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  6. 2026 ICD-10-CM Code E78.019

2026 ICD-10-CM Diagnosis Code E78.019

Familial hypercholesterolemia, unspecified

ICD-10-CM Code:
E78.019
ICD-10 Code for:
Familial hypercholesterolemia, unspecified
Is Billable?
Yes - Valid for Submission
Code Navigator:

E78.019 is a billable diagnosis code used to specify a medical diagnosis of familial hypercholesterolemia, unspecified. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2025 through September 30, 2026.

Unspecified diagnosis codes like E78.019 are acceptable when clinical information is unknown or not available about a particular condition. Although a more specific code is preferable, unspecified codes should be used when such codes most accurately reflect what is known about a patient's condition. Specific diagnosis codes should not be used if not supported by the patient's medical record.

Code Classification

  • Endocrine, nutritional and metabolic diseases
    E00–E89
    • Metabolic disorders
      E70-E88
      • Disorders of lipoprotein metabolism and other lipidemias
        E78

Approximate Synonyms

The following list of clinical terms are approximate synonyms, alternative descriptions, or common phrases that might be used by patients, healthcare providers, or medical coders to describe the same condition. These synonyms and related diagnosis terms are often used when searching for an ICD-10 code, especially when the exact medical terminology is unclear. Whether you're looking for lay terms, similar diagnosis names, or common language alternatives, this list can help guide you to the correct ICD-10 classification.

  • Familial defective apolipoprotein B-100
  • Familial hyperalphalipoproteinemia
  • Familial hypercholesterolemia
  • Familial hypercholesterolemia due to genetic defect of apolipoprotein B
  • Hyperalphalipoproteinemia
  • Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency
  • Synthetic defect of bile acids

New 2026 ICD-10-CM Code

E78.019 is new to ICD-10-CM code set for the FY 2026, effective October 1, 2025. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2025. This is a new and revised code for the FY 2026 (October 1, 2025 - September 30, 2026).

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Familial hypercholesterolemia NOS

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Index of External Cause of Injuries

References found for this diagnosis code in the External Cause of Injuries Index:

    • Cholesterolemia(essential) (pure)
      • familial
    • Cholesterolemia(essential) (pure)
      • hereditary
    • Hypercholesterolemia(essential) (primary) (pure)
      • familial
    • Hypercholesterolemia(essential) (primary) (pure)
      • hereditary

Replacement Code

E78019 replaces the following previously assigned ICD-10-CM code(s):

  • E78.01 - Familial hypercholesterolemia

Code History

  • FY 2026 - Code Added, effective from 10/1/2025 through 9/30/2026