2027 ICD-10-CM Diagnosis Code E80Disorders of porphyrin and bilirubin metabolism

ICD-10-CM Codes›E00–E89›E70-E88›E80

ICD-10-CM E80
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E80 is a non-billable ICD-10-CM category code for disorders of porphyrin and bilirubin metabolism, so it cannot be submitted on claims. Use a more specific code from this category instead, such as E80.0, E80.1, E80.20, and E80.21.

Code Identity

ICD-10-CM Code
E80
Billable Status
No — Non-Billable Category
Code Describes
Disorders of porphyrin and bilirubin metabolism
Short Description
Disorders of porphyrin and bilirubin metabolism
Same as the full description in the CMS dataset.
Chapter
E70-E88
Metabolic disorders

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE80Disorders of porphyrin and bilirubin metabolism
This CodeE80Disorders of porphyrin and bilirubin metabolism

Specific Coding for Disorders of porphyrin and bilirubin metabolismOverview

Non-specific codes like E80 require more characters. Use one of these billable codes instead:

  • Use E80.0 for Hereditary erythropoietic porphyria

  • Use E80.1 for Porphyria cutanea tarda

  • E80.2 for Other and unspecified porphyria

  • Use E80.20 for Unspecified porphyria

  • Use E80.21 for Acute intermittent (hepatic) porphyria

  • Use E80.29 for Other porphyria

  • Use E80.3 for Defects of catalase and peroxidase

  • Use E80.4 for Gilbert syndrome

  • Use E80.5 for Crigler-Najjar syndrome

  • Use E80.6 for Other disorders of bilirubin metabolism

  • Use E80.7 for Disorder of bilirubin metabolism, unspecified

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E80: its own notes plus those printed at block E70-E88 and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

  • defects of catalase and peroxidase

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Block E70-E88 Metabolic disorders applies to 286 codes
  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block E70-E88 Metabolic disorders applies to 286 codes
  • Ehlers-Danlos syndromes (Q79.6-)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Patient EducationClinical

Metabolic Disorders

Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E80Overview

What is the ICD-10 code for disorders of porphyrin and bilirubin metabolism?

E80 is the ICD-10-CM category for disorders of porphyrin and bilirubin metabolism, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is E80 (Disorders of porphyrin and bilirubin metabolism) a billable code?

No. This is a category header that groups the codes for disorders of porphyrin and bilirubin metabolism, and headers cannot be submitted on claims. Claims for disorders of porphyrin and bilirubin metabolism need a more specific code from this category, such as E80.0, E80.1, and E80.20.

Can E80 be reported with a code from E34.5?

Not as a rule. The Excludes1 note at block E70-E88, which applies to E80, lists "androgen insensitivity syndrome (E34.5-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).