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  6. 2026 ICD-10-CM Code E83.821

2026 ICD-10-CM Diagnosis Code E83.821

ENPP1 deficiency causing generalized arterial calcification of infancy

ICD-10-CM Code:
E83.821
ICD-10 Code for:
ENPP1 deficiency causing gen arterial calcifcn of infancy
Is Billable?
Yes - Valid for Submission
Code Navigator:

E83.821 is a billable diagnosis code used to specify a medical diagnosis of enpp1 deficiency causing generalized arterial calcification of infancy. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2025 through September 30, 2026.

Code Classification

  • Endocrine, nutritional and metabolic diseases
    E00–E89
    • Metabolic disorders
      E70-E88
      • Disorders of mineral metabolism
        E83

New 2026 ICD-10-CM Code

E83.821 is new to ICD-10-CM code set for the FY 2026, effective October 1, 2025. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2025. This is a new and revised code for the FY 2026 (October 1, 2025 - September 30, 2026).

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Code Also

Code Also
A "code also" note instructs that two codes may be required to fully describe a condition, but this note does not provide sequencing direction.
  • , if applicable, associated conditions such as:
  • heart failure I50
  • other secondary hypertension I15.8

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Index of External Cause of Injuries

References found for this diagnosis code in the External Cause of Injuries Index:

    • Calcification
      • arterial
        • generalized, of infancy
          • with
            • ENPP1 deficiency
    • Deficiency, deficient
      • ENPP1
        • causing
          • generalized arterial calcification of infancy

Replacement Code

E83821 replaces the following previously assigned ICD-10-CM code(s):

  • E83.89 - Other disorders of mineral metabolism

Code History

  • FY 2026 - Code Added, effective from 10/1/2025 through 9/30/2026