ICD-10-CM Code D89.89

Other specified disorders involving the immune mechanism, not elsewhere classified

Version 2020 Replaced Code Billable Code

Valid for Submission

D89.89 is a billable code used to specify a medical diagnosis of other specified disorders involving the immune mechanism, not elsewhere classified. The code is valid for the year 2020 for the submission of HIPAA-covered transactions. The ICD-10-CM code D89.89 might also be used to specify conditions or terms like antibody-mediated cytolysis, anti-human leukocyte antigen hyperimmunization, autoimmune disorder of bilateral inner ears, autoimmune disorder of inner ear, autoimmune enteropathy, autoimmune enteropathy, etc

Short Description:Oth disrd involving the immune mechanism, NEC
Long Description:Other specified disorders involving the immune mechanism, not elsewhere classified

Replaced Code

This code was replaced in the 2020 ICD-10 code set with the code(s) listed below. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2019. This code was replaced for the FY 2020 (October 1, 2019 - September 30, 2020).

  • D89.40 - Mast cell activation, unspecified
  • D89.41 - Monoclonal mast cell activation syndrome
  • D89.42 - Idiopathic mast cell activation syndrome
  • D89.43 - Secondary mast cell activation
  • D89.49 - Other mast cell activation disorder

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code D89.89:

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • human immunodeficiency virus disease B20

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code D89.89 are found in the index:


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Antibody-mediated cytolysis
  • Anti-human leukocyte antigen hyperimmunization
  • Autoimmune disorder of bilateral inner ears
  • Autoimmune disorder of inner ear
  • Autoimmune enteropathy
  • Autoimmune enteropathy
  • Autoimmune enteropathy and endocrinopathy with susceptibility to chronic infection syndrome
  • Autoimmune reaction mediated by antibody to tissue element with complement
  • Autoimmune reaction mediated by antibody to tissue element without complement
  • Autoimmune reaction mediated by B cells
  • Autoimmune reaction mediated by cell-mediated immunity
  • Autoimmune reaction mediated by immune complex
  • Autoimmune reaction mediated by T cells
  • Autoimmune reaction, specific organ or cell type
  • Autoimmune state
  • Autoleukocyte sensitivity
  • Autologous state
  • Autosensitivity
  • BCG granuloma
  • Cytokine release syndrome
  • Diffuse antibody band pattern
  • Disorder of immunoglobulin
  • Familial immunoglobulin hypercatabolism
  • Hyperimmune state
  • Immune dysregulation, inflammatory bowel disease, arthritis, recurrent infection syndrome
  • Immunoglobulin hypercatabolism
  • Immunologic patching
  • Impaired phagocytosis
  • Infection due to Mycobacterium bovis
  • Inflammatory disorder of immune system
  • Isoimmunization
  • Low immunologic affinity
  • Nakajo-Nishimura syndrome
  • Postinfectious autoimmune reaction
  • Primary immunoglobulin catabolism abnormality
  • Primary immunoglobulin catabolism abnormality
  • Restricted antibody band pattern
  • Reticuloendothelial blockade
  • Tuftsin deficiency
  • X-linked immune dysregulation, polyendocrinopathy, enteropathy syndrome

Diagnostic Related Groups

The ICD-10 code D89.89 is grouped in the following groups for version MS-DRG V37.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2019 through 09/30/2020.


Convert D89.89 to ICD-9

  • 279.8 - Immune mechanism dis NEC (Approximate Flag)

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
    • Certain disorders involving the immune mechanism (D80-D89)
      • Oth disorders involving the immune mechanism, NEC (D89)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients

Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. It helps your body to recognize these "foreign" invaders. Then its job is to keep them out, or if it can't, to find and destroy them.

If your immune system cannot do its job, the results can be serious. Disorders of the immune system include

  • Allergy and asthma - immune responses to substances that are usually not harmful
  • Immune deficiency diseases - disorders in which the immune system is missing one or more of its parts
  • Autoimmune diseases - diseases causing your immune system to attack your own body's cells and tissues by mistake

[Learn More]