Version 2024

2024 ICD-10-CM Diagnosis Code E75.26

Sulfatase deficiency

ICD-10-CM Code:: E75.26
ICD-10 Code for:: Sulfatase deficiency
Is Billable?: Yes - Valid for Submission
Chronic Condition Indicator: ^[1]: Chronic
Code Navigator:

Code Information
Approximate Synonyms
Clinical Classification
Clinical Information
Tabular List of Diseases and Injuries
Index to Diseases and Injuries References
Replacement Code
Patient Education
Other Codes Used Similar Conditions
Code History

Code Classification

Endocrine, nutritional and metabolic diseases
(E00–E89)
- Metabolic disorders
  (E70-E88)
  - Disorders of sphingolipid metabolism and other lipid storage disorders
    (E75)

E75.26 is a billable diagnosis code used to specify a medical diagnosis of sulfatase deficiency. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

Deficiency of sulfatase

Clinical Classification

Clinical Category	CCSR Category Code	Inpatient Default CCSR	Outpatient Default CCSR
Other nervous system disorders (often hereditary or degenerative)	NVS006	N - Not default inpatient assignment for principal diagnosis or first-listed diagnosis.	N - Not default outpatient assignment for principal diagnosis or first-listed diagnosis.
Other specified and unspecified nutritional and metabolic disorders	END016	Y - Yes, default inpatient assignment for principal diagnosis or first-listed diagnosis.	Y - Yes, default outpatient assignment for principal diagnosis or first-listed diagnosis.

Clinical Information

Other Sphingolipidosis|Other sphingolipidosis
evidence of other sphingolipidosis not specified elsewhere.
Sphingolipidosis
an inherited metabolic disorder that affects the metabolism of the spinhgolipids. representative examples include gaucher disease, tay-sachs disease, and niemann-pick disease.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.

Inclusion Terms

Multiple sulfatase deficiency (MSD)

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

- Deficiency, deficient
- - multiple sulfatase (MSD) - E75.26
- - sulfatase - E75.26

- MSD (multiple sulfatase deficiency) - E75.26

Replacement Code

E7526 replaces the following previously assigned ICD-10-CM code(s):

E75.29 - Other sphingolipidosis

Patient Education

Genetic Brain Disorders

A genetic brain disorder is caused by a variation or a mutation in a gene. A variation is a different form of a gene. A mutation is a change in a gene. Genetic brain disorders affect the development and function of the brain.

Some genetic brain disorders are due to random gene mutations or mutations caused by environmental exposure, such as cigarette smoke. Other disorders are inherited, which means that a mutated gene or group of genes is passed down through a family. They can also be due to a combination of both genetic changes and other outside factors.

Some examples of genetic brain disorders include:

Leukodystrophies
Phenylketonuria
Tay-Sachs disease
Wilson disease

Many people with genetic brain disorders fail to produce enough of certain proteins that influence brain development and function. These brain disorders can cause serious problems that affect the nervous system. Some have treatments to control symptoms. Some are life-threatening.

[Learn More in MedlinePlus]

Lipid Metabolism Disorders

Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system (enzymes) break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues. If you have a metabolic disorder, something goes wrong with this process.

Lipid metabolism disorders, such as Gaucher disease and Tay-Sachs disease, involve lipids. Lipids are fats or fat-like substances. They include oils, fatty acids, waxes, and cholesterol. If you have one of these disorders, you may not have enough enzymes to break down lipids. Or the enzymes may not work properly and your body can't convert the fats into energy. They cause a harmful amount of lipids to build up in your body. Over time, that can damage your cells and tissues, especially in the brain, peripheral nervous system, liver, spleen, and bone marrow. Many of these disorders can be very serious, or sometimes even fatal.

These disorders are inherited. Newborn babies get screened for some of them, using blood tests. If there is a family history of one of these disorders, parents can get genetic testing to see whether they carry the gene. Other genetic tests can tell whether the fetus has the disorder or carries the gene for the disorder.

Enzyme replacement therapies can help with a few of these disorders. For others, there is no treatment. Medicines, blood transfusions, and other procedures may help with complications.