2024 ICD-10-CM Diagnosis Code E88.818

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

• Childhood obesity
• Diabetes mellitus due to genetic defect in insulin action
• Extreme insulin resistance with acanthosis nigricans, hirsutism AND autoantibodies to the insulin receptors
• Genetic non-syndromic obesity
• Glucose-galactose malabsorption
• Hirsutism
• Insulin resistance
• Insulin resistance - type B
• Malabsorption of glucose
• Severe early-onset obesity insulin resistance syndrome due to SH2B1 deficiency
• Severe obesity

Clinical Information

• Insulin Resistance

  diminished effectiveness of insulin in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

• Metabolic Syndrome

  a cluster of symptoms that are risk factors for cardiovascular diseases and type 2 diabetes mellitus. the major components of metabolic syndrome include abdominal obesity; atherogenic dyslipidemia; hypertension; hyperglycemia; insulin resistance; a proinflammatory state; and a prothrombotic (thrombosis) state.

• Hirsutism

  a condition observed in women and children when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. it is the result of elevated androgens from the ovaries, the adrenal glands, or exogenous sources. the concept does not include hypertrichosis, which is an androgen-independent excessive hair growth.

• Homeostatic Model Assessment of Insulin Resistance

  an assessment of beta-cell function and insulin resistance based on fasting blood glucose and insulin concentrations.

• Hyperandrogenism, Insulin Resistance, Acanthosis Nigricans Syndrome|HAIR-AN Syndrome

  a condition characterized by hyperandrogenism, insulin resistance, and acanthosis nigricans, typically associated with obesity in teenage girls. it is considered to be a subtype of polycystic ovarian syndrome, but may occur in male individuals. etiology is unclear, but some cases may be associated with mutations affecting the tyrosine kinase domain of the insulin receptor.

• Insulin Receptor Mutation - Associated Insulin Resistance Syndromes

  insulin resistance caused by inactivating mutation(s) in the insr gene encoding the insulin receptor.

• Insulin Resistance

  decreased sensitivity to circulating insulin which may result in acanthosis nigicrans, elevated insulin level or hyperglycemia.

• Insulin Resistance Measurement|INSULINR|Insulin Resistance|Insulin Resistance

  the determination of the insulin resistance (cells inability to respond to insulin) in a biological specimen.

• Insulin Resistance Syndrome

  a cluster of closely related metabolic abnormalities associated with insulin resistance that confer an increased risk of the development of type 2 diabetes and cardiovascular disease. these abnormalities may include obesity, high blood pressure, abnormal cholesterol levels, proteinuria, and/or polycystic ovary syndrome.

• Insulin Resistant Diabetes Mellitus with Acanthosis Nigricans and Hyperandrogenism|Type A Insulin Resistance Syndrome

  a syndrome of insulin resistance caused by mutation(s) in the insr gene, encoding the insulin receptor. this condition is characterized by a clinical triad of hyperinsulinemia, acanthosis nigricans, and hyperandrogenism without lipodystrophy. this is the least severe of a spectrum of disorders; the other two conditions are rabson-mendenhall syndrome and donohoe syndrome.

• Obesity-Associated Insulin Resistance

  insulin resistance associated with obesity, which may be attributed in part to impaired insulin signaling in target tissues, or impaired insulin-stimulated glucose transport due to reduced expression of the glucose transporter protein 4.

• Grade 1 Hirsutism, CTCAE|Grade 1 Hirsutism

  in women, increase in length, thickness or density of hair in a male distribution that the patient is able to camouflage by periodic shaving, bleaching, or removal of hair

• Grade 2 Hirsutism, CTCAE|Grade 2 Hirsutism

  in women, increase in length, thickness or density of hair in a male distribution that requires daily shaving or consistent destructive means of hair removal to camouflage; associated with psychosocial impact

• Hirsutism

  male-pattern hair growth on a female.

• Hirsutism, CTCAE|Hirsutism|Hirsutism

  a disorder characterized by the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen).

New 2024 ICD-10-CM Code

E88.818 is new to ICD-10-CM code set for the FY 2024, effective October 1, 2023. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2023. This is a new and revised code for the FY 2024 (October 1, 2023 - September 30, 2024).

Replacement Code

E88818 replaces the following previously assigned ICD-10-CM code(s):

• E88.81 - Metabolic syndrome
• E88.81 - Metabolic syndrome and other insulin resistance

Code History

• FY 2024 - Code Added, effective from 10/1/2023 through 9/30/2024