ICD-10 Code E72.8

Other specified disorders of amino-acid metabolism

Version 2019 Replaced Code Non-Billable Code
ICD-10: E72.8
Short Description:Other specified disorders of amino-acid metabolism
Long Description:Other specified disorders of amino-acid metabolism

Not Valid for Submission

ICD-10 E72.8 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of other specified disorders of amino-acid metabolism. The code is NOT valid for the year 2019 for the submission of HIPAA-covered transactions.

Consider the following ICD-10 codes with a higher level of specificity:

  • E72.81 - Disorders of gamma aminobutyric acid metabolism
  • E72.89 - Other specified disorders of amino-acid metabolism

Deleted Code

This code was deleted in the 2019 ICD-10 code set with the code(s) listed below. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2018. This code was replaced for the FY 2019 (October 1, 2018 - September 30, 2019).

  • E72.81 - Disorders of gamma aminobutyric acid metabolism
  • E72.89 - Other specified disorders of amino-acid metabolism

Code Classification

  • Endocrine, nutritional and metabolic diseases (E00–E90)
    • Metabolic disorders (E70-E88)
      • Other disorders of amino-acid metabolism (E72)

Information for Medical Professionals

Convert E72.8 to ICD-9

The following crosswalk between ICD-10 to ICD-9 is based based on the General Equivalence Mappings (GEMS) information:

  • 270.7 - Straig amin-acid met NEC (Approximate Flag)
  • 270.8 - Dis amino-acid metab NEC (Approximate Flag)


The following clinical terms are approximate synonyms:

