • Secondary immune deficiency disorder
  • Susceptibility to viral and mycobacterial infection

Clinical Information

  • GATA2 DEFICIENCY-. a rare disorder of the immune system with wide ranging effects which include gata2 transcription factor dysfunction immunodeficiency myelodysplastic syndrome ineffective blood cell production lung disease and problems of the vascular and lymphatic system.
  • PRIMARY IMMUNODEFICIENCY DISEASES-. genetic immunologic deficiency diseases and syndromes due to mutations in genes involved in immunity generally characterized by an increased susceptibility to infectious diseases. they are often associated with autoimmune disease manifestations.
  • ACQUIRED IMMUNODEFICIENCY SYNDROME-. an acquired defect of cellular immunity associated with infection by the human immunodeficiency virus hiv a cd4 positive t lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes and increased susceptibility to opportunistic infections and malignant neoplasms. clinical manifestations also include emaciation wasting and dementia. these elements reflect criteria for aids as defined by the cdc in 1993.
  • HIV-. human immunodeficiency virus. a non taxonomic and historical term referring to any of two species specifically hiv 1 and/or hiv 2. prior to 1986 this was called human t lymphotropic virus type iii/lymphadenopathy associated virus htlv iii/lav. from 1986 1990 it was an official species called hiv. since 1991 hiv was no longer considered an official species name; the two species were designated hiv 1 and hiv 2.
  • LYMPHOPROLIFERATIVE DISORDERS-. disorders characterized by proliferation of lymphoid tissue general or unspecified.
  • WISKOTT ALDRICH SYNDROME-. a rare x linked immunodeficiency syndrome characterized by eczema; lymphopenia; and recurrent pyogenic infection. it is seen exclusively in young boys. typically immunoglobulin m levels are low and immunoglobulin a and immunoglobulin e levels are elevated. lymphoreticular malignancies are common.
  • SIMIAN IMMUNODEFICIENCY VIRUS-. species of the genus lentivirus subgenus primate immunodeficiency viruses immunodeficiency viruses primate that induces acquired immunodeficiency syndrome in monkeys and apes saids. the genetic organization of siv is virtually identical to hiv.
  • HIV 1-. the type species of lentivirus and the etiologic agent of aids. it is characterized by its cytopathic effect and affinity for the t4 lymphocyte.
  • HIV 2-. an hiv species related to hiv 1 but carrying different antigenic components and with differing nucleic acid composition. it shares serologic reactivity and sequence homology with the simian lentivirus simian immunodeficiency virus and infects only t4 lymphocytes expressing the cd4 phenotypic marker.
  • IMMUNODEFICIENCY VIRUS BOVINE-. the type species of lentivirus subgenus bovine lentiviruses lentiviruses bovine found in cattle and causing lymphadenopathy lymphocytosis central nervous system lesions progressive weakness and emaciation. it has immunological cross reactivity with other lentiviruses including hiv.
  • IMMUNODEFICIENCY VIRUS FELINE-. a species of lentivirus subgenus feline lentiviruses lentiviruses feline isolated from cats with a chronic wasting syndrome presumed to be immune deficiency. there are 3 strains: petaluma fip p oma fip o and puma lentivirus plv. there is no antigenic relationship between fiv and hiv nor does fiv grow in human t cells.
  • SEVERE COMBINED IMMUNODEFICIENCY-. group of rare congenital disorders characterized by impairment of both humoral and cell mediated immunity leukopenia and low or absent antibody levels. it is inherited as an x linked or autosomal recessive defect. mutations occurring in many different genes cause human severe combined immunodeficiency scid.
  • COMMON VARIABLE IMMUNODEFICIENCY-. heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes variable b cell defects and the presence of recurrent bacterial infections.
  • LENTIVIRUSES PRIMATE-. a subgenus of lentivirus comprising viruses that produce immunodeficiencies in primates including humans.
  • NIJMEGEN BREAKAGE SYNDROME-. a chromosome instability syndrome resulting from a defective response to dna double strand breaks. in addition to characteristic facies and microcephaly patients have a range of findings including radiosensitivity immunodeficiency increased cancer risk and growth retardation. causative mutations occur in the nbs1 gene located on human chromosome 8q21. nbs1 codes for nibrin the key regulator protein of the r/m/n rad50/mre11/nbs1 protein complex which senses and mediates cellular response to dna damage caused by ionizing radiation.
  • HYPER IGM IMMUNODEFICIENCY SYNDROME-. a rare inherited immunodeficiency syndrome characterized by normal or elevated serum immunoglobulin m levels with absence of immunoglobulin g; immunoglobulin a; and immunoglobulin e. it results in a profound susceptibility to bacterial infections and an increased susceptibility to opportunistic infections. several subtypes of hyper igm immunodeficiency syndrome exist depending upon the location of genetic mutation.
  • HYPER IGM IMMUNODEFICIENCY SYNDROME TYPE 1-. an x linked hyper igm immunodeficiency subtype resulting from mutation in the gene encoding cd40 ligand.
  • X LINKED COMBINED IMMUNODEFICIENCY DISEASES-. forms of combined immunodeficiency caused by mutations in the gene for interleukin receptor common gamma subunit. both severe and non severe subtypes of the disease have been identified.

Diagnostic Related Groups

The ICD-10 code D84.9 is grouped in the following groups for version MS-DRG V38.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2020 through 09/30/2021.


Convert D84.9 to ICD-9

  • 279.3 - Immunity deficiency NOS (Approximate Flag)

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
    • Certain disorders involving the immune mechanism (D80-D89)
      • Other immunodeficiencies (D84)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients

Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. It helps your body to recognize these "foreign" invaders. Then its job is to keep them out, or if it can't, to find and destroy them.

If your immune system cannot do its job, the results can be serious. Disorders of the immune system include

  • Allergy and asthma - immune responses to substances that are usually not harmful
  • Immune deficiency diseases - disorders in which the immune system is missing one or more of its parts
  • Autoimmune diseases - diseases causing your immune system to attack your own body's cells and tissues by mistake

NIH: National Institute of Allergy and Infectious Diseases

  • Agammaglobulinemia (Medical Encyclopedia)
  • Aging changes in immunity (Medical Encyclopedia)
  • Chronic granulomatous disease (Medical Encyclopedia)
  • Graft-versus-host disease (Medical Encyclopedia)
  • Histiocytosis (Medical Encyclopedia)
  • Hyperimmunoglobulin E syndrome (Medical Encyclopedia)
  • Immune response (Medical Encyclopedia)
  • Immunodeficiency disorders (Medical Encyclopedia)
  • Selective deficiency of IgA (Medical Encyclopedia)

[Learn More]