ICD-10-CM Code E84.8

Cystic fibrosis with other manifestations

Version 2021 Billable Code

Valid for Submission

E84.8 is a billable code used to specify a medical diagnosis of cystic fibrosis with other manifestations. The code is valid for the fiscal year 2021 for the submission of HIPAA-covered transactions. The ICD-10-CM code E84.8 might also be used to specify conditions or terms like arthropathy associated with cystic fibrosis, azoospermia, azoospermia with absent vasa in association with cystic fibrosis trait, congenital obstructive azoospermia, cystic fibrosis of pancreas, cystic fibrosis transmembrane conductance regulator related metabolic syndrome, etc

Short Description:Cystic fibrosis with other manifestations
Long Description:Cystic fibrosis with other manifestations

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code E84.8 are found in the index:


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Arthropathy associated with cystic fibrosis
  • Azoospermia
  • Azoospermia with absent vasa in association with cystic fibrosis trait
  • Congenital obstructive azoospermia
  • Cystic fibrosis of pancreas
  • Cystic fibrosis transmembrane conductance regulator related metabolic syndrome
  • Cystic fibrosis with gastritis and megaloblastic anemia syndrome
  • Elevated liver enzymes level
  • Elevated liver enzymes level due to cystic fibrosis
  • Exocrine pancreatic manifestation co-occurrent and due to cystic fibrosis
  • Female infertility due to cystic fibrosis
  • Gastritis caused by bacterium
  • Helicobacter pylori-associated gastritis
  • Helicobacter-associated gastritis
  • Liver disease due to cystic fibrosis
  • Liver enzyme levels - finding
  • Liver enzymes abnormal
  • Male infertility due to cystic fibrosis
  • Male infertility of genetic origin
  • Osteoporosis due to cystic fibrosis
  • Otorhinolaryngological manifestation co-occurrent and due to cystic fibrosis
  • Pancreatic insufficiency
  • Pancreatic insufficiency due to cystic fibrosis of pancreas
  • Perinatal jaundice due to cystic fibrosis
  • Polyneuropathy due to classical cystic fibrosis
  • Portal hypertension
  • Portal hypertension due to cystic fibrosis

Diagnostic Related Groups

The ICD-10 code E84.8 is grouped in the following groups for version MS-DRG V38.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2020 through 09/30/2021.


Convert E84.8 to ICD-9

Code Classification

  • Endocrine, nutritional and metabolic diseases (E00–E90)
    • Metabolic disorders (E70-E88)
      • Cystic fibrosis (E84)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients

Cystic Fibrosis

Also called: CF

Cystic fibrosis (CF) is an inherited disease of the mucus and sweat glands. It affects mostly your lungs, pancreas, liver, intestines, sinuses, and sex organs. CF causes your mucus to be thick and sticky. The mucus clogs the lungs, causing breathing problems and making it easy for bacteria to grow. This can lead to repeated lung infections and lung damage.

The symptoms and severity of CF can vary. Some people have serious problems from birth. Others have a milder version of the disease that doesn't show up until they are teens or young adults. Sometimes you will have few symptoms, but later you may have more symptoms.

CF is diagnosed through various tests, such as gene, blood, and sweat tests. There is no cure for CF, but treatments have improved greatly in recent years. In the past, most deaths from CF were in children and teenagers. Today, with improved treatments, some people who have CF are living into their forties, fifties, or older. Treatments may include chest physical therapy, nutritional and respiratory therapies, medicines, and exercise.

NIH: National Heart, Lung, and Blood Institute

  • Cystic fibrosis (Medical Encyclopedia)
  • Cystic fibrosis - nutritional considerations (Medical Encyclopedia)
  • How to breathe when you are short of breath (Medical Encyclopedia)
  • Neonatal cystic fibrosis screening (Medical Encyclopedia)
  • Postural drainage (Medical Encyclopedia)
  • Sweat electrolytes test (Medical Encyclopedia)

[Learn More]

Cystic fibrosis Cystic fibrosis is an inherited disease characterized by the buildup of thick, sticky mucus that can damage many of the body's organs. The disorder's most common signs and symptoms include progressive damage to the respiratory system and chronic digestive system problems. The features of the disorder and their severity varies among affected individuals.Mucus is a slippery substance that lubricates and protects the linings of the airways, digestive system, reproductive system, and other organs and tissues. In people with cystic fibrosis, the body produces mucus that is abnormally thick and sticky. This abnormal mucus can clog the airways, leading to severe problems with breathing and bacterial infections in the lungs. These infections cause chronic coughing, wheezing, and inflammation. Over time, mucus buildup and infections result in permanent lung damage, including the formation of scar tissue (fibrosis) and cysts in the lungs.Most people with cystic fibrosis also have digestive problems. Some affected babies have meconium ileus, a blockage of the intestine that occurs shortly after birth. Other digestive problems result from a buildup of thick, sticky mucus in the pancreas. The pancreas is an organ that produces insulin (a hormone that helps control blood sugar levels). It also makes enzymes that help digest food. In people with cystic fibrosis, mucus often damages the pancreas, impairing its ability to produce insulin and digestive enzymes. Problems with digestion can lead to diarrhea, malnutrition, poor growth, and weight loss. In adolescence or adulthood, a shortage of insulin can cause a form of diabetes known as cystic fibrosis-related diabetes mellitus (CFRDM).Cystic fibrosis used to be considered a fatal disease of childhood. With improved treatments and better ways to manage the disease, many people with cystic fibrosis now live well into adulthood. Adults with cystic fibrosis experience health problems affecting the respiratory, digestive, and reproductive systems. Most men with cystic fibrosis have congenital bilateral absence of the vas deferens (CBAVD), a condition in which the tubes that carry sperm (the vas deferens) are blocked by mucus and do not develop properly. Men with CBAVD are unable to father children (infertile) unless they undergo fertility treatment. Women with cystic fibrosis may experience complications in pregnancy.
[Learn More]