  • 2-hydroxyglutaric aciduria
  • 3-Phosphoglycerate dehydrogenase deficiency
  • 3-phosphoglycerate dehydrogenase deficiency infantile form
  • 3-phosphoglycerate dehydrogenase deficiency juvenile form
  • 5-Oxoprolinase deficiency
  • Alaninemia
  • Alpha ketoadipic aciduria
  • Aminoacidemia
  • Aminoaciduria
  • Aminoaciduria
  • Aminoaciduria
  • Arginine:glycine amidinotransferase deficiency
  • Benign neonatal hyperaminoaciduria
  • Camptodactyly taurinuria syndrome
  • Combined D-2-hydroxyglutaric aciduria and L-2-hydroxyglutaric aciduria
  • Deficiency of 3-hydroxyisobutyrate dehydrogenase
  • Deficiency of 4-hydroxy-2-oxoglutarate aldolase
  • Deficiency of A-ase
  • Deficiency of acid-aminoacid ligase
  • Deficiency of adenosylhomocysteinase
  • Deficiency of alanine aminotransferase
  • Deficiency of alanine dehydrogenase
  • Deficiency of alanine-oxo-acid aminotransferase
  • Deficiency of alanine-tRNA ligase
  • Deficiency of aminoacylase 1
  • Deficiency of aminoacyl-histidine dipeptidase
  • Deficiency of aminoacyltransferase
  • Deficiency of aminopeptidase
  • Deficiency of aminotransferase
  • Deficiency of ammonia-lyase
  • Deficiency of asparagine-oxo-acid aminotransferase
  • Deficiency of aspartate 4-decarboxylase
  • Deficiency of aspartate aminotransferase
  • Deficiency of aspartate kinase
  • Deficiency of betaine-aldehyde dehydrogenase
  • Deficiency of betaine-homocysteine methyltransferase
  • Deficiency of carboxy-lyase
  • Deficiency of carboxypeptidase A
  • Deficiency of carboxypeptidase B
  • Deficiency of carnosinase
  • Deficiency of choline dehydrogenase
  • Deficiency of cysteamine dioxygenase
  • Deficiency of cysteine aminotransferase
  • Deficiency of cysteine carboxypeptidase
  • Deficiency of cysteine proteinase
  • Deficiency of cysteinyl-glycine dipeptidase
  • Deficiency of cystine reductase
  • Deficiency of cytosol aminopeptidase
  • Deficiency of D-amino-acid oxidase
  • Deficiency of D-aspartate oxidase
  • Deficiency of glutamate decarboxylase
  • Deficiency of glutamate dehydrogenase
  • Deficiency of glutamate-ammonia ligase
  • Deficiency of glutaminase
  • Deficiency of glutamine phenylacetyltransferase
  • Deficiency of glutamine-fructose-6-phosphate aminotransferase
  • Deficiency of glutamine-pyruvate aminotransferase
  • Deficiency of glutathione synthase
  • Deficiency of glycine amidinotransferase
  • Deficiency of glycine hydroxymethyltransferase
  • Deficiency of guanidinoacetate kinase
  • Deficiency of guanidinoacetate methyltransferase
  • Deficiency of homoserine kinase
  • Deficiency of L-amino-acid oxidase
  • Deficiency of L-asparagine amidohydrolase
  • Deficiency of L-serine dehydratase
  • Deficiency of malonate CoA-transferase
  • Deficiency of N-methyl-L-amino-acid oxidase
  • Deficiency of phosphoserine phosphatase
  • Deficiency of proline dipeptidase
  • Deficiency of pyrroline-5-carboxylate reductase
  • Deficiency of serine carboxypeptidase
  • Deficiency of serine-tRNA ligase
  • Deficiency of threonine aldolase
  • Deficiency of threonine dehydratase
  • Deficiency of threonine-tRNA ligase
  • Dibasic aminoaciduria
  • Dicarboxylic aminoaciduria syndrome
  • Disorder of beta alanine, carnosine AND/OR homocarnosine metabolism
  • Disorder of beta and omega amino acid metabolism
  • Disorder of creatine synthesis
  • Disorder of glutamine metabolism
  • Disorder of phenylalanine metabolism
  • Disorder of proline AND/OR hydroxyproline metabolism
  • Disorder of serine metabolism
  • Disorder of tetrahydrobiopterin metabolism
  • Disorder of the gamma-glutamyl cycle
  • Disorder of threonine metabolism
  • Gamma-aminobutyric acid transaminase deficiency
  • gamma-Glutamyltransferase deficiency
  • Glucoaminophosphaturia syndrome
  • Glucoaminophosphaturia syndrome with rickets
  • Glutamate-cysteine ligase deficiency
  • Glutathione synthase deficiency with 5-oxoprolinuria
  • Glutathione synthase deficiency without 5-oxoprolinuria
  • Glutathionemia
  • Glycoprolinuria
  • Homocarnosinase deficiency
  • Hyper-beta-alaninemia
  • Hyper-beta-carnosinemia
  • Hyperdicarboxylicaminoaciduria AND hyperprolinemia
  • Hyperhydroxyprolinemia
  • Hyperprolinemia
  • Iminoacidopathy
  • Inborn error of amino acid metabolism
  • Inborn error of glutathione metabolism
  • Inherited aminoaciduria
  • Inherited aminoaciduria
  • Inherited aminoaciduria
  • Lysinuric protein intolerance
  • Phosphoserine aminotransferase deficiency
  • Pipecolic acidemia
  • Prolinuria
  • Succinate-semialdehyde dehydrogenase deficiency

Information for Patients

Amino Acid Metabolism Disorders

Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Your digestive system breaks the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body. If you have a metabolic disorder, something goes wrong with this process.

One group of these disorders is amino acid metabolism disorders. They include phenylketonuria (PKU) and maple syrup urine disease. Amino acids are "building blocks" that join together to form proteins. If you have one of these disorders, your body may have trouble breaking down certain amino acids. Or there may be a problem getting the amino acids into your cells. These problems cause a buildup of harmful substances in your body. That can lead to serious, sometimes life-threatening, health problems.

These disorders are usually inherited. A baby who is born with one may not have any symptoms right away. Because the disorders can be so serious, early diagnosis and treatment are critical. Newborn babies get screened for many of them, using blood tests.

Treatments may include special diets, medicines, and supplements. Some babies may also need additional treatments if there are complications.

[Learn More]

ICD-10 Footnotes

General Equivalence Map Definitions
The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Approximate Flag - The approximate flag is on, indicating that the relationship between the code in the source system and the code in the target system is an approximate equivalent.
  • No Map Flag - The no map flag indicates that a code in the source system is not linked to any code in the target system.
  • Combination Flag - The combination flag indicates that more than one code in the target system is required to satisfy the full equivalent meaning of a code in the source system.