ICD-10-CM Code E72.89

Other specified disorders of amino-acid metabolism

Version 2021 Billable Code

Valid for Submission

E72.89 is a billable code used to specify a medical diagnosis of other specified disorders of amino-acid metabolism. The code is valid for the fiscal year 2021 for the submission of HIPAA-covered transactions. The ICD-10-CM code E72.89 might also be used to specify conditions or terms like 2-hydroxyglutaric aciduria, 3-phosphoglycerate dehydrogenase deficiency, 3-phosphoglycerate dehydrogenase deficiency infantile form, 3-phosphoglycerate dehydrogenase deficiency juvenile form, 5-oxoprolinase deficiency, alaninemia, etc

Short Description:Other specified disorders of amino-acid metabolism
Long Description:Other specified disorders of amino-acid metabolism

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code E72.89:

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Disorders of beta-amino-acid metabolism
  • Disorders of gamma-glutamyl cycle

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code E72.89 are found in the index:


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • 2-hydroxyglutaric aciduria
  • 3-Phosphoglycerate dehydrogenase deficiency
  • 3-phosphoglycerate dehydrogenase deficiency infantile form
  • 3-phosphoglycerate dehydrogenase deficiency juvenile form
  • 5-Oxoprolinase deficiency
  • Alaninemia
  • Alpha ketoadipic aciduria
  • Aminoacidemia
  • Aminoaciduria
  • Aminoaciduria
  • Aminoaciduria
  • Aminoaciduria
  • Benign neonatal hyperaminoaciduria
  • Camptodactyly taurinuria syndrome
  • Combined D-2-hydroxyglutaric aciduria and L-2-hydroxyglutaric aciduria
  • Deficiency of 3-hydroxyisobutyrate dehydrogenase
  • Deficiency of 4-hydroxy-2-oxoglutarate aldolase
  • Deficiency of A-ase
  • Deficiency of acid-aminoacid ligase
  • Deficiency of adenosylhomocysteinase
  • Deficiency of alanine aminotransferase
  • Deficiency of alanine dehydrogenase
  • Deficiency of alanine-oxo-acid aminotransferase
  • Deficiency of alanine-tRNA ligase
  • Deficiency of aminoacylase 1
  • Deficiency of aminoacyl-histidine dipeptidase
  • Deficiency of aminoacyltransferase
  • Deficiency of aminopeptidase
  • Deficiency of aminotransferase
  • Deficiency of ammonia-lyase
  • Deficiency of asparagine-oxo-acid aminotransferase
  • Deficiency of aspartate 4-decarboxylase
  • Deficiency of aspartate aminotransferase
  • Deficiency of aspartate kinase
  • Deficiency of betaine-aldehyde dehydrogenase
  • Deficiency of betaine-homocysteine methyltransferase
  • Deficiency of carboxy-lyase
  • Deficiency of carboxypeptidase A
  • Deficiency of carboxypeptidase B
  • Deficiency of carnosinase
  • Deficiency of choline dehydrogenase
  • Deficiency of cysteamine dioxygenase
  • Deficiency of cysteine aminotransferase
  • Deficiency of cysteine carboxypeptidase
  • Deficiency of cysteine proteinase
  • Deficiency of cysteinyl-glycine dipeptidase
  • Deficiency of cystine reductase
  • Deficiency of cytosol aminopeptidase
  • Deficiency of D-amino-acid oxidase
  • Deficiency of D-aspartate oxidase
  • Deficiency of glutamate decarboxylase
  • Deficiency of glutamate dehydrogenase
  • Deficiency of glutamate-ammonia ligase
  • Deficiency of glutaminase
  • Deficiency of glutamine phenylacetyltransferase
  • Deficiency of glutamine-fructose-6-phosphate aminotransferase
  • Deficiency of glutamine-pyruvate aminotransferase
  • Deficiency of glutathione synthase
  • Deficiency of glycine amidinotransferase
  • Deficiency of glycine hydroxymethyltransferase
  • Deficiency of guanidinoacetate kinase
  • Deficiency of guanidinoacetate methyltransferase
  • Deficiency of homoserine kinase
  • Deficiency of L-amino-acid oxidase
  • Deficiency of L-asparagine amidohydrolase
  • Deficiency of L-serine ammonia-lyase
  • Deficiency of malonate CoA-transferase
  • Deficiency of N-methyl-L-amino-acid oxidase
  • Deficiency of phosphoserine phosphatase
  • Deficiency of proline dipeptidase
  • Deficiency of pyrroline-5-carboxylate reductase
  • Deficiency of serine carboxypeptidase
  • Deficiency of serine-tRNA ligase
  • Deficiency of threonine aldolase
  • Deficiency of threonine dehydratase
  • Deficiency of threonine-tRNA ligase
  • Dibasic aminoaciduria
  • Dicarboxylic aminoaciduria syndrome
  • Disorder of beta alanine, carnosine AND/OR homocarnosine metabolism
  • Disorder of beta and omega amino acid metabolism
  • Disorder of creatine synthesis
  • Disorder of glutamine metabolism
  • Disorder of phenylalanine metabolism
  • Disorder of proline AND/OR hydroxyproline metabolism
  • Disorder of serine metabolism
  • Disorder of tetrahydrobiopterin metabolism
  • Disorder of the gamma-glutamyl cycle
  • Disorder of threonine metabolism
  • gamma-Glutamyltransferase deficiency
  • Glucoaminophosphaturia syndrome
  • Glucoaminophosphaturia syndrome with rickets
  • Glutamate-cysteine ligase deficiency
  • Glutathione synthase deficiency with 5-oxoprolinuria
  • Glutathione synthase deficiency without 5-oxoprolinuria
  • Glutathionemia
  • Glycoprolinuria
  • Hereditary camptodactyly
  • Homocarnosinase deficiency
  • Hyper-beta-alaninemia
  • Hyper-beta-carnosinemia
  • Hyperdicarboxylicaminoaciduria AND hyperprolinemia
  • Hyperhydroxyprolinemia
  • Hyperprolinemia
  • Iminoacidopathy
  • Inborn error of amino acid metabolism
  • Inborn error of glutathione metabolism
  • Inherited aminoaciduria
  • Inherited aminoaciduria
  • Inherited aminoaciduria
  • Inherited aminoaciduria
  • Lysinuric protein intolerance
  • Phosphoserine aminotransferase deficiency
  • Pipecolic acidemia
  • Prolinuria
  • Succinate-semialdehyde dehydrogenase deficiency

Replacement Code

E7289 replaces the following previously assigned ICD-10 code(s):

  • E72.8 - Other specified disorders of amino-acid metabolism

Code Classification

  • Endocrine, nutritional and metabolic diseases (E00–E90)
    • Metabolic disorders (E70-E88)
      • Other disorders of amino-acid metabolism (E72)

Code History

  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients

Amino Acid Metabolism Disorders

Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Your digestive system breaks the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body. If you have a metabolic disorder, something goes wrong with this process.

One group of these disorders is amino acid metabolism disorders. They include phenylketonuria (PKU) and maple syrup urine disease. Amino acids are "building blocks" that join together to form proteins. If you have one of these disorders, your body may have trouble breaking down certain amino acids. Or there may be a problem getting the amino acids into your cells. These problems cause a buildup of harmful substances in your body. That can lead to serious, sometimes life-threatening, health problems.

These disorders are usually inherited. A baby who is born with one may not have any symptoms right away. Because the disorders can be so serious, early diagnosis and treatment are critical. Newborn babies get screened for many of them, using blood tests.

Treatments may include special diets, medicines, and supplements. Some babies may also need additional treatments if there are complications.

[Learn More